Yogurt consumption and risk of conventional and serrated precursors of colorectal cancer

Zheng, Xiaobin; Wu, Kana; Song, Mingyang; Ogino, Shuji; Fuchs, Charles S.; Chan, Andrew T.; Giovannucci, Edward; Cao, Yin; Zhang, Xuehong

doi:10.1136/gutjnl-2019-318374

Cited by 26 publications

(26 citation statements)

References 8 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The observed relationships were modest and limited to large or advanced adenomas. One recent report from two large US cohort studies found an inverse association only among men who consumed yogurt and risk of AP, but no associations were found for SP risk or for polyp risk among women (53) . Instead, we found a possible weak association with overall AP odds in the Biofilm Study and a significant association with AP odds among women and a strong association with HP in the TCPS.…”

Section: Discussionmentioning

confidence: 94%

“…Instead, we found a possible weak association with overall AP odds in the Biofilm Study and a significant association with AP odds among women and a strong association with HP in the TCPS. The heterogeneity in the design of these studies may contribute to the differences including variation in exposure definition (several assessed broader categories including fermented dairy products) (38)(39)(40)(41)(42)(43) , extreme heterogeneity of available probiotics and yogurt products (including both the types and quantities of lactic acid-producing bacteria strains contained in each), the underlying population and diet and analytic methods including controlling for confounders (42,(44)(45)(46)(47)(48)(49)(50)(51)(52)(53) . Another possible explanation for the inconsistent findings may be misclassification of polyp status in many of the previous studies given the recent understanding of enhanced risk with SSP.…”

Section: Discussionmentioning

confidence: 99%

“…Fewer studies evaluated the association between yogurt intake and risk of colorectal AP (42,45,51,52) . None has evaluated SSP, recently recognised with the potential for malignant transformation (4) , although a recent cohort study found a null association among all serrated polyps, evaluating hyperplastic polyp (HP) and SSP as one entity (53) . Furthermore, just one small randomised controlled trial performed in Japanese population with prior colorectal tumours evaluated the association between probiotic supplement use and risk of colorectal tumours (adenomas and early CRC), but not SSP.…”

mentioning

confidence: 99%

See 2 more Smart Citations

Yogurt consumption and colorectal polyps

et al. 2020

View full text Add to dashboard Cite

Diet modifies the risk of colorectal cancer (CRC), and inconclusive evidence suggests that yogurt may protect against CRC. We analysed the data collected from two separate colonoscopy-based case–control studies. The Tennessee Colorectal Polyp Study (TCPS) and Johns Hopkins Biofilm Study included 5446 and 1061 participants, respectively, diagnosed with hyperplastic polyp (HP), sessile serrated polyp, adenomatous polyp (AP) or without any polyps. Multinomial logistic regression models were used to derive OR and 95 % CI to evaluate comparisons between cases and polyp-free controls and case–case comparisons between different polyp types. We evaluated the association between frequency of yogurt intake and probiotic use with the diagnosis of colorectal polyps. In the TCPS, daily yogurt intake v. no/rare intake was associated with decreased odds of HP (OR 0·54; 95 % CI 0·31, 0·95) and weekly yogurt intake was associated with decreased odds of AP among women (OR 0·73; 95 % CI 0·55, 0·98). In the Biofilm Study, both weekly yogurt intake and probiotic use were associated with a non-significant reduction in odds of overall AP (OR 0·75; 95 % CI 0·54, 1·04) and (OR 0·72; 95 % CI 0·49, 1·06) in comparison with no use, respectively. In summary, yogurt intake may be associated with decreased odds of HP and AP and probiotic use may be associated with decreased odds of AP. Further prospective studies are needed to verify these associations.

show abstract

Section: Discussionmentioning

confidence: 94%

Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

See 1 more Smart Citation

Yogurt consumption and colorectal polyps

et al. 2020

View full text Add to dashboard Cite

show abstract

“…We read with great interest the recent work by Zheng et al published in the Gut journal titled ‘Yogurt consumption and risk of conventional and serrated precursors of colorectal cancer’ 1. This impressive result was widely reported and rapidly disseminated and attracted great public health attention.…”

mentioning

confidence: 94%

Cautious view on the link between yoghurt consumption and risk of colorectal cancer

Ren¹,

Yao

2019

Gut

View full text Add to dashboard Cite

“…Supplementation of Lactobacillus casei has been reported to enhance anti-tumor immunity in colon cancer model by promoting potent Th1 immune responses, activity of CD8 + T and NK cells in ltration in the tumor tissue [11]. Moreover, several cohort studies indicated that probiotics such as Bi dobacterium and Lactobacillus produced from longterm dietary ber and yogurt contributed to cancer prevention and treatment [12,13].…”

Section: Introductionmentioning

confidence: 99%

Immunological Anti-Tumor Activity of Icariside I by Regulating Gut Microbiota and Its Derived Metabolites in a Melanoma Mouse Model

Chen

Cao

Shi

et al. 2020

Preprint

View full text Add to dashboard Cite

Background Emerging evidence has shown that gut microbiome plays important roles in antitumor immunotherapy by shaping systemic immune responses. Specifically, Lactobacillus spp. and Bifidobacterium spp. were previously reported to enhance host immunity and inhibit tumor growth. Furthermore, microbiota-derived metabolites such as short-chain fatty acids (SCFAs) and indole derivatives are gradually regarded as immunomodulatory molecules involved in metabolic signaling pathways. Methods A B16F10 melanoma model was selected as a tumor-bearing animal for the investigation of immunological anti-tumor activity of Icariside I. Gut microbiota structure and composition in cecal content of mice was firstly analyzed by 16S rRNA gene sequence with the goal of screening those bacteria highly associated with tumor immunotherapy. Subsequently, targeted metabolomics approach was employed to quantitatively determine microbiota-derived metabolites such as SCFAs and indole derivatives. The population of multiple lymphocyte subsets in peripheral blood were measured with flowcytometry to evaluate changes of host immunity. Results Icariside I significantly inhibited B16F10 melanoma growth in vivo through regulation of gut microbiota and host immune. Oral administration of icariside I improved the altered gut microbiota community with marked restoration of Lactobacillus spp. and Bifidobacterium spp. abundance. Icariside I was also able to improve the levels of microbiota-derived metabolites such as short-chain fatty acids (SCFAs) and indole derivatives, consequently repairing intestinal barrier and systemic inflammation of tumor-bearing mice. Furthermore, icariside I up-regulated multiple lymphocyte subsets including CD4 + and CD8 + T cells or NK and NKT cells in peripheral blood. Conclusions These results suggested that icariside I may be developed as a novel and natural anticancer adjuvant via microbiome remodeling and host immune regulation.

show abstract

Yogurt consumption and risk of conventional and serrated precursors of colorectal cancer

Abstract: Contributors XiZ, YC and XuZ had full access to all the data in the study and took responsibility for the integrity of the data and the accuracy of the data analysis. Study concept and design: XiZ, YC, XuZ.

Cited by 26 publications

References 8 publications

Yogurt consumption and colorectal polyps

Yogurt consumption and colorectal polyps

Cautious view on the link between yoghurt consumption and risk of colorectal cancer

Immunological Anti-Tumor Activity of Icariside I by Regulating Gut Microbiota and Its Derived Metabolites in a Melanoma Mouse Model

Contact Info

Product

Resources

About