Young Age Is an Independent Prognostic Factor for Survival of Sporadic Renal Cell Carcinoma

Sánchez-Ortiz, Ricardo; Rosser, Charles J.; Madsen, Lydia T.; Swanson, David A.; Wood, Christopher G.

doi:10.1097/01.ju.0000125487.96469.2e

Cited by 72 publications

(72 citation statements)

References 14 publications

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“…Unfortunately, we cannot directly compare the results of our study with those in other cohorts becaused none used similar methodology. Despite the methodological distinctness of our study, we did corroborate the findings of Sánchez-Ortiz and colleagues 3 and of Taccoen and colleagues, 4 namely, that young age exerts a protective effect against RCC-SM. The novelty of our findings resides in the breakpoints that differ from previous studies that used the age of 40 years as a cut-off.…”

Section: Discussionsupporting

confidence: 81%

“…3,10,12,13 Recently, 2 studies indicated that better survival could be expected in young patients and that age was an independent predictor of RCC-SM. 3,5 These 2 studies involved 106 and 4774 patients, respectively. Both used an age cutoff of 40 years, which was consistent with cut-offs tested in previous studies of RCC and with cut-offs used in studies of other cancers.…”

Section: Discussionmentioning

confidence: 99%

“…2 Recently, 2 groups of investigators assessed the effect of age on renal cell carcinoma-specific mortality (RCC-SM) in a combined cohort of 4880 patients. [3][4][5] Although these findings are interesting, the cut-offs used to assess the effect of age were not based on specific RCC biology. Instead they were adapted from literature addressing other types of cancer.…”

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confidence: 99%

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Age at diagnosis is a determinant factor of renal cell carcinoma– specific survival in patients treated with nephrectomy

Karakiewicz

Jeldres

Suardi

et al. 2008

CUAJ

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Objective: Based on combined data for 4880 patients, 2 previous studies reported that advanced age is a predictor of increased renal cell carcinoma-specific mortality (RCC-SM). We explored the effect of age in cubic spline analyses to identify the age groups with the most elevated risk for renal cell carcinoma (RCC). Methods:Our study included 3595 patients from 14 European centres who had partial or radical nephrectomies. We used the Kaplan-Meier method to compile life tables, and we performed Cox regression analyses to assess RCC-SM. Covariates included age at diagnosis, sex, TNM (tumour, node, metastasis) stage, tumour size, Fuhrman grade, symptom classification and histological subtype.

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Section: Discussionsupporting

confidence: 81%

Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

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Age at diagnosis is a determinant factor of renal cell carcinoma– specific survival in patients treated with nephrectomy

Karakiewicz

Jeldres

Suardi

et al. 2008

CUAJ

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“…Despite no agreement on the exact age limit in order to consider patients with RCC as young adults. Several studies accepts 35-45 years as the upper limit [2,6,10] and 14-26 as the lower limit [1][2][3]7,11]. Additionally, some of the studies even included benign lesions of the kidney in their series [5,12] which we think affect interpretation of results.…”

Section: Discussionmentioning

confidence: 99%

Clinicopathological features and survival rates of patients with renal cell carcinoma under 50 years of age

Atmaca¹,

Bayrak

Kandemir³

et al. 2008

Open Medicine

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AbstractWe analyzed the clinicopathological features and survival rates of the patients with renal cell carcinoma younger than 50 years old. Between 2004 and 2007, 28 patients between 19–49 years underwent surgery for renal cell carcinoma. Presenting symptoms, type of the surgery performed, postoperative outcomes and duration of follow-up were recorded. Mean age was 41.5±7.6 years and 75% of patients were male. The tumor was symptomatic in 19(67.9%) and incidental in 9(32.1%) patients. Radical nephrectomy and nephron-sparing surgery were performed in 18(64.3%) and 10(35.7%) patients, respectively. The most common histologic type was clear cell(67.9%). The mean tumor diameters were 3.5±0.95 and 7.4±5.2 cm in the incidental and symptomatic groups, respectively(p=0.035). Incidentally discovered tumors and tumors treated by NSS did not include Fuhrman grade 4. There were no differences regarding pathological stage and Fuhrman grades when patients were grouped according to their symptomatology(p=0.242 and p=0.265, respectively). Overall mortality was 17.9%(n=5) whereas 4 patients(14.3%) died because of cancer. The mean survival was 30.6 months and cancer specific survival rate was 85.2%. Most of the tumors in this age group were symptomatic and most common histologic subtype was clear cell carcinoma. Incidentally discovered tumors had statistically significant lower tumor size.

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“…[4][5][6] This association has previously been validated in renal cell carcinoma. 7,8 It is possible that such tumours in younger patients are associated with more aggressive genomic alterations. 9,10 However, these hypotheses have never been tested in the context of UCUB.…”

Section: Introductionmentioning

confidence: 99%

Age-stratified distribution of metastatic sites in bladder cancer: A population-based analysis

Bianchi¹,

Roghmann²,

Becker³

et al. 2014

CUAJ

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Introduction: Urothelial carcinoma of the urinary bladder (UCUB) is the most common malignancy of the urinary tract. We examined the distribution of site-specific metastases in patients with UCUB according to age and we assessed contemporary recommendations proposed by guidelines with regard to distant metastases. Methods: Patients with metastatic UCUB (mUCUB) were abstracted from the Nationwide Inpatient Sample (1998)(1999)(2000)(2001)(2002)(2003)(2004)(2005)(2006)(2007). Age was stratified into quartiles: ≤63, 64-72, 73-79 and ≥80 years. CochranArmitage trend test and multivariable logistic regression analysis tested the relationship between age and the rate of metastases. Finally, we identified patients at high risk of brain or bone metastases. Results: Within 7543 patients with mUCUB, 25%, 24%, 23%, 19%, 18% and 3% had lymph node, bone, urinary, lung and liver metastases, respectively. Overall, the rate of concomitant metastases was 29%. The rate of multiple metastatic sites decreased with increasing age (p < 0.001). This was confirmed in patients with lung, bone, liver, urinary system and brain metastases (all p ≤ 0.04). The rate of bone metastases was 15.0% in patients with exclusive abdominal metastases and 40.0% in patients with abdominal, thoracic and brain metastases. The rate of brain metastases was 1% in patients with exclusive abdominal metastases and 7% in patients with thoracic and bone metastases. Our findings are limited by the retrospective nature of the analyses. Conclusions: We report a higher number of concomitant metastatic sites in young UCUB patients. Bone metastases are frequent in all patient groups, whereas brain metastases are common in UCUB patients with thoracic and/or bone metastases.

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Young Age Is an Independent Prognostic Factor for Survival of Sporadic Renal Cell Carcinoma

Cited by 72 publications

References 14 publications

Age at diagnosis is a determinant factor of renal cell carcinoma– specific survival in patients treated with nephrectomy

Age at diagnosis is a determinant factor of renal cell carcinoma– specific survival in patients treated with nephrectomy

Clinicopathological features and survival rates of patients with renal cell carcinoma under 50 years of age

Age-stratified distribution of metastatic sites in bladder cancer: A population-based analysis

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