Young patients with risk factors prevalent in the elderly &amp;ndash;&amp;nbsp;&lt;br /&gt;differences in comorbidity depending on severity of psoriasis: a nationwide cross-sectional study in Swedish health registers

Hajiebrahimi, Mohammadhossein; Linder, Marie; Hägg, David; Berglind, Ina Anveden; McElligott, Sean; Valgardsson, Valgard Sverrir; Villacorta, R.; Sundström, Anders

doi:10.2147/clep.s164918

Cited by 10 publications

(17 citation statements)

References 35 publications

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“…Hajiebrahimi et al found the prevalence of hypertension in psoriasis patients at 29.9% (moderate psoriasis), 32.6% (moderate-severe psoriasis), and 36.5% (severe psoriasis). 4 The French study mentioned above found the prevalence to be 26%. 12 An Australas Journal of Dermatology paper reports the rate of hypertension in psoriasis patients to be 30%, 14 as does a Brazilian study.…”

Section: Hypertensionmentioning

confidence: 93%

“…14 According to Hajiebrahimi et al, metabolic syndrome has a prevalence of 50% in psoriasis patients. 4 Argote et al also found a high 50% prevalence. 13 A similarly high finding in a study of 97 patients, reports 49.4% prevalence.…”

Section: Metabolic Syndromementioning

confidence: 94%

“…According to a 2018 study on patients in Swedish health registries, the prevalence of DMII is 7.6% (mild psoriasis), 8.0% (moderate-severe psoriasis), and 10.7% (severe psoriasis). 4 French and Czech studies found the prevalence of DMII in psoriatic patients to be 11% 12 and 11.4% 8 respectively. The Czech study also refers to other European registries showing a prevalence of DMII in psoriasis patients of 9.9-12%.…”

Section: Type 2 Diabetes Mellitusmentioning

confidence: 97%

“…According to a 2018 study published by Hajiebrahimi et al, myocardial infarction had a prevalence of 2.5%, 2.3%, and 1.8%, when Psoriasis was mild, moderate, and severe, respectively. 4 It also suggested that younger patients were at higher risk of myocardial infarction. That range of results is supported by a 2015 study, which found that 2.59% of psoriasis patients had a major cardiovascular event as compared to 2.3% of controls.…”

Section: Cardiovascular Diseasementioning

confidence: 99%

“…One study, however, demonstrated a 2.4% prevalence of stroke in individuals with mild psoriasis, 2.2% in individuals with moderate to severe psoriasis, and 1.1% in individuals with severe psoriasis. 4…”

Section: Strokementioning

confidence: 99%

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Review of the Prevalence of Cardiovascular and Metabolic Comorbidities of Psoriasis

Vebman¹,

Choy²,

Yao³

2020

J of Skin

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Introduction:-Psoriasis is a common disease that is linked with several other diseases. Our goals were to analyze and present literature on prevalence of various psoriatic comorbidities, and provide an estimate of what percent of psoriasis patients might have or develop Myocardial/cardiovascular/heart disease, stroke, diabetes, obesity, hypertension, or metabolic syndrome.Method:-To collect the results, we searched PubMed to identify papers that studied the frequency of the most common comorbidities of psoriasis. We used about 20. The search terms used were the particular comorbidity (or synonyms) and psoriasis. Papers were selected where the prevalence data were listed by percentages of the studied population. Prevalence data from each paper were collected and charted, and then compared. We did not use data that concerned Psoriatic Arthritis. We also recorded outliers, where frequencies did not fit with the other data found.Results:-Results for prevalence of myocardial/cardiovascular/heart disease were mixed, varying by age and severity of disease. There are few papers on prevalence of stroke, but our review suggests risk of stroke increases with severity of psoriasis. The prevalence of diabetes was largely between 10% and 20%. Obesity’s prevalence was mostly between 15% and 30%, while hypertension hovered around 30%, and metabolic syndrome prevalence was mostly between 27% and 50%.Conclusions:-There are many comorbidities of psoriasis. The complex interaction between cutaneous inflammation and heart disease, stroke, diabetes, hypertension and metabolic syndrome raises many questions about cause and effect or simple association.

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Section: Hypertensionmentioning

confidence: 93%

Section: Metabolic Syndromementioning

confidence: 94%

Section: Type 2 Diabetes Mellitusmentioning

confidence: 97%

Section: Cardiovascular Diseasementioning

confidence: 99%

Section: Strokementioning

confidence: 99%

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Review of the Prevalence of Cardiovascular and Metabolic Comorbidities of Psoriasis

Vebman¹,

Choy²,

Yao³

2020

J of Skin

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Real-world study of direct medical and indirect costs and time spent in healthcare in patients with chronic graft versus host disease

Schain¹,

Batyrbekova

Liwing

et al. 2020

Eur J Health Econ

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Chronic graft versus host disease (cGVHD) is a debilitating and costly complication following haemopoietic stem cell transplantation (HSCT). This study describes the economic burden associated with cGVHD. Direct costs associated with specialised healthcare utilisation (inpatient admissions and outpatient visits), as well as indirect costs associated with sickness absence-associated productivity loss were estimated in patients who underwent allogeneic HSCT in Sweden between 2006 and 2015, linking population-based health and economic registers. To capture the period of chronic GVHD, patients were included who survived > 182 days post-HSCT (start of follow-up), and cGVHD was classified based on patient treatment records to correct for any diagnosis underreporting. Patients were classified as ‘non-cGVHD’ if they received no immunosuppressive treatment, ‘mild cGVHD’ if they received only systemic corticosteroid treatment or immunosuppressive treatment, or ‘moderate–severe cGVHD’ if they received extracorporeal photopheresis (ECP) only, corticosteroid treatment and immunosuppressive treatment, or systemic corticosteroid treatment and ECP treatments. Patients with moderate–severe cGVHD spent more time in healthcare, had higher healthcare resource costs and higher sickness absence-related productivity loss compared to patients with non- or mild cGVHD. The cumulative total costs during the first 3 years of follow-up were EUR 14,887,599, EUR 20,544,056, and EUR 47,811,835 for non-, mild, and moderate–severe groups, respectively. The long-term costs incurred with cGVHD following HSCT continue to be very high and significantly impacted by cGVHD severity. This study adds real-world health resource and economic insight relevant for policy-makers and healthcare providers when considering the clinical challenge of balancing immunosuppression to reduce cGVHD.

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Societal impact for patients with psoriasis: A nationwide Swedish register study

et al. 2021

Self Cite

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Background: Psoriasis is an immune-mediated chronic inflammatory disease having a significant negative health impact. Psoriasis has societal impact; loss of productivity has been estimated at approximately 10% and it may influence the patient's financial status. Relationships between quality of life, disease severity, and cost of care need exploration. Understanding the disease burden is important for health policy and research allocation. Few studies address the research gaps in socioeconomics, comorbidity, and medication use.Objective: Observing differences in education, income, employment status, marital status, health care consumption, and drug utilization between patients with psoriasis and matched controls.Methods: Cohort study following socioeconomics and health care consumption for all psoriasis patients from the Swedish patient register. All individuals with a first diagnosis of psoriasis in outpatient or inpatient care from 2002 to 2013 were followed until death, emigration, or end of the study.Results: Overall, 109,803 patients were included (mean age 51.2 years, 53% women) and matched with 1.08 million controls. The levels of education and income were similar, but the proportion employed was significantly lower for patients with psoriasis. There was a tendency for fewer patients with psoriasis to be married.Limitations: Generalizability, lack of primary care diagnoses, and lack of early treatments (available from 2005). Conclusion:Understanding of the socioeconomic impact of psoriasis is extended by showing reductions in employment. ( JAAD Int 2021;3:63-75.)

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Young patients with risk factors prevalent in the elderly – <br />differences in comorbidity depending on severity of psoriasis: a nationwide cross-sectional study in Swedish health registers

Cited by 10 publications

References 35 publications

Review of the Prevalence of Cardiovascular and Metabolic Comorbidities of Psoriasis

Review of the Prevalence of Cardiovascular and Metabolic Comorbidities of Psoriasis

Real-world study of direct medical and indirect costs and time spent in healthcare in patients with chronic graft versus host disease

Societal impact for patients with psoriasis: A nationwide Swedish register study

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