Yolk Sac Tumor (Endodermal Sinus Tumor) and Alpha-Fetoprotein. A Report of Three Cases

Tsuchida, Yoshiaki; Saito, Sumio; Ishida, Masanobu; Ohmi, Kazuhiro; Urano, Yoshiyori; Endo, Yasuo; Oda, Tatsuya

doi:10.1097/00006254-197408000-00027

Cited by 8 publications

(10 citation statements)

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“…α‐Fetoprotein (AFP) is a major plasma protein synthesized by the fetal liver, yolk sac and by some fetal gastrointestinal cells 4 . AFP is not usually present in normal adult organs, but is found in some adult cancer cells such as HCC cells, yolk sac tumour cells and gastric cancer cells 5–7 . Recently, it has been reported that hepatocyte nuclear factor‐1 (HNF1) stimulates AFP transcription, whereas the Adenine Thymine motif binding factor‐1 (ATBF1) is a transcription suppressor.…”

Section: Introductionmentioning

confidence: 99%

“…4 AFP is not usually present in normal adult organs, but is found in some adult cancer cells such as HCC cells, yolk sac tumour cells and gastric cancer cells. [5][6][7] Recently, it has been reported that hepatocyte nuclear factor-1 (HNF1) stimulates AFP transcription, whereas the Adenine Thymine motif binding factor-1 (ATBF1) is a transcription suppressor. Interestingly, both factors competitively bind to the AT motif and regulate AFP transcription.…”

Section: Introductionmentioning

confidence: 99%

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Down‐regulation of ATBF1 is a major inactivating mechanism in hepatocellular carcinoma

et al. 2008

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Down‐regulation of ATBF1 is a major inactivating mechanism in hepatocellular carcinoma

et al. 2008

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“…The presence of elevated levels of serum AFP in some patients with germ cell neoplasms has been noted during the latter part of the last decade (Abelev et al, 1967;Masopust et al, 1968;Mawas et al, 1969) and, more recently, the association between the increased AFP production in patients with germ cell tumours composed of, or containing, elements of endodermal sinus tumour (yolk sac tumour) has been demonstrated, both in human tumours (Ballas, 1972;Tsuchida et al, 1973;Itoh et al, 1974;Talerman and Haije, 1974;N0rgaard-Petersen, Albrechtsen and Teilum, 1975) and in experimental tumours in mice (Hooghe et al, 1974). There have been only a few reports on the value of serum CEA determinations in patients with germ cell neoplasms (Reynoso et al, 1972;Wahren and Edsmyr, 1974).…”

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confidence: 96%

Alpha-foetoprotein and carcinoembryonic antigen in germ cell neoplasms

Talerman¹,

Pompe²,

Haije³

et al. 1977

Br J Cancer

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Serum alpha-foetoprotein (AFP) and serum carcinoembryonic antigen (CEA) levels were measured, serially whenever possible, in 70 patients attending the Institute of Radiotherapy, Rotterdam, on account of testicular (65) or ovarian (4) germ cell tumours or, in one case, an endodermal sinus (yolk sac) tumour in the mediastinum. In 15 patients the disease was active; in the others it was in remission. Patients with active disease had raised serum AFP levels which correlated well with disease activity; no patient without evidence of active disease had raised serum AFP levels. None of the patients with active disease was found to have raised serum CEA levels. There was no correlation between serum AFP and CEA levels in patients with germ cell neoplasms, but good correlation between serum AFP levels and disease activity. Serum CEA levels did not correlate with disease activity, and serial determinations would therefore not be useful in monitoring progress in this group of diseases.

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“…The reasons for this are unclear, but could be due to the presence of a specific population of cells in such teratomas. Yolk sac tumours in man and animals have been shown to contain or produce AFP (Ballas, 1972;Engelhardt, Poltoranina and Yazova, 1973;Hooghe and Zeicher, 1974;N0rgaard-Pederson, 1974, 1975), and isolated reports of high serum AFP levels with testicular tumours containing yolk sac (endodermal sinus) elements or polyembryoma have appeared (Abelev, 1974;Bourgeaux et al, 1971;Tsuchida et al, 1973;Teilum et al, 1974Teilum et al, , 1975.…”

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confidence: 99%

Serum alpha1-foetoprotein levels in 153 male patients with germ cell tumours

Grigor¹,

Detre²,

Kohn³

et al. 1977

Br J Cancer

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--alpha1-Foetoprotein (AFP) levels have been measured by radioimmunoassay in the serum of 153 male patients with gonadal and extragonadal germ cell tumours. Thirty-five patients with pure seminoma, and 34 patients with teratoma but without any postoperative evidence of residual or recurrent tumour, consistently had normal serum AFP levels (less than 25 ng/ml). Of 84 patients with active teratomas, 56 (67%) had serological evidence of AFP production. Ten patients with histological evidence of pure yolk sac (endodermal sinus) tumours all had raised levels. Teratomas containing yolk sac (elements may or may not be associated with raised serum levels. Trophoblastic (choriocarcinomatous) elements in a teratoma were not normally associated with high values. Fourteen patients with teratomas had elevated levels in the absence of histologically detectable yolk sac elements. Serum AFP levels often became elevated before clinical evidence of recurrence, so that AFP can act as an effective marker of the course of the disease and its response to therapy in many patients, but recurrent or progressive disease may be present in the absence of raised levels.

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Yolk Sac Tumor (Endodermal Sinus Tumor) and Alpha-Fetoprotein. A Report of Three Cases

Cited by 8 publications

References 0 publications

Down‐regulation of ATBF1 is a major inactivating mechanism in hepatocellular carcinoma

Down‐regulation of ATBF1 is a major inactivating mechanism in hepatocellular carcinoma

Alpha-foetoprotein and carcinoembryonic antigen in germ cell neoplasms

Serum alpha1-foetoprotein levels in 153 male patients with germ cell tumours

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