YSK2821, a newly synthesized indoledione derivative, inhibits cell proliferation and cell cycle progression via the cell cycle-related proteins by regulating phosphatidylinositol-3 kinase cascade in vascular smooth muscle cells

Seo, Ji-Min; Kim, Tack-Joong; Jin, Yong-Ri; Han, Heon-Seok; Ryu, Chong Kul; Sheen, Yhun Yhong; Kim, Dong Ho; Yun, Young Won

doi:10.1016/j.ejphar.2008.02.076

Cited by 13 publications

(6 citation statements)

References 30 publications

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“…). Through the phosphorylation and inactivation of pro‐apoptotic proteins, AKT mediates cell survival and growth . Therefore, DMC likely inhibits the ERK1/2‐MAPK and other pro‐proliferative signaling pathways—likely the PI3K/AKT pathway—to regulate serum‐induced VSMC cell proliferation and migration.…”

Section: Discussionmentioning

confidence: 99%

Demethoxycurcumin, a major active curcuminoid from Curcuma longa, suppresses balloon injury induced vascular smooth muscle cell migration and neointima formation: An in vitro and in vivo study

Sheu

Lin

Yang

et al. 2013

Molecular Nutrition Food Res

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Section: Discussionmentioning

confidence: 99%

Demethoxycurcumin, a major active curcuminoid from Curcuma longa, suppresses balloon injury induced vascular smooth muscle cell migration and neointima formation: An in vitro and in vivo study

Sheu

Lin

Yang

et al. 2013

Molecular Nutrition Food Res

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“…PDGF-ββ binding to the PDGF receptor leads to the activation of several intracellular signaling cascades [29-31]. We next determined whether atorvastatin calcium affects the activation of PDGF-Rβ and its downstream signaling molecules, such as (PI3K)/Akt, (PLC)-γ1 and (ERK) 1/2 (Fig.…”

Section: Resultsmentioning

confidence: 99%

Atorvastatin Calcium Inhibits PDGF-ββ-Induced Proliferation and Migration of VSMCs Through the G0/G1 Cell Cycle Arrest and Suppression of Activated PDGFRβ-PI3K-Akt Signaling Cascade

Chen¹,

Dong²,

Zhao³

et al. 2017

Cell Physiol Biochem

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Background/Aims: Abnormal proliferation of vascular smooth muscle cells (VSMCs) is a hallmark of vascular lesions, such as atherosclerosis and restenosis. PDGF-ββ, an isoform of PDGF (platelet-derived growth factor), has been demonstrated to induce proliferation and migration of VSMCs. Atorvastatin calcium, a selective inhibitor of 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase, has favorable protective effects on VSMCs. This study examined the effects of atorvastatin calcium on the proliferation and migration of PDGF-ββ-treated VSMCs, as well as its underlying mechanisms. Methods: MTT assays, Edu imaging, cell cycle analysis, wound healing assays, transwell migration assays, and western blot analysis were performed. Results: Atorvastatin calcium significantly inhibited cell proliferation, DNA synthesis and cell migration of PDGF-ββ-treated VSMCs. We demonstrated that atorvastatin calcium induced cell cycle arrest in the G0/G1 phase in response to PDGF-ββ stimulation and decreased the expression of G0/G1-specific regulatory proteins, including proliferating cell nuclear antigen (PCNA), CDK2, cyclin D1, cyclin E and CDK4 in PDGF-ββ-treated VSMCs. Moreover, pretreatment with atorvastatin calcium inhibited the PDGF-ββ-treated phosphorylation of PDGFRβ and Akt, whereas atorvastatin calcium did not affect the phosphorylation of PLC-γ1 or (ERK) 1/2. Conclusion: Our data suggested that atorvastatin calcium inhibited abnormal proliferation and migration of VSMCs through G0/G1 cell cycle arrest and suppression of the PDGFRβ-Akt signaling cascade.

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“…Level of AKT kinase phosphorylation was increased by serum in our study and GLY inhibited serum-induced phosphorylation of AKT and PI3K, indicating that AKT protein is another potential target for GLY (Figure 4B). AKT mediates cell survival and growth signals by phosphorylating and inactivating pro-apoptotic proteins [34]. Therefore, these results indicate that the ERK1/2-MAPK pathway likely synergizes with other pro-proliferative signaling pathway(s), quite possibly the PI3K/AKT pathway, to regulate serum-induced VSMCs cell proliferation and migration.…”

Section: Discussionmentioning

confidence: 99%

A Chinese herbal formula "Gan-Lu-Yin" suppresses vascular smooth muscle cell migration by inhibiting matrix metalloproteinase-2/9 through the PI3K/AKT and ERK signaling pathways

Chien

Sheu

et al. 2012

BMC Complement Altern Med

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BackgroundThis study was to explore the effects of Gan-Lu-Yin (GLY) on the migration of vascular smooth muscle cells (VSMCs) induced by fetal bovine serum and on neointima formation in a rat model of carotid artery balloon injury.MethodsVSMCs were treated with different concentrations of GLY, and then analyzed with Flow cytometric analysis, zymography, transwell, and western blotting. SD rats received balloon-injury were analyzed with H&E staining.ResultsOur results showed that GLY significantly decreased the thickness of neointima. The inhibition by non-cytoxic doses of GLY of VSMCs migration was through its negative regulatory effects on phosphorylated ERK1/2, PI3K/AKT, and FAK. The data showed that GLY can inhibit the migration of VSMCs cells, and might block injury-induced neointima hyperplasia via the inhibition of VSMCs migration, without inducing apoptosis.ConclusionsThese observations provide a mechanism of GLY in attenuating cell migration, thus as a potential intervention for restenosis.

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YSK2821, a newly synthesized indoledione derivative, inhibits cell proliferation and cell cycle progression via the cell cycle-related proteins by regulating phosphatidylinositol-3 kinase cascade in vascular smooth muscle cells

Cited by 13 publications

References 30 publications

Demethoxycurcumin, a major active curcuminoid from Curcuma longa, suppresses balloon injury induced vascular smooth muscle cell migration and neointima formation: An in vitro and in vivo study

Demethoxycurcumin, a major active curcuminoid from Curcuma longa, suppresses balloon injury induced vascular smooth muscle cell migration and neointima formation: An in vitro and in vivo study

Atorvastatin Calcium Inhibits PDGF-ββ-Induced Proliferation and Migration of VSMCs Through the G0/G1 Cell Cycle Arrest and Suppression of Activated PDGFRβ-PI3K-Akt Signaling Cascade

A Chinese herbal formula "Gan-Lu-Yin" suppresses vascular smooth muscle cell migration by inhibiting matrix metalloproteinase-2/9 through the PI3K/AKT and ERK signaling pathways

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