Yolk sac tumor of endometrium: A case report and literature review

Lin, Shih‐Wen; Hsieh, Shu-Wei; Huang, Shih‐Hung; Liang, Hung-Shuo; Huang, Chia-Yen

doi:10.1016/j.tjog.2019.09.020

Cited by 13 publications

(9 citation statements)

References 16 publications

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“…According to limited studies on uterine YSTs, a combination of radical surgery and chemotherapy seems to be the first-line treatment ( 10 , 22 , 39 ) and may result in better survival ( 22 ). However, the specific range remains undefined ( 10 , 40 ) and whether the uterus and ovaries can be preserved still needs further exploration ( 10 , 41 ).…”

Section: Discussionmentioning

confidence: 99%

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Preservation of sexual and reproductive function in the treatment of extragonadal yolk sac tumors in the female genital tract

Cao

Peng

et al. 2022

Front. Pediatr.

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ObjectiveThis study aimed to summarize the clinical features, treatment modalities, therapeutic effects, menstruation and fertility outcomes, and prognosis of extragonadal yolk sac tumors (YSTs) of the female genital tract.MethodsWe reviewed 32 cases of extragonadal YSTs in the genital tract treated between 1983 and 2021. The medical records, including clinical characteristics, histopathology, treatments, chemo-reduced adverse events, and outcomes on long-term follow-up, were collected.ResultsAmong the 32 cases, 30 were vaginal YSTs and two were uterine YSTs (endometrial and cervical). Thirty patients (30/32, 93.8%) were <4 years. Abnormal vaginal bleeding (n = 31) and elevated serum alpha-fetoprotein level (n = 32) were the most common presentations. Vaginohysteroscopy and/or pediatric rhinoscopy were used for diagnosis in 17 pediatric patients and evaluation of chemotherapeutic efficacy in 21 pediatric patients. All the patients received combination chemotherapy. Bleomycin/etoposide/cisplatin (BEP) was chosen with prior consideration in 28 cases; 21 patients were treated with BEP alone. Yellow or grayish-yellow tissue with irregular shape was found in 66.7% of the cases during repeat examinations. Five patients underwent surgeries during repeat examinations and follow-ups, and no evidence of malignancy was noted in them. Thirty-one patients achieved complete remission. During a median follow-up of 63 months (2.4–240.3 months), two patients experienced recurrence, three died, and 29 remained disease-free. One patient recovered menstruation and five had undergone menarche.ConclusionBEP chemotherapy can serve as a preferred treatment modality for vaginal and uterine YSTs. Vaginohysteroscopy and pediatric rhinoscopy can be used for diagnosis and evaluation of chemotherapeutic efficacy in pediatric patients. YSTs possibly appear as yellow or grayish-yellow after chemotherapy.

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Section: Discussionmentioning

confidence: 99%

“…Vaginal YSTs are locally aggressive and capable of hematogenous and lymphatic metastasis ( 22 , 23 , 29 , 30 ). Early detection and appropriate therapy are key to improving prognosis.…”

Section: Introductionmentioning

confidence: 99%

Preservation of sexual and reproductive function in the treatment of extragonadal yolk sac tumors in the female genital tract

Cao

Peng

et al. 2022

Front. Pediatr.

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“…Yolk sac tumour (YST) is the second most common ovarian germ cell tumour and usually occurs in infants and adolescents [1,2]. These tumours are typically found in the gonads and areas with a primitive extraembryonic morphology, but YSTs involving the endometrium and combined with epithelial ovarian carcinoma are extremely rare [3,4]. There are no guidelines for the treatment of malignant gynaecological tumours with YST components.…”

Section: Introductionmentioning

confidence: 99%

Cases of Yolk sac tumor associated with gynecological malignant tumor

Wang

Chen

et al. 2023

Preprint

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Background: Yolk sac tumour (YST) is the second most common ovarian germ cell tumour and usually presentsin children and young women. However, tumours rarely occur as malignant gynaecological tumourswith YST components. Case presentation: We present one case of endometrioid carcinoma and clear cell carcinoma with YST components and two other cases of YSTs associated with high-grade serous carcinoma of the ovary in females. After surgery and adjuvant chemotherapy, the patient withendometrioid carcinoma had progressive disease and died 20 months later,and the other two were still alive at thelast follow-up. Conclusions: To our knowledge, these mixed neoplasm associations areunusual,and these cases illustrate the diagnosis and prognosis of YST associated with malignant gynaecological tumours, emphasizing early recognition and aggressive treatment.

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“…Extragonadal YST occasionally arise from the sacrococcygeal region, mediastinum, retroperitoneum, and the female reproductive tract 1 . Primary yolk sac tumor arising from the uterus is an extremely rare condition, to our best knowledge, only 27 cases have been reported in the English literature (Table 1) [2][3][4][5][6][7][8][9][10][11][12][13][14][15][16][17] . Here, we present a rare case of extragonadal YST occurring in the uterus of a 2-year-old girl, with a discussion of its clinical management in diagnosis and treatment.…”

Section: Introductionmentioning

confidence: 99%

Yolk sac tumor of the uterus in a 2-year-old girl: A case report and literature review

Yin

Wang

Yang

2022

Journal of Pediatric and Adolescent Gynecology

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Yolk sac tumor of endometrium: A case report and literature review

Cited by 13 publications

References 16 publications

Preservation of sexual and reproductive function in the treatment of extragonadal yolk sac tumors in the female genital tract

Preservation of sexual and reproductive function in the treatment of extragonadal yolk sac tumors in the female genital tract

Cases of Yolk sac tumor associated with gynecological malignant tumor

Yolk sac tumor of the uterus in a 2-year-old girl: A case report and literature review

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