YT521-B homology domain family proteins as N6-methyladenosine readers in tumors

Abstract

N6-methyladenosine (m6A) is the most abundant internal chemical modification of eukaryotic mRNA and plays diverse roles in gene regulation. The m6A modification plays a significant role in numerous cancer types, including kidney, stomach, lung, bladder tumors, and melanoma, through varied mechanisms. As direct m6A readers, the YT521-B homology domain family proteins (YTHDFs) play a key role in tumor transcription, translation, protein synthesis, tumor stemness, epithelial–mesenchymal transition (EMT), immune escape, and chemotherapy resistance. An in-depth understanding of the molecular mechanism of YTHDFs is expected to provide new strategies for tumor treatment. In this review, we provide a systematic description of YTHDF protein structure and its function in tumor progression.

YTHDF3 phase separation regulates HSPA13‐dependent clear cell renal cell carcinoma development and immune evasion

“…The GSEA results further showed that a high level of YTHDF3 was enriched in gene sets associated with the suppression of invasion and metastasis (Figure 2B,C), suggesting YTHDF3 correlated with the inhibition of ccRCC malignancy. Given that YTHDFs regulated tumor immunity and influenced tumor malignancy, 13,23,24 we also explored the relationship between YTHDF3 and tumor immune dysfunction.…”