Yttrium and lanthanides in human lung fluids, probing the exposure to atmospheric fallout

Censi, P.; Tamburo, E.; Speziale, S.; Zuddas, Paola; Randazzo, Loredana; Punturo, Rosalda; Cuttitta, Angela; Arico, Pietro

doi:10.1016/j.jhazmat.2010.11.113

Cited by 53 publications

(21 citation statements)

References 48 publications

(59 reference statements)

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“…Regarding amphiboles, LREE which have ionic radii larger than HREE preferentially occupy the M(4) site while HREE are preferentially closer to the strip of octahedra at the M(4ʹ) site (Bottazzi et al, 1999). If these trace elements are released in the lungs, following the dissolution of fibres, they may bind to the phosphate (PO 4 3À ) groups, causing the development of harmful branching bony spicules in the lung parenchyma (Censi et al, 2011). Finally, many studies suggest that most of REE (La, Ce and Gd) possess the ability to generate reactive oxygen species (ROS) (Pagano et al, 2015a(Pagano et al, , 2015b; hence, with respect to this parameter, fibrous erionite may show a higher toxic potential.…”

Section: Rare Earth Elements (Ree)mentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

“…rare earth elements, REE) apparently non-carcinogenic in their simple ionic state, became carcinogenic when combined with certain macromolecular complexes (Censi et al, 2011). For example, the phosphate group (PO 4 3À ), present in the lungs can bond with lanthanides and crystallize in interstitial lung spaces, causing the development of harmful, branching bony spicules in the lung parenchyma (Censi et al, 2011). Moreover, REE-associated health effects have been associated with redox reactivity (Pagano et al, 2015a(Pagano et al, , 2015b, involving ROS formation, analogous to the recognized redox mechanisms observed in other transition elements such as iron and nickel.…”

Section: Introductionmentioning

confidence: 99%

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Trace elements in hazardous mineral fibres

Bloise

Barca

Gualtieri

et al. 2016

Environmental Pollution

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Both occupational and environmental exposure to asbestos-mineral fibres can be associated with lung diseases. The pathogenic effects are related to the dimension, biopersistence and chemical composition of the fibres. In addition to the major mineral elements, mineral fibres contain trace elements and their content may play a role in fibre toxicity. To shed light on the role of trace elements in asbestos carcinogenesis, knowledge on their concentration in asbestos-mineral fibres is mandatory. It is possible that trace elements play a synergetic factor in the pathogenesis of diseases caused by the inhalation of mineral fibres. In this paper, the concentration levels of trace elements from three chrysotile samples, four amphibole asbestos samples (UICC amosite, UICC anthophyllite, UICC crocidolite and tremolite) and fibrous erionite from Jersey, Nevada (USA) were determined using inductively coupled plasma mass spectrometry (ICP-MS). For all samples, the following trace elements were measured: Li, Be, Sc, V, Cr, Mn, Co, Ni, Cu, Zn, As, Rb, Sr, Y, Sb, Cs, Ba, La, Pb, Ce, Pr, Nd, Sm, Eu, Gd, Tb, Dy, Ho, Er, Tm, Yb, Lu, Th, U. Their distribution in the various mineral species is thoroughly discussed. The obtained results indicate that the amount of trace metals such as Mn, Cr, Co, Ni, Cu and Zn is higher in anthophyllite and chrysotile samples, whereas the amount of rare earth elements (REE) is higher in erionite and tremolite samples. The results of this work can be useful to the pathologists and biochemists who use asbestos minerals and fibrous erionite in-vitro studies as positive cyto- and geno-toxic standard references.

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Section: Rare Earth Elements (Ree)mentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Trace elements in hazardous mineral fibres

Bloise

Barca

Gualtieri

et al. 2016

Environmental Pollution

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“…In a recent study Censi and co-workers [4] demonstrated that inhalation of airborne particulate from Mount Etna eruptions may be responsible for fibrotic lung disease. The possible health effects experienced by construction workers excavating basaltic rock, which forms from volcanic eruptions, have never been investigated.…”

Section: Introductionmentioning

confidence: 99%

Professional exposure to basaltic rock dust: assessment by the Vibrio fischeri ecotoxicological test

Ledda

Rapisarda

Bracci³

et al. 2013

Journal of Occupational Medicine and Toxicology

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BackgroundA recent study demonstrates that inhalation of airborne particulate from Mount Etna eruptions may induce fibrotic lung disease. The occupational exposure of construction workers from the Etna area, who excavate building sites and use basalt dust to make mortar, has never been assessed.MethodsSamples of basalt, volcanic ash, basalt + cement and cement dust were collected on the construction site of a subway tunnel, ground to dust and subjected to the Microtox® solid-phase test to evaluate the toxicity of dust suspensions. Samples were investigated by scanning electron microscopy equipped with energy dispersive X-ray analysis (EDX). Minerals were identified and characterized by their morphology and elemental composition.ResultsThe elements found most frequently were C, Na, Mg, Al, Si, K, Ca, Ti, Mn, Fe and O. All four dusts were toxic: basalt and ash were significantly less toxic than basalt + cement and cement, which shared a similar and very high degree of toxicity. Higher Fe, Ca and Mg concentrations were associated with greater toxicity.ConclusionsThe risk related to long-term occupational exposure to various dusts on constructions sites in the Mount Etna area should be further assessed.

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“…They also showed that particle re-suspension is an issue post-deposition. Censi et al (2011a) proposed that yttrium-lanthanide phosphate precipitation can occur in human lungs following inhalation and dissolution of volcanic ash. Individuals exposed to the 2001 Etna ash had phosphatic microcrysts within their lungs, which can lead to pulmonary fibrosis, diagnosed by enrichments of yttrium and lanthanides (trace elements which have an affinity for phosphate) in broncho-alveolar lavage fluid.…”

Section: Summary Of Studies On the Respiratory Hazard Of Etnean Ashmentioning

confidence: 99%

The iron-catalysed surface reactivity and health-pertinent physical characteristics of explosive volcanic ash from Mt. Etna, Italy

et al. 2017

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Mount Etna is Europe's largest and most active volcano. In recent years, it has displayed enhanced explosive activity, causing concern amongst local inhabitants who frequently have to live with, and clean up, substantial ashfall. Basaltic volcanic ash is generally considered unlikely to be a respiratory health hazard due to its often coarse nature (with few particles sub-10 μm diameter) and lack of crystalline silica. However, a previous study by the authors showed the capability of basaltic ash to generate the hydroxyl radical, a highly-reactive species which may cause cell damage. That study investigated a single sample of Etna ash, amongst others, with data giving an early indication that the Etnean ash may be uniquely reactive. In this study, we analyse a suite of Etnean samples from recent and historical eruptions. Deposits indicate that Etna's past history was much more explosive than current activity, with frequent sub-plinian to plinian events. Given the recent increase in explosivity of Etna, the potential hazard of similarly, or more-explosive, eruptions should be assessed. A suite of physicochemical analyses were conducted which showed recent ash, from 2001 and 2002 explosive phases, to be of similar composition to the historical deposits (trachy-basaltic) but rather coarser (< 2.4 c.v.% sub-10 μm material and <11.5 c.v.% sub-10 μm material, respectively), but the potential for post-depositional fragmentation by wind and vehicles should not be ignored. One recent sample contained a moderate number of fibre-like particles, but all other samples were typical of fine-grained ash (blocky, angular with electrostatic or chemical aggregation of finer particles on larger ones). The surface reactivity analyses (Fenton chemistry, on samples from recent eruptions only) showed that Etnean ash is more reactive in hydroxyl radical generation than other basaltic ash, and samples of intermediate composition. This high reactivity suggests that Etnean ash could promote oxidative stress in exposed cells. Therefore, further investigation of the potential toxicity, through cellular tests, is now warranted in order to provide a comprehensive health hazard assessment.

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Yttrium and lanthanides in human lung fluids, probing the exposure to atmospheric fallout

Cited by 53 publications

References 48 publications

Trace elements in hazardous mineral fibres

Trace elements in hazardous mineral fibres

Professional exposure to basaltic rock dust: assessment by the Vibrio fischeri ecotoxicological test

The iron-catalysed surface reactivity and health-pertinent physical characteristics of explosive volcanic ash from Mt. Etna, Italy

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