Young Children Formula Consumption and Iron Deficiency at 24 Months in the General Population: A National Study

Clinical Prediction of Iron Deficiency at Age 2 Years: A National Cross-sectional Study in France

“…The present study is a planned ancillary analysis of a French cross-sectional observational study aiming at evaluating the effectiveness of a national ID prevention strategy based on using iron-fortified formula at weaning (16). The study protocol was approved by local ethics and administrative authorities (CPP IDF III no.…”

“…We used Stata/SE 13.1 (StataCorp, College Station, Texas) for data analysis and R 3.6.2 software for internal validation. Sample size calculation was performed for the primary objective of the study (16), and no a posteriori calculation was performed for this ancillary analysis.…”

“…From January 2016 to December 2017, 58 primary care pediatricians throughout 16 French regions were asked to include 10 consecutive patients (Appendix 2), aged from 22 to 26 months, living in France, with health insurance coverage (16). Children were excluded if they were known to have any chronic disease that may affect iron metabolism (e.g., celiac disease; complete list in Appendix 3).…”

“…Socio-demographic data, medical history, and past and current dietary habits were collected by the investigator at inclusion (16). A fasting blood sample was taken in a nearby laboratory.…”

“…Serum ferritin and CRP measurements were centralized in a unique laboratory (CERBA laboratory, Saint-Ouen l'Aumône, France) (16). In case of fever or any other condition that could alter the biological iron status (e.g., bronchiolitis, gastroenteritis), the blood sampling was postponed to 15 days after discontinuation of symptoms.…”