Yttrium-90 radioembolisation versus transarterial chemoembolisation for unresectable hepatocellular carcinoma: a retrospective comparative analysis according to BCLC classification

Abstract

Objective: To present a case and literature review of gastric MANEC tumor locally invading into the duodenum and pancreas treated with pancreaticoduodenectomy. Methods: In this report we present a case of a 68 year old male who presents with a locally advanced gastric MANEC tumor with invasion into the duodenum and pancreas treated with pancreaticoduodenectomy. Results: The patient successfully underwent pancreaticoduodenectomy without complications and was discharged post-operative day 11. Pathology was consistent with gastric cancer with mixed adeno and neuroendocrine components. Conclusion: We describe a case of pathologically identified MANEC tumor of the stomach with local duodenal, pancreatic, and peripancreatic lymph node invasion treated with pancreaticoduodenectomy, which to our knowledge has not been described in the literature. Considerations can be made to evaluate MANEC pathology to further delineate the prognosis for patients undergoing R0 resection, due to the rare nature of this disease.

TACE versus TARE for patients with hepatocellular carcinoma: Overall and individual patient level meta analysis

“…Twelve of the included studies were retrospective cohort studies and the remainder consisted of one randomized trial and four prospective cohort studies. 10 , 14 , 15 , 16 , 18 , 19 , 20 , 21 , 22 , 23 , 24 , 25 , 26 , 27 , 28 , 29 , 30 The mean patient age was 62.1 years, and the majority were male (77.0%) and white (74.3%). Approximately two‐thirds of patients had compensated cirrhosis (Child Pugh [CP] A 65.4%) and the remainder were decompensated (CP B: 30.9%; CP C: 2.1%).…”

“…In total, our initial search revealed 1784 studies, 17 of which met inclusion criteria including 2465 unique patients (Figure S1). Twelve of the included studies were retrospective cohort studies and the remainder consisted of one randomized trial and four prospective cohort studies 10,14–16,18–30 . The mean patient age was 62.1 years, and the majority were male (77.0%) and white (74.3%).…”

“…Authors of all included studies were contacted for data sharing to include patient‐level data to allow IPD meta‐analysis, with the authors of three studies responding. These studies included papers by Moreno‐Luna et al, 14 Soydal et al, 15 and Massani et al 16 Prior to data transfer, we obtained University of Michigan and local site institutional review board approval, and deidentified data were transferred using data use agreements.…”