Yolk Sac Carcinoma, Rat

Sobis, H

doi:10.1007/978-3-642-72550-0_19

Cited by 10 publications

(15 citation statements)

References 17 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…3B, 3C, 3D), respectively. All of the morphological, histochemical, and immunohistochemical findings were highly comparable to the previously reported cases of yolk sac carcinoma in rodents 2 , 4 , 5 , 10 . PTAH staining was performed to differentiate the possibility of thrombi and produced a negative result.…”

supporting

confidence: 88%

“…The incidence of yolk sac carcinoma in rats is extremely low, with only 1 case occurring in more than 40,000 female F344 rats used in previous carcinogenicity studies 1 . There have been some other reports of yolk sac carcinomas that developed in the ovary or uterus in aged female rats 2 , 3 , 4 . Nakazawa and colleagues reported an instance of testicular yolk sac carcinoma in an aged Sprague-Dawley (SD) rat 5 .…”

mentioning

confidence: 99%

See 1 more Smart Citation

A case report of a metastatic yolk sac carcinoma in the pulmonary artery of a young female Sprague-Dawley rat

et al. 2016

View full text Add to dashboard Cite

Yolk sac carcinoma is an extremely rare tumor in rats and is usually found in the genital system of aged animals. We encountered a yolk sac carcinoma in the pulmonary artery of an 18-week-old female Sprague-Dawley rat. In a repeated dosing toxicity study (once weekly for 4 weeks, intraperitoneal), this rat was unexpectedly found dead on the 55th day after the final administration of the test article. At necropsy, grayish white nodules were found on the lung surface. Histopathologically, tumor emboli were observed in the trunk and branch of the pulmonary artery. Tumor cells with slightly basophilic vacuolated cytoplasm and large vesicular nuclei formed nests or clusters and were embedded in a homogenous eosinophilic and periodic acid-Schiff reaction positive matrix. The tumor cells and matrix were immunoreactive for laminin. The embolic tumor resembled yolk sac carcinoma showing a parietal pattern in rodents. Although the primary site was unknown, the tumor was considered to be a metastatic yolk sac carcinoma.

show abstract

supporting

confidence: 88%

mentioning

confidence: 99%

A case report of a metastatic yolk sac carcinoma in the pulmonary artery of a young female Sprague-Dawley rat

et al. 2016

View full text Add to dashboard Cite

show abstract

“…6 Uterine yolk sac tumors, derived from products of gestation, can be experimentally induced in rats by 1 of 4 methods involving transplantation of extraembryonic tissues or fetectomy. 3,12 Whereas germ cell tumors in the ovary are syngeneic with the dam (and always female), products of gestation may differ in 50% of alleles (and can be male). By immunohistochemistry, visceral cells are positive for a-fetoprotein (AFP), although AFP reaction has also been reported in parietal cells.…”

Section: Discussionmentioning

confidence: 99%

“…By immunohistochemistry, visceral cells are positive for a-fetoprotein (AFP), although AFP reaction has also been reported in parietal cells. 3,9,12 Tumor cells are also positive for keratin, while PAS-positive material is positive for laminin. 6,9 In humans, the most specific markers for yolk sac tumors are AFP and glypican 3.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Diagnostic Exercise

2013

View full text Add to dashboard Cite

A 1.4-year-old virgin female brown-hooded fancy rat presented for abdominal distention, jaundice, and dyspnea. At physical examination, a firm mass was palpable in the caudoventral abdomen as well as multiple small nodular masses associated with the abdominal viscera. At necropsy, in addition to a large mass replacing the left ovary and myriad nodules studding the peritoneal surface, there was 31 ml of abdominal effusion. By cytology, the abdominal fluid contained numerous pleomorphic vacuolated tumor cells surrounding globular pale eosinophilic to amphophilic acellular material that was strongly periodic acid-Schiff positive. Histologically, the tumor was biphasic with abundant acellular hyaline matrix that was also periodic acid-Schiff positive.

show abstract

One-year oral toxicity study on a genetically modified maize MON810 variety in Wistar Han RCC rats (EU 7th Framework Programme project GRACE)

et al. 2016

View full text Add to dashboard Cite

The GRACE (GMO Risk Assessment and Communication of Evidence; www.grace-fp7.eu) project was funded by the European Commission within the 7th Framework Programme. A key objective of GRACE was to conduct 90-day animal feeding trials, animal studies with an extended time frame as well as analytical, in vitro and in silico studies on genetically modified (GM) maize in order to comparatively evaluate their use in GM plant risk assessment. In the present study, the results of a 1-year feeding trial with a GM maize MON810 variety, its near-isogenic non-GM comparator and an additional conventional maize variety are presented. The feeding trials were performed by taking into account the guidance for such studies published by the EFSA Scientific Committee in 2011 and the OECD Test Guideline 452. The results obtained show that the MON810 maize at a level of up to 33 % in the diet did not induce adverse effects in male and female Wistar Han RCC rats after a chronic exposure.Electronic supplementary materialThe online version of this article (doi:10.1007/s00204-016-1798-4) contains supplementary material, which is available to authorized users.

show abstract

Yolk Sac Carcinoma, Rat

Cited by 10 publications

References 17 publications

A case report of a metastatic yolk sac carcinoma in the pulmonary artery of a young female Sprague-Dawley rat

A case report of a metastatic yolk sac carcinoma in the pulmonary artery of a young female Sprague-Dawley rat

Diagnostic Exercise

One-year oral toxicity study on a genetically modified maize MON810 variety in Wistar Han RCC rats (EU 7th Framework Programme project GRACE)

Contact Info

Product

Resources

About