Young Investigator: Psychiatric Conditions Are Associated With Medical Noncompliance and Worsening Disease Course in IBD Patient Population

Lee, Eun Jai; Rt, Abboud; Larion, Sebastian; Jim, McPhail; White, Bradley; Sifuentes, Humberto

doi:10.14309/00000434-201802001-00085

Cited by 2 publications

(3 citation statements)

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“…Of these, 26 studies were in adult populations, 1 was in an adolescent population, and 8 did not specify the age of the population. The prevalence by country (for 27 studies) is summarized in Figure 2A/ Supplemental Table 1 [5,[7][8][9]16,20,, while the remaining 8 studies (all conference abstracts) [42,[64][65][66][67][68][69][70] did not specify the country. A few studies found the prevalence rates ranged between 39.5% and 44.4% for psychosocial comorbidities (including anxiety and depression) in patients with IBD [71][72][73].…”

Section: Prevalence Of Anxiety and Depression In Patients With Ibdmentioning

confidence: 99%

“…Of these, 20 studies were in adult populations and 5 did not specify the age of the population. The prevalence of anxiety by country is summarized in Figure 2B/Supplemental Table 2 [7,9,16,20,[43][44][45][46][47][48][49][50][51][52][53][54][55][56]58,62,63], while the remaining 4 studies (all conference abstracts) [65,66,70,74] did not specify the country.…”

Section: Prevalence Of Anxiety and Depression In Patients With Ibdmentioning

confidence: 99%

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Burden of comorbid anxiety and depression in patients with inflammatory bowel disease: a systematic literature review

Dubinsky

Dotan

Rubin

et al. 2021

Expert Review of Gastroenterology & Hepatology

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Introduction Patients with inflammatory bowel disease (IBD), including Crohn's disease and ulcerative colitis, often have comorbid anxiety and depression that affects their quality of life (QoL) and management of their IBD. Areas covered A systematic literature review (SLR) was conducted to identify articles and conference abstracts on comorbid anxiety and depression in IBD patients using MEDLINE ® and Embase ® (January 2003 − June 2018). The impact of these psychological comorbidities on QoL and economic burden was examined. Non-pharmacologic interventions and disease-specific unmet clinical needs associated with these comorbidities were also evaluated. Expert opinion There is evidence that individual and group-based cognitive behavioral therapy can reduce rates of anxiety and depression in adults and adolescents with IBD. Patients with IBD and anxiety or depression had an increased risk of hospitalization, emergency department visits, readmission, and used outpatient services more often than people without these conditions. Several disease-specific unmet clinical needs for IBD patients were identified. These included lack of reimbursement for mentalhealth care, inconsistent screening for psychological comorbidities and patients not consulting mentalhealth professionals when needed. IBD patients may benefit from integrated medical and psychological treatment, and should be considered for behavioral treatment. Plain Language Summary Background People with IBD may have mental-health conditions, such as anxiety and depression. These conditions can affect people's quality of life and how they manage their IBD. What did this review look at?We found 79 publications on anxiety or depression in people with IBD, published between January 2003 and June 2018.In people with IBD and anxiety or depression, researchers looked at:the impact on health-related quality of life and healthcare utilization, including access to and reimbursement for mental-health services how effective interventions that do not involve the use of medicines were (known as non-pharmacologic therapy). What were the main findings from this review? People with IBD and anxiety or depression were more likely to be admitted to hospital and visit emergency departments than people without these conditions.Access to mental-health care varied and some people with IBD were not screened for depression. Individual and group-based talking therapy (known as cognitive behavioral therapy) reduced rates of anxiety and depression in some people with IBD. What were the main conclusions from this review?We found evidence that people with IBD and anxiety or depression may benefit from certain nonpharmacologic interventions. However, many people with IBD and anxiety or depression did not have access to mental-health services.Healthcare professionals should address gaps in patient care to improve outcomes in people with IBD and anxiety or depression. See Additional file 1 for an infographic plain language summary.

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Section: Prevalence Of Anxiety and Depression In Patients With Ibdmentioning

confidence: 99%

Section: Prevalence Of Anxiety and Depression In Patients With Ibdmentioning

confidence: 99%

Burden of comorbid anxiety and depression in patients with inflammatory bowel disease: a systematic literature review

Dubinsky

Dotan

Rubin

et al. 2021

Expert Review of Gastroenterology & Hepatology

View full text Add to dashboard Cite

show abstract

“…Gray et al [ 18 ] conducted a study on adolescents with IBD demonstrated that depression and anxiety symptoms may significantly affect the treatment adherence negatively, and consequently may contribute to poor disease control. In a study carried out in outpatient settings involving adults with IBD, having comorbid psychiatric diagnoses were noted as risk factors for medical non-compliance and also predisposed to severe disease progression [ 19 ].…”

Section: Discussionmentioning

confidence: 99%

Rising Burden of Psychiatric and Behavioral Disorders and Their Adverse Impact on Health Care Expenditure in Hospitalized Pediatric Patients with Inflammatory Bowel Disease

Thavamani

Khatana

Umapathi

et al. 2023

Pediatr Gastroenterol Hepatol Nutr

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Purpose The incidence and prevalence of inflammatory bowel disease (IBD) are increasing along with an increasing number of patients with comorbid conditions like psychiatric and behavioral disorders, which are independent predictors of quality of life. Methods Non-overlapping years (2003-2016) of National Inpatient Sample and Kids Inpatient Database were analyzed to include all IBD-related hospitalizations of patients less than 21 years of age. Patients were analyzed for a concomitant diagnosis of psychiatric/behavioral disorders and were compared with IBD patients without psychiatric/behavioral disorder diagnoses for outcome variables: IBD severity, length of stay and inflation-adjusted hospitalization charges. Results Total of 161,294 IBD-related hospitalizations were analyzed and the overall prevalence rate of any psychiatric and behavioral disorders was 15.7%. Prevalence rate increased from 11.3% (2003) to 20.6% (2016), p <0.001. Depression, substance use, and anxiety were the predominant psychiatric disorders. Regression analysis showed patients with severe IBD (odds ratio [OR], 1.57; confidence interval [CI], 1.47–1.67; p <0.001) and intermediate IBD (OR, 1.14; CI, 1.10–1.28, p <0.001) had increased risk of associated psychiatric and behavioral disorders than patients with a low severity IBD. Multivariate analysis showed that psychiatric and behavioral disorders had 1.17 (CI, 1.07–1.28; p <0.001) mean additional days of hospitalization and incurred additional $8473 (CI, 7,520–9,425; p <0.001) of mean hospitalization charges, independent of IBD severity. Conclusion Prevalence of psychiatric and behavioral disorders in hospitalized pediatric IBD patients has been significantly increasing over the last two decades, and these disorders were independently associated with prolonged hospital stay, and higher total hospitalization charges.

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Young Investigator: Psychiatric Conditions Are Associated With Medical Noncompliance and Worsening Disease Course in IBD Patient Population

Cited by 2 publications

References 0 publications

Burden of comorbid anxiety and depression in patients with inflammatory bowel disease: a systematic literature review

Burden of comorbid anxiety and depression in patients with inflammatory bowel disease: a systematic literature review

Rising Burden of Psychiatric and Behavioral Disorders and Their Adverse Impact on Health Care Expenditure in Hospitalized Pediatric Patients with Inflammatory Bowel Disease

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