Young patients with hip fracture: a population-based study of bone mass and risk factors for osteoporosis

Lofthus, C. M.; Osnes, E.; Meyer, Haakon E; Kristiansen, Ivar Sønbø; Nordsletten, Lars; Falch, Jan A.

doi:10.1007/s00198-006-0176-0

Cited by 37 publications

(40 citation statements)

References 29 publications

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“…It is an important finding as most likely the majority of individuals with osteopenia will develop osteoporosis within the coming 10 years [24]. Similar results as ours have been reported earlier; however, the BMD examinations in these studies were performed at an average of 3-4 years after the hip fracture and not during the first weeks as in the present study [25,26]. It is well known that patients suffer a rapid and pronounced loss of BMD during the first months following a hip fracture [27,28].…”

Section: Discussionsupporting

confidence: 90%

Low bone mineral density and fat‐free mass in younger patients with a femoral neck fracture

Al-Ani

Cederholm

Sääf³

et al. 2015

Eur J Clin Investigation

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Section: Discussionsupporting

confidence: 90%

Low bone mineral density and fat‐free mass in younger patients with a femoral neck fracture

Al-Ani

Cederholm

Sääf³

et al. 2015

Eur J Clin Investigation

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“…In the animal model, femurs of diabetic rats were found to have lower energy absorption capacity and increased bending stiffness (27), which may have predisposed them to fracture with minimal trauma. Such low bone quality with increased frequency of falls in younger adult diabetic patients may have caused a higher risk of nontraumatic accident hip fracture, which is relatively rare in the general population aged Ͻ50 years (28). People with diabetes, especially younger adults, are a lot less physically active than people without diabetes, which in turn might lead to lower bone density.…”

Section: Results -The Meanmentioning

confidence: 99%

Increased Risks of Hip Fracture in Diabetic Patients of Taiwan

Chen

Ho²,

2008

Diabetes Care

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OBJECTIVE -Using Taiwan's National Health Insurance claim data, we evaluated the age-, sex-, and urbanization-specific incidence density and relative risks of hip fracture in the diabetic population.RESEARCH DESIGN AND METHODS -Diabetic patients (n ϭ 500,868) and an ageand sex-matched control group (n ϭ 500,248) were linked to inpatient claims (1997)(1998)(1999)(2000)(2001)(2002) to identify hospitalizations for nontransport accident hip fracture. The person-year approach with Poisson assumption and Kaplan-Meier analysis were used to estimate the incidence and the cumulative event rates. We also assessed the age-, sex-, and urbanization-specific relative risks of hip fracture in relation to diabetes with the Cox proportional hazard regression model. RESULTS-The overall incidences of hip fracture for diabetic men and women, respectively, were 3.01 and 6.75/1,000 person-years, which were higher than those for control men and women. There were significant interactions of diabetes and age and diabetes and urbanization statuses. Hazard ratios (HRs) of diabetic patients aged 35-44 years (men 2.45 [95% CI 1.65-3.64]; women 3.19 [1.39 -7.33]) were higher than those of diabetic patients aged 55-64 years (men 1.90; women 2.81), but in diabetic men aged Ͼ74 years and diabetic women aged Ͼ84 years, the HRs were compared with null statistically (HRs 0.98 and 0.91, respectively). Diabetic patients living in rural areas tended to have higher HRs of hip fracture.CONCLUSIONS -In Taiwan, diabetes increased the risk of hip fracture in both sexes in all age-groups except in diabetic men aged Ͼ74 years and diabetic women aged Ͼ84 years. Higher HRs of hip fracture were disproportionately observed in younger diabetic patients and in those living in rural areas. Diabetes Care 31:75-80, 2008T he incidence of hip fracture is expected to increase worldwide (1), and subsequent functional disability, morbidity, and mortality contribute tremendous health problems to our society. Diabetic patients, who have already been crippled by various microvascular and macrovascular complications, were reported to have increased risks of hip fracture (2-10). Much of the previous research, however, focused on women (4,5,8) or on older patients aged Ͼ65 years (4,9) so that relatively few data were available for specific risks in various agegroups and sex groups. Nearly all published studies were conducted in whites (10), and little information is available for Asian diabetic populations. Moreover, a recent study indicated that the relative risk of macrovascular disease associated with diabetes showed a significant geographic variation in Taiwan, implying a differential quality of care delivered to the diabetic patients in certain areas (11). No study so far has been conducted to investigate whether there is an urban-rural difference in incidence and relative risk of hip fracture in diabetic patients. In Taiwan, the high incidence (12) of hip fracture in the general population was reported previously, but the incidence of hip fracture among diabetic patient...

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“…This is the most common presentation of osteoporosis ( 1 ). In much of the literature studying osteoporosis or osteopenia, there is an attempt to classify the cause of the fracture(s) into low-energy (i.e., fall at the same level) or highenergy (fall from higher level or traumatic accident) trauma ( 12 ). Even though this fracture occurred under the novel medical situation of sustained 1 6 G z , it is safe to classify this occurrence as a low-energy fracture.…”

Section: Discussionmentioning

confidence: 99%

Vertebral Fracture in a Pilot During Centrifuge Training: Finding of Osteopenia

Low¹,

Teoh²,

Loh³

et al. 2008

aviat space environ med

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We report on a case of an F-16 pilot who suffered a compression fracture of the L5 vertebral body during centrifuge training. The pilot sustained the injury during a rapid onset to 6 G run. He was subsequently diagnosed to have osteopenia with a bone mineral density T-score of -1.95. This report discusses the medical and operational management of the pilot with this rare condition. The pilot has since returned to flying duties, albeit in a transportplatform.

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Young patients with hip fracture: a population-based study of bone mass and risk factors for osteoporosis

Cited by 37 publications

References 29 publications

Low bone mineral density and fat‐free mass in younger patients with a femoral neck fracture

Low bone mineral density and fat‐free mass in younger patients with a femoral neck fracture

Increased Risks of Hip Fracture in Diabetic Patients of Taiwan

Vertebral Fracture in a Pilot During Centrifuge Training: Finding of Osteopenia

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