This article assesses the effect of multimedia instructions on the academic performance of secondary and higher secondary school students in a developing country. The total sample size was 600, and the respondents were the secondary and higher secondary school students of Bangladesh. Data was collected through self-administered questionnaires. Finally, data analysis was performed using a two stage structural equations modelling approach. As per the study results, communicative and interactive class atmosphere (CIC), motivational teaching method (MTM), memorizable study materials (MSM), organized class lecture (OLC) of multimedia instruction have directly positive relationship with academic performance of secondary and higher secondary students. The findings of the current research applies to policy makers, school administrators, researchers, as well as academicians. This research presented a conceptual model which has been examined and validate of a developing country. The outcomes suggested both theoretical and practical implications.