Yohimbine as a treatment for erectile dysfunction: A systematic review and meta-analysis

Wibowo, Dwi Nanda Satriyo Arif; Soebad, Doddy Moesbadianto; Soebadi, Mohammad Ayodhia

doi:10.5152/tud.2021.21206

Cited by 9 publications

(2 citation statements)

References 23 publications

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“…Although initially discovered in plants, a wide range of these compounds have been isolated over decades from marine sources, such as tunicates [ 149 ], sponges [ 150 ], and bryozoans [ 151 ]. βCs display a wide range of outstanding biological activities and, to the best of our knowledge, several plant-isolated and synthetic representative examples, depicted in Figure 47 , have been approved by the FDA and commercialized as drugs at some point, including Taladafil [ 152 ] and Yohimbine [ 153 ] for treating erectile dysfunction, Reserpine [ 154 ], Deserpidine [ 155 ] and Rescinnamine [ 156 ] for treating hypertension, Abecarnil [ 157 ] as an anxiolytic, and Cipargamin [ 158 ] as an antimalarial.…”

Section: Marine Indole Alkaloidsmentioning

confidence: 99%

Current Status of Indole-Derived Marine Natural Products: Synthetic Approaches and Therapeutic Applications

Fernández,

Arnáiz,

Rufo

et al. 2024

Marine Drugs

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Indole is a versatile pharmacophore widely distributed in bioactive natural products. This privileged scaffold has been found in a variety of molecules isolated from marine organisms such as algae and sponges. Among these, indole alkaloids represent one of the biggest, most promising family of compounds, having shown a wide range of pharmacological properties including anti-inflammatory, antiviral, and anticancer activities. The aim of this review is to show the current scenario of marine indole alkaloid derivatives, covering not only the most common chemical structures but also their promising therapeutic applications as well as the new general synthetic routes developed during the last years.

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Section: Marine Indole Alkaloidsmentioning

confidence: 99%

Current Status of Indole-Derived Marine Natural Products: Synthetic Approaches and Therapeutic Applications

Fernández,

Arnáiz,

Rufo

et al. 2024

Marine Drugs

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“…Yohimbine is an alpha-2 adrenergic receptor antagonist that enhances the release of norepinephrine from adrenergic nerves, stimulating erectile function. It can be administered as an oral tablet [ 87 ], improving erectile function and sexual satisfaction in HF patients, but it has some side effects such as anxiety, hypertension, and tachycardia [ 88 ].…”

Section: Therapeutic Management Of Ed In Hfmentioning

confidence: 99%

Heart Failure and Erectile Dysfunction: a Review of the Current Evidence and Clinical Implications

Carella,

Forleo,

Stanca

et al. 2023

Curr Heart Fail Rep

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Purpose of Review Heart failure (HF) and erectile dysfunction (ED) are two common conditions that affect millions of men worldwide and impair their quality of life. ED is a frequent complication of HF, as well as a possible predictor of cardiovascular events and mortality. ED deserves more attention from clinicians and researchers. Recent Findings The pathophysiology of ED in HF involves multiple factors, such as endothelial dysfunction, reduced cardiac output, neurohormonal activation, autonomic imbalance, oxidative stress, inflammation, and drug side effects. The diagnosis of ED in HF patients should be based on validated questionnaires or objective tests, as part of the routine cardiovascular risk assessment. The therapeutic management of ED in HF patients should be individualized and multidisciplinary, considering the patient’s preferences, expectations, comorbidities, and potential drug interactions. The first-line pharmacological treatment for ED in HF patients with mild to moderate symptoms (NYHA class I–II) is phosphodiesterase type 5 inhibitors (PDE5Is), which improve both sexual function and cardiopulmonary parameters. PDE5Is are contraindicated in patients who use nitrates or nitric oxide donors for angina relief, and these patients should be advised to avoid sexual activity or to use alternative treatments for ED. Non-pharmacological treatments for ED, such as psychotherapy or couples therapy, should also be considered if there are significant psychosocial factors affecting the patient’s sexual function or relationship. Summary This review aims to summarize the most recent evidence regarding the prevalence of ED, the pathophysiology of this condition with an exhaustive analysis of factors involved in ED development in HF patients, a thorough discussion on diagnosis and management of ED in HF patients, providing practical recommendations for clinicians.

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Pd‐Monothiosquaramides: Efficient Catalysts for the Enantioselective Imine Reduction of Dihydro‐β‐Carbolines

Reis,

Sathish,

Villaseñor

et al. 2024

Asian J Org Chem

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An efficient enantioselective synthesis of tetrahydro‐β‐carbolines (THBCs) using chiral metal‐monothiosquaramides (M‐MTSQs) was planned. The in situ generated Pd/Fe‐monothiosquaramides (Pd/Fe‐MTSQs) catalysed imine reduction of dihydro‐β‐carbolines exceptionally to afford chiral THBCs with an excellent enantiomeric excess (up to 98% ee). In a catalysis study, Pd‐MTSQ 12a (10 mol%) was found to be more efficient than Pd‐MTSQ 12b and Fe‐MTSQs (13a and 13b) for enantioselective imine reduction of DHBCs 14a‐e. All the major chiral alkyl‐THBC isomers 15a‐c (90% ee, 98% ee and 95% ee, respectively) were observed with R configuration which was explained by Si face hydride attack on alkyl DHBC imines (14a‐c). Surprisingly, S configuration was perceived for the major isomers of chiral aryl‐THBCs 15d and 15e (95% ee and 96% ee, respectively) which was rationalized by Re face hydride attack on aryl DHBC imines (14d and14e).

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Yohimbine as a treatment for erectile dysfunction: A systematic review and meta-analysis

Cited by 9 publications

References 23 publications

Current Status of Indole-Derived Marine Natural Products: Synthetic Approaches and Therapeutic Applications

Current Status of Indole-Derived Marine Natural Products: Synthetic Approaches and Therapeutic Applications

Heart Failure and Erectile Dysfunction: a Review of the Current Evidence and Clinical Implications

Pd‐Monothiosquaramides: Efficient Catalysts for the Enantioselective Imine Reduction of Dihydro‐β‐Carbolines

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