You may need the vagus nerve to understand pathophysiology and to treat diseases

Couck, Marijke; Mravec, Boris; Gidron, Yori

doi:10.1042/cs20110299

Cited by 78 publications

(80 citation statements)

References 45 publications

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“…Therefore, these findings suggest that in cancer patients, vagal function deteriorates as the tumor burden increases. De Couck et al also observed low vagal function in advanced stage compared to the early stage of cancer but involving only r-MSSD as an indicator for vagal function whereas our study involved both E:I ratio and r-MSSD [4]. Their study population included comorbid conditions such as cardiovascular disease and diabetes which are known to influence vagal function indicators whereas our study populations were only with cancer.…”

Section: Discussionmentioning

confidence: 61%

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Influence of Cancer Severity and Functional Status of Cancer on Cardiac Parasympathetic Indicators

Bijoor

Banerjee

Subbalakshmi

2017

Asian J Pharm Clin Res

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Objective: To investigate the influence of cancer severity and functional status of cancer patients on cardiac parasympathetic indicators. Methods:A total of 267 patients with a fresh clinical diagnosis of solid malignant tumor not yet put on cancer therapy and 250 controls matched for age, sex of study subjects were included. Severity of cancer was defined based on the American Joint Committee on Cancer staging. Accordingly, study subjects were subdivided into early stage (Stage I and II combined) and advanced stage (Stage III and IV combined). In cancer patients, the Eastern Cooperative Oncology Group (ECOG) performance score and the Faces Pain Scale score (FPS) was noted. Two indicators of vagal function, expiratory:inspiratory ratio (E:I ratio) and root mean square of successive N-N interval difference (r-MSSD) were included. E:I ratio during deep breathing at six respiratory cycles/minute and r-MSSD at rest was obtained from 1 minute lead II electrocardiogram. Data were analyzed by applying suitable statistical tests. p≤0.05 was considered significant.Results: R-MSSD and E:I ratio was significantly reduced in the early and advanced stage of cancer compared to controls (p≤0.0001). r-MSSD and E:I ratio was significantly reduced in advanced stage compared to the early stage of cancer (p≤0.0001). r-MSSD and E:I ratio was significantly different in subgroups of stages of cancer and controls (p≤0.0001). In cancer patients, r-MSSD was negatively correlated with ECOG and FPS score (p≤0.0278, p≤0.0100). Conclusion:Severity of cancer affects vagal function. However, r-MSSD alone was associated with functional status (ECOG, FPS) of cancer patients.

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Section: Discussionmentioning

confidence: 61%

“…ANS controls most of the viscera, and many solid cancers are formed in the same viscera [3,4]. Consequently, recent studies have revealed autonomic dysfunction in cancer patients [5].…”

Section: Introductionmentioning

confidence: 99%

Influence of Cancer Severity and Functional Status of Cancer on Cardiac Parasympathetic Indicators

Bijoor

Banerjee

Subbalakshmi

2017

Asian J Pharm Clin Res

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“…The effects of vagal nerve activity on clinical outcomes were hypothesized to occur as a result of the known inhibitory roles of this nerve on three mechanisms promoting tumor onset and progression (excessive inflam mation, excessive sympathetic activity and oxidative stress) (21). Vagal nerve activity was indexed by heart rate variability (HRV) obtained from a 10 sec ECG at approximately the time of cancer diagnosis.…”

Section: Discussionmentioning

confidence: 99%

“…Finally, the metastatic process is also under the control of sympathetic neurotransmitters, which influence the migratory ability of cancer cells and determine the direction and the development of metastases (16). Vagal nerve activity is inversely related to and inhibits all these three mechanisms (17)(18)(19)(20)(21). Based on converging evidence, Gidron et al (22) hypothesized that vagal nerve activity may modulate tumor growth, and if this model is valid, might become a variable that could be used as a prognostic factor and could be therapeutically manipulated.…”

Section: Introductionmentioning

confidence: 99%

The relationship between vagal nerve activity and clinical outcomes in prostate and non-small cell lung cancer patients

Couck¹,

Brummelen²,

Schallier³

et al. 2013

Oncology Reports

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Abstract. Recent studies suggest that vagal nerve activity, indexed by heart rate variability (HRV), could have a prognostic role in cancer. However, most studies did not control adequately for confounders and included cardiac patients. Furthermore, the validity of this prognostic role needs to be tested in different types of cancer. The present study tested the prognostic role of HRV in prostate cancer (PC) and non-small cell lung cancer (NSCLC) patients, using a historical prospective design. HRV was derived from brief 10 sec ECGs obtained at approximately the time of diagnosis in 113 PC patients and 133 NSCLC patients. Outcomes included prostate-specific antigen (PSA) at 6 and 24 months in PC, and overall survival (OS) (for the full sample) and survival time (for the deceased patients) in NSCLC. Furthermore, the possible mediating role of C-reactive protein (CRP) was tested (in NSCLC), as well as whether age and stage moderated the relationship between HRV and prognosis in both types of cancer. In the PC patients, HRV significantly inversely predicted PSA levels at 6 and 24 months, independent of confounders. Furthermore, this was particularly significant in metastatic PC patients, indicating moderation by stage. In NSCLC patients, HRV did not predict OS and survival time, but it did positively predict survival time in patients under the age of 65, independent of confounders. Additionally, CRP was not found to mediate the relationship between HRV and OS or survival time in NSCLC. The present results partly support previous studies and extend them to two additional common types of cancer, using a more rigorous control over confounders. Together with recent experimental findings, these results propose a modulatory role of vagal nerve activity in cancer. Therefore, routine measurement of HRV in estimating prognosis in cancer may be considered.

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“…In male patients with locally recurrent or metastatic cancer (principally lung and gastrointestinal cancer) a higher HRV is significantly associated to survival; in patients with different cancer sites, HRV appears systematically decreased; in patients with terminal hepatocellular carcinoma, HRV indices were significantly associated with Time-toDeath [48][49][50]. This influence can be understood since Vagal afferents and efferents might inhibit three mechanisms involved in cancer etiology and progression: local oxidative stress and DNA damage, inflammatory reactions and excessive sympathetic responses [51].…”

Section: Hrv and Pathology: Influences And Interventionmentioning

confidence: 99%

Towards an integrated model of defense in gynecological cancer. Psychoneuroimmunological and psychological factors, between risk and protection in cancer: A review

Cosentino¹,

Pruneti²

2015

Integr Cancer Sci Therap

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Current cancer conceptualization and management focuses it as a chronic disease that could be directly modulated by psychosocial stressors. An individual is considered a cancer survivor from the time of diagnosis and from the balance of his or her life, including health, mental states, identity, sexuality and financial standings. Moving within the theoretical frames of Psycho-oncology and Psychoneuroimmunology (PNI), this review aims to analyze, in cancer population and in the specific subsample of ovarian cancer, literature regarding PNI pathways as cancer exacerbating factors, PNI pathways promoting cancer survivorship, adaptive psychological variables linked to Quality of Life and specific areas of psychological pain. Scientific books and full-text articles published in English between 2003-2013were collected. Evidences were collected of the key role of the stress activation main secretions on tumorigenesis and tumor progression, highlighting the role of life events coping. Evidences of the protective role of Parasympathetic Nervous System activation, expressed through the Heart Rate Variability in cancer survivorship and quality of life were also collected. Were detected the main psychological issues in cancer and specific critical psychological sufferance for Ovarian Cancer (sexual impairments, body image alterations). Was also identified the protective central role of Social Support in cancer adjustment. This literature systematic review seems to give the possibility to hypothesize a new model, here called "Integrated Model of Defense" which, integrating psychological and physiological factors, could suggest a protective mechanism in time and quality of survivorship in cancer and, more specifically, in Gynecological Cancer.

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You may need the vagus nerve to understand pathophysiology and to treat diseases

Cited by 78 publications

References 45 publications

Influence of Cancer Severity and Functional Status of Cancer on Cardiac Parasympathetic Indicators

Influence of Cancer Severity and Functional Status of Cancer on Cardiac Parasympathetic Indicators

The relationship between vagal nerve activity and clinical outcomes in prostate and non-small cell lung cancer patients

Towards an integrated model of defense in gynecological cancer. Psychoneuroimmunological and psychological factors, between risk and protection in cancer: A review

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