The ubiquity of mobile devices allows researchers to assess people’s real-life behaviors objectively, unobtrusively, and with high temporal resolution. As a result, psychological mobile sensing research has grown rapidly. However, only very few cross-cultural mobile sensing studies have been conducted to date. In addition, existing multi-country studies often fail to acknowledge or examine possible cross-cultural differences. In this chapter, we illustrate biases that can occur when conducting cross-cultural mobile sensing studies. Such biases can relate to measurement, construct, sample, device type, user practices, and environmental factors. We also propose mitigation strategies to minimize these biases, such as the use of informants with expertise in local culture, the development of cross-culturally comparable instruments, the use of culture-specific recruiting strategies and incentives, and rigorous reporting standards regarding the generalizability of research findings. We hope to inspire rigorous comparative research to establish and refine mobile sensing methodologies for cross-cultural psychology.