You’ll see it when you know it: granulomatous mastitis

Smith, Elana B.; Moore, Dan; Jordan, Sheryl G.

doi:10.1007/s10140-021-01931-4

Cited by 5 publications

(3 citation statements)

References 20 publications

(45 reference statements)

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“…Occasionally, a typical granuloma may be absent, and only a histiocytic infiltrate is present. Common staining methods such as PAS, Grocott, and Ziehl yield negative results [ 12 ].…”

Section: Discussionmentioning

confidence: 99%

Idiopathic granulomatous mastitis: A challenging case report and comprehensive review of the literature

Benlghazi,

Messaoudi,

Belouad

et al. 2024

International Journal of Surgery Case Reports

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“…Occasionally, a typical granuloma may be absent, and only a histiocytic infiltrate is present. Common staining methods such as PAS, Grocott, and Ziehl yield negative results [ 12 ].…”

Section: Discussionmentioning

confidence: 99%

Idiopathic granulomatous mastitis: A challenging case report and comprehensive review of the literature

Benlghazi,

Messaoudi,

Belouad

et al. 2024

International Journal of Surgery Case Reports

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“…Although previous studies showed the long-lasting condition of NPM and the potential repeated breast surgeries could negatively affect the physical and mental health of patients with higher medical costs [24] , few studies have provided a comprehensive description of severe NPM episodes. Most of the previous studies are case reports and are limited in sample size, data quality, valid study design, and analysis [3] , and only described the characteristics of NPM [25,26] . Few studies further investigated the risk factors associated with NPM severity.…”

Section: Introductionmentioning

confidence: 99%

Prolactin and Non-Puerperal Mastitis: A Multimethodology Observational Study Using Real-World Data

Yin

Cheng

et al. 2023

Preprint

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Background Non-puerperal mastitis (NPM) is an umbrella term for non-specific inflammatory mastitis inflammation with unclear etiology. The objective of the current study is to characterize NPM patients and examine the determinants associated with NPM severity. Methods This study analyzed the NPM inpatients admitted to the Department of Breast Surgery, Longhua Hospital Affiliated with Shanghai University of Traditional Chinese Medicine from 2016 to 2020. We explored NPM patient characteristics through demographics, physical risks, lab tests, and medical history indicators. Multivariable logistic regression was conducted to identify the relationship between the prolactin (PRL) level and NPM severity stratified by breast structure. Findings The majority of NPM inpatients had normal breast structures and were of lower average age than those with congenital nipple deformity (p=0.002). Significant positive risk (p< 0.001) association between PRL level and NPM severity was observed among NPM inpatients with normal breast structure in both binomial (OR: 2.91; 95%CI:1.88-4.52) and ordinal regression model (OR: 3.47; 95%CI:2.39-5.08), with age as a protective factor (OR:0.94; 95%CI:0.91-0.97). For NPM patients with nipple deformity, increasing odds of NPM severity regarding higher PRL level was only observed in ordinal logistic regression, which was lower (OR: 2.21; 95%CI: 1.14-4.34; p=0.02) than their peer with normal breast structure. Interpretation The risk of NPM severe episodes is higher among patients with higher PRL levels, of which the association is stronger for NPM patients with normal breast structure, implying different pathogenesis between NPM patients with varied breast anatomy. Testification of the analysis model indicates an improvement window for the current NPM severity assessment. Funding This study was supported by the second major clinical research project of "Three-year Action Plan for Promoting Clinical Skills and Clinical Innovation in Municipal Hospitals (2020-2022)" (SHDC2020CR2051B), the National Natural Science Foundation of China (No.82104854), and Shanghai Sailing Program (20YF1449800).

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“…Although previous studies showed the long-lasting condition of NPM and the potential repeated breast surgeries could negatively affect the physical and mental health of patients with higher medical costs [24] , few studies have provided a comprehensive description of severe NPM episodes. Most of the previous studies are case reports and are limited in sample size, data quality, valid study design, and analysis [3] , and only described the characteristics of NPM [25,26] . Some evidence illustrated that increasing prolactin (PRL) level is highly related to NPM reoccurrence [27,28] , but few studies focused on the association between PRL level and NPM severity of rst time onset, or further investigated risk factors among NPM patients who need surgical treatment.…”

mentioning

confidence: 99%

Prolactin And Non-Puerperal Mastitis: A Cohort Study Using Real-World Data

yin,

Le,

Cheng

et al. 2024

Preprint

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Objective Non-puerperal mastitis (NPM) is an umbrella term for non-specific inflammatory mastitis inflammation with unclear etiology. The objective of the current study is to characterize NPM patients and examine the determinants associated with NPM severity. Method This study analyzed the NPM inpatients admitted to the Department of Breast Surgery, Longhua Hospital Affiliated with Shanghai University of Traditional Chinese Medicine from 2016 to 2020. We explored NPM patient characteristics through demographics, physical risks, lab tests, and medical history indicators. Multivariable logistic regression was conducted to identify the relationship between the prolactin (PRL) level and NPM severity stratified by breast structure. Result The majority of NPM inpatients had normal breast structures and were of lower average age than those with congenital nipple deformity (p = 0.002). Significant positive risk (p < 0.001) association between PRL level and NPM severity was observed among NPM inpatients with normal breast structure in both crude and adjusted model(adjusted OR: 2.91; 95%CI:1.88–4.52), with age as a protective factor (OR:0.94; 95%CI:0.91–0.97) and smoking history as a risk factor(OR:2.22; 95%CI:1.22–4.05). For NPM patients with nipple deformity, increasing odds of NPM severity regarding higher PRL level was observed while the result is not statistic significant at 0.05 level. (OR: 2.17; 95%CI: 0.94–5.03; p = 0.076). Conclusion The risk of NPM severe episodes is higher among patients with higher PRL levels, of which the association is stronger for NPM patients with normal breast structure, implying different pathogenesis between NPM patients with varied breast anatomy. Disagreement of the interaction effect testification indicates an improvement window for current study. Trial registration ChiCTR2000035929. Registered 20 August 2020(retrospectively registered).

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You’ll see it when you know it: granulomatous mastitis

Cited by 5 publications

References 20 publications

Idiopathic granulomatous mastitis: A challenging case report and comprehensive review of the literature

Idiopathic granulomatous mastitis: A challenging case report and comprehensive review of the literature

Prolactin and Non-Puerperal Mastitis: A Multimethodology Observational Study Using Real-World Data

Prolactin And Non-Puerperal Mastitis: A Cohort Study Using Real-World Data

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