Yolk Sac Carcinoma: History of the Concept and the Experimental Models

Damjanov, Ivan; Damjanov, Andrea; Wewer, Ulla M.

doi:10.1007/978-3-642-77852-0_11

Cited by 1 publication

(2 citation statements)

References 67 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The concepts that led to their identification tell a fascinating story, often reminiscent of a detective tale with an abundance of red herrings, due to their occurrence in different sites, their varied histology and the interpretation of the relationships between experimental and human pathology. 1 Their many faces and origins give them a special protean * character. As mentioned in a recent review, 2 these tumours are amongst the privileged few to have an entire monograph devoted to them.…”

Section: Yolk Sac Tumours Revisited a Review Of Their Many Faces Andmentioning

confidence: 99%

“…Yolk sac tumours (YSTs) are intriguing neoplasms; possibly few tumours have been known by more ambiguous names in recent history. The concepts that led to their identification tell a fascinating story, often reminiscent of a detective tale with an abundance of red herrings , due to their occurrence in different sites, their varied histology and the interpretation of the relationships between experimental and human pathology 1 . Their many faces and origins give them a special protean * character.…”

mentioning

confidence: 99%

See 1 more Smart Citation

Yolk sac tumours revisited. A review of their many faces and names

2011

View full text Add to dashboard Cite

We review the current knowledge on human yolk sac tumours (YSTs) 50 years after their initial description. Their complex nomenclature and histogenesis stress the fact that they are not a discrete entity, but represent a multifaceted group of neoplasms, for which the term primitive endodermal tumours would be more appropriate, accounting for their capacity to differentiate into various extraembryonal and somatic cell types. Different histological patterns of human YSTs correlate with the developmental potential of primitive endoderm and mesenchyme, but they are also similar to some murine experimental tumours. Exceptionally, YSTs replicate the tubular structures of the human yolk sac and allantois. Endodermal somatic differentiation reproduces pulmonary, intestinal and hepatic tissues and are identical with some, embryonal-type endodermal, gastric and lung carcinomas, which are indistinguishable from YSTs. YSTs may show an overgrowth of their mesenchymal (sarcomatous) and epithelial components (such as mucinous carcinoma or carcinoid) and also be a source of haematological malignancies. YSTs associated with non-germ cell tumours probably originate from malignant pluripotent somatic stem cells. Only AFP and glypican-3 are characteristic immunohistochemical markers. Pluripotent antibodies (SALL4, Lin28, IMP-3) help in differential diagnoses, while some differentiation markers (CDX2, TTF-1, HepPar1) facilitate recognition of unusual variants of YSTs.

show abstract

Section: Yolk Sac Tumours Revisited a Review Of Their Many Faces Andmentioning

confidence: 99%

mentioning

confidence: 99%