YTHDF2 protein stabilization by the deubiquitinase OTUB1 promotes prostate cancer cell proliferation via PRSS8 mRNA degradation

Zhao, Xuefeng; Lv, Suli; Li, Neng; Zou, Qingli; Sun, Lidong; Song, Tanjing

doi:10.1016/j.jbc.2024.107152

Journal of Biological Chemistry

2024

DOI: 10.1016/j.jbc.2024.107152

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YTHDF2 protein stabilization by the deubiquitinase OTUB1 promotes prostate cancer cell proliferation via PRSS8 mRNA degradation

Xuefeng Zhao,

Suli Lv,

Neng Li

et al.

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2024

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Cited by 2 publications

References 89 publications

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The YTH domain‐containing protein family: Emerging players in immunomodulation and tumour immunotherapy targets

Li,

Zeng,

Liu

et al. 2024

Clinical & Translational Med

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BackgroundThe modification of N6‐methyladenosine (m6A) plays a pivotal role in tumor by altering both innate and adaptive immune systems through various pathways, including the regulation of messenger RNA. The YTH domain protein family, acting as “readers” of m6A modifications, affects RNA splicing, stability, and immunogenicity, thereby playing essential roles in immune regulation and antitumor immunity. Despite their significance, the impact of the YTH domain protein family on tumor initiation and progression, as well as their involvement in tumor immune regulation and therapy, remains underexplored and lacks comprehensive review.ConclusionThis review introduces the molecular characteristics of the YTH domain protein family and their physiological and pathological roles in biological behavior, emphasizing their mechanisms in regulating immune responses and antitumor immunity. Additionally, the review discusses the roles of the YTH domain protein family in immune‐related diseases and tumor resistance, highlighting that abnormal expression or dysfunction of YTH proteins is closely linked to tumor resistance.Key points This review provides an in‐depth understanding of the YTH domain protein family in immune regulation and antitumor immunity, suggesting new strategies and directions for immunotherapy of related diseases. These insights not only deepen our comprehension of m6A modifications and YTH protein functions but also pave the way for future research and clinical applications.

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The YTH domain‐containing protein family: Emerging players in immunomodulation and tumour immunotherapy targets

Li,

Zeng,

Liu

et al. 2024

Clinical & Translational Med

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The m6A regulators in prostate cancer: molecular basis and clinical perspective

Cao,

Jia,

Duan

et al. 2024

Front. Pharmacol.

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Prostate cancer (PCa) is the second leading cause of cancer-related death among men in western countries. Evidence has indicated the significant role of the androgen receptor (AR) as the main driving factor in controlling the development of PCa, making androgen receptor inhibition (ARI) therapy a pivotal management approach. In addition, AR independent signaling pathways also contribute to PCa progression. One such signaling pathway that has garnered our attention is N6-Methyladenosine (m6A) signaling, which refers to a chemical modification on RNA with crucial roles in RNA metabolism and disease progression, including PCa. It is important to comprehensively summarize the role of each individual m6A regulator in PCa development and understand its interaction with AR signaling. This review aims to provide a thorough summary of the involvement of m6A regulators in PCa development, shedding light on their upstream and downstream signaling pathways. This summary sets the stage for a comprehensive review that would benefit the scientific community and clinical practice by enhancing our understanding of the biology of m6A regulators in the context of PCa.

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YTHDF2 protein stabilization by the deubiquitinase OTUB1 promotes prostate cancer cell proliferation via PRSS8 mRNA degradation

Cited by 2 publications

References 89 publications

The YTH domain‐containing protein family: Emerging players in immunomodulation and tumour immunotherapy targets

The YTH domain‐containing protein family: Emerging players in immunomodulation and tumour immunotherapy targets

The m6A regulators in prostate cancer: molecular basis and clinical perspective

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