Yogurt and green tea regimen in the preventions of heart disease and cancer in men

Meng, Xianjun; Chen, Zhenlang; Cui, Liang; Wang, Zhixue; Liu, Qiuyun

doi:10.1177/2047487318800769

Cited by 4 publications

(3 citation statements)

References 9 publications

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“…A calcium supplement can reduce risks for most types of cancers . Yogurt harbors lactic-acid-producing bacteria and has demonstrated anticancer properties regardless of cancer types in virtually all epidemiological studies as far as we know …”

Section: Emerging Theory Of Alzheimer’s Disease and Dementia: Biochem...mentioning

confidence: 99%

“…39 Yogurt harbors lacticacid-producing bacteria and has demonstrated anticancer properties regardless of cancer types in virtually all epidemiological studies as far as we know. 40 Most of the theories in the aforementioned field have been published by our laboratory, and the antagonism of oxalate by ethanol and acetate has been verified via flow-cytometry experiments. 33 The hypotheses also account for the inverse association of AD and cancer.…”

Section: And Dementia: Biochemical Balancing Between Proton Stress An...mentioning

confidence: 99%

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Epigenetic Modifications and Neurodegenerative Disorders: A Biochemical Perspective

Zhang

Wang

et al. 2022

ACS Chem. Neurosci.

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Methylations in living cells are methyl groups attached to amino acids, DNA, RNA, and so on. However, their biochemical roles have not been fully defined. A theory has been postulated that methylation leads to hyperconjugation, and the electron-donating feature weakens a nearby chemical bond, which increases the bond length of C 4 −N 4 of 5-methylcytosine, therefore weakening the C 4 −N 4 bond and resulting in stronger protonation or hydrogen bonding of the N 4 nitrogen atom. Protonation can give rise to the generation of mutagenic and carcinogenic strong acids such as HCl, which are also capable of solubilizing stressful, insoluble, and stiff salts. Insoluble and rigid salts such as calcium oxalate and/or calcium phosphate were recently proposed as a primary cause of some neurodegenerative disorders. Protonation of nitrogen atoms in 5-methylcytosine enhances the interaction with negatively charged phosphate groups and contributes to the formation of compact heterochromatin. The electronegativity of the oxygen atoms in the modifications of 5-hydroxymethylcytosine or 5-formylcytosine can shorten the lengths of adjacent bonds with no increase of cation affinity in N 4 . The carboxyl group in 5-carboxylcytosine is a weak acid capable of antagonizing mutagenic HCl and modestly helping solubilize insoluble salts. Electron delocalization of the methyl group in N4methylcytosine results in a lower affinity of N 4 to cations. The positive charge at N 3 in the resonance structure of 3-methylcytosine is lessened by the electron-donating attribute of the methyl group attached to the N 3 atom, consequently reducing acid formation. The electron delocalization of three methyl groups decreases the positive charge in the amino nitrogen in the side group of lysine 4 in histone H3, weakening interactions with phosphate groups and consequently activating gene expression. The carbonyl oxygen in 8oxo-7,8-dihydroguanine draws protons and accumulates HCl, accounting for its moderate mutation propensity and potential capacity to solubilize stiff salts. The biochemical insight will further our understanding on the crosstalk of genetics and epigenetics in the etiology of neurodegenerative diseases.

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Section: Emerging Theory Of Alzheimer’s Disease and Dementia: Biochem...mentioning

confidence: 99%

Section: And Dementia: Biochemical Balancing Between Proton Stress An...mentioning

confidence: 99%

Epigenetic Modifications and Neurodegenerative Disorders: A Biochemical Perspective

Zhang

Wang

et al. 2022

ACS Chem. Neurosci.

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“…5,6 As far as we know, nearly all studies pertinent to lactic acid-containing yogurt have demonstrated anticancer efficacies. 7 The Chinese vinegar factories documented few cancer incidences in several decades, since the weak acetic acid can antagonize both HCl and oxalate. [8][9][10][11][12][13] These reports suggest that holding on to a less acidic cell microenvironment can keep tumor in check.…”

Section: Dietary Regimens To Counteract Strong Acidsmentioning

confidence: 99%

Mutagenesis by RNA-containing telomerase holoenzyme complex or R-loops: a missing piece of the puzzle

Zhang¹,

Lin²,

Wang³

et al. 2022

Preprint

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Overexpression of telomerase has been demonstrated to substantially extend the lifespan of mice. However, this treatment has a negative side, namely the increase of cancer risk. Most components of the telomerase holoenzyme complex possess high basic amino acid content, potentially attracting anions and enhancing the formation of mutagenic and carcinogenic HCl. Weak organic acids antagonize strong acids, and thus can raise cellular pH and modify the microenvironment. R-loops are hybrid DNA and RNA structures, and trigger DNA replication stress and genome instability. RNA has one additional hydroxyl oxygen atom on ribose compared with DNA, and single stranded DNA harbors bases free of hydrogen bonding. These two factors can enhance the buildup of protons via hydrogen bonding and the local formation of HCl. Strong acids generated can augment DNA mutagenesis, and enhance DNA excision, repair and formation of double stranded breaks. Neoplasm must be addressed before lifespan extension remedies via telomerase are ready for use.

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Single-stranded DNA generated by high temperature accepts protons and builds up mutagenic and carcinogenic strong acids

et al. 2021

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Yogurt and green tea regimen in the preventions of heart disease and cancer in men

Cited by 4 publications

References 9 publications

Epigenetic Modifications and Neurodegenerative Disorders: A Biochemical Perspective

Epigenetic Modifications and Neurodegenerative Disorders: A Biochemical Perspective

Mutagenesis by RNA-containing telomerase holoenzyme complex or R-loops: a missing piece of the puzzle

Single-stranded DNA generated by high temperature accepts protons and builds up mutagenic and carcinogenic strong acids

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