Young's modulus measurements of soft tissues with application to elasticity imaging

Chen, E.J.; Novakofski, J.; Jenkins, W.K.; O’Brien, W.D.

doi:10.1109/58.484478

Cited by 268 publications

(159 citation statements)

References 12 publications

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“…US elastography is noninvasive and assesses tissue deformability by providing information on the elasticity [6,7]. It is based on the premise that there are significant differences in the mechanical properties of tissues that can be detected by applying an external mechanical force [8,9].…”

Section: Introductionmentioning

confidence: 99%

Breast elastography: A literature review

Goddi¹,

Bonardi

Alessi

2012

Journal of Ultrasound

134

129

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KEYWORDS Sonoelastography; Breast elastography; Breast lesions.Abstract Breast elastography is a new sonographic imaging technique which provides information on breast lesions in addition to conventional ultrasonography (US) and mammography. Elastography provides a noninvasive evaluation of the stiffness of a lesion. Today, two technical solutions are available for clinical use: strain elastography and shear wave elastography. Initial evaluations of these techniques in clinical trials suggest that they may substantially improve the possibility of differentiating benign from malignant breast lesions thereby limiting recourse to biopsy and considerably reducing the number of benign breast biopsy diagnoses. This article reviews the basics of this technique, how to perform the examination, image interpretation and the results of major clinical studies. Although elastography is easy to perform, training and technical knowledge are required in order to obtain images permitting a correct interpretation. This paper will highlight the technique and point out common pitfalls.Sommario L'elastosonografia mammaria è una nuova tecnica di imaging a ultrasuoni che fornisce informazioni aggiuntive sulle lesioni della mammella rispetto all'ecografia e alla mammografia. Consente una valutazione non invasiva della rigidità tessutale di una lesione. Sono attualmente disponibili due soluzioni tecniche per uso clinico: l'elastografia con strain e l'elastografia shear wave. I primi studi clinici di valutazione di queste tecniche suggeriscono che esse possano migliorare la caratterizzazione delle lesioni mammarie differenziando quelle benigne dalle maligne e riducendo in modo sostanziale il numero di biopsie per lesioni benigne. Questo articolo rivisita le basi tecniche, i criteri interpretativi delle immagini, i principali studi clinici e le possibili cause di errore. Per quanto l'elastosonografia sia di facile esecuzione, richiede tuttavia un training e delle conoscenze tecniche adeguate per ottenere immagini correttamente interpretabili. ª

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Section: Introductionmentioning

confidence: 99%

Breast elastography: A literature review

Goddi¹,

Bonardi

Alessi

2012

Journal of Ultrasound

134

129

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“…The sample is modeled as elastic, linear, isotropic and quasi-incompressible. Most soft tissues are assumed to have a Poisson's ratio between v=0.45 and v=0.49 (Chen et al 1996). Since thrombi may not be incompressible especially during the acute phase when serum or blood might be forced out of a thrombus during deformation, we modeled our tissue sample with a Poisson's ratio in a broader range of 0.40 < v < 0.49.…”

Section: Finite Element Simulationsmentioning

confidence: 99%

“…For tissue specimens that can be excised into large homogeneous pieces, for example, liver and muscle, the traditional approach is uniaxial compression (Chen et al 1996). For small tissue samples (breast and prostate), a majority of existing systems are indentation apparatus (Erkamp et al 1998;Krouskop et al 1998;Samani et al 2003).…”

Section: Introductionmentioning

confidence: 99%

Correspondence of ultrasound elasticity imaging to direct mechanical measurement in aging DVT in rats

Xie

Kim

Aglyamov

et al. 2005

Ultrasound in Medicine & Biology

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Previous ultrasound elasticity imaging experiments supported a generally accepted concept that the hardness of deep venous thrombi increases with thrombus aging. Results also showed that this noninvasive imaging technique can accurately predict thrombus age through strain estimates in a well controlled animal study. In the present study, as an alternative means to characterize elastic properties of thrombi, we employed a direct mechanical measurement system to estimate Young's modulus of ex vivo thrombi. Unlike conventional indentation tests, the device utilizes a specific compression geometry for cylindrical tissue specimens. We also proposed an approximation scheme to retrieve Young's modulus from force-displacement measurements made using the device. Finite element simulations and calibrations on tissue-mimicking phantoms validated the system. Then, using two groups of rats with surgically induced thrombi, we further investigated the correlation between Young's modulus measured ex vivo and elasticity images reconstructed in vivo. This comparison was accomplished by converting the intra-thrombus strains measured in the in vivo studies into Young's modulus estimates using a model based approach. Good agreement between time-dependent Young's modulus estimates observed in vivo and direct measurements of Young's modulus using the mechanical device helps to confirm the ability of elasticity imaging to age DVT for efficient treatment.

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“…By varying other parameters, such as the degree of substitution, molecular weight, or concentration of HA-furan, the shear moduli may be further manipulated to mimic those of connective tissue, liver, and the mammary fat pad, among others. For example, the shear elastic moduli of liver, fat, relaxed muscle, and breast gland tissue range from 1000 -10,000 Pa [80][81][82] . These values could be achieved by using a higher molecular weight HA or a higher HA weight concentration 79 .…”

mentioning

confidence: 99%

Diels−Alder Click Cross-Linked Hyaluronic Acid Hydrogels for Tissue Engineering

2011

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Hyaluronic acid (HA) is a naturally occurring polymer that holds considerable promise for tissue engineering applications. Current cross-linking chemistries often require a coupling agent, catalyst, or photoinitiator, which may be cytotoxic, or involve a multistep synthesis of functionalized-HA, increasing the complexity of the system. With the goal of designing a simpler one-step , aqueous-based cross-linking system, we synthesized HA hydrogels via Diels-Alder "click" chemistry. Furan-modified HA derivates were synthesized and cross-linked via dimaleimide poly(ethylene glycol). By controlling the furan to maleimide molar ratio, both the mechanical and degradation properties of the resulting Diels-Alder cross-linked hydrogels can be tuned. Rheological and degradation studies demonstrate that the Diels-Alder click reaction is a suitable cross-linking method for HA. These HA cross-linked hydrogels were shown to be cytocompatible and may represent a promising material for soft tissue engineering.iii

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Young's modulus measurements of soft tissues with application to elasticity imaging

Cited by 268 publications

References 12 publications

Breast elastography: A literature review

Breast elastography: A literature review

Correspondence of ultrasound elasticity imaging to direct mechanical measurement in aging DVT in rats

Diels−Alder Click Cross-Linked Hyaluronic Acid Hydrogels for Tissue Engineering

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