Yoghurt as a deglutition aid for oral medication: effects on famotidine powder dissolution rate and pharmacokinetics

Gotoh, Yayoi; Tabata, Yoshiyuki; Sugiura, Shinya; Obara, Michiko; Tomita, Takashi; Suzuki, Takeshi

doi:10.1038/s41598-023-29258-9

Cited by 2 publications

(2 citation statements)

References 23 publications

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“…Ilgaz et al [ 29 ] found that in rabbits regardless of thickness level, administration of levetiracetam with thickening agents does not affect the bioavailability of the drug. Gotoh et al [ 30 ] compared the administration of famotidine without food, with yoghurt and with thickener in rats. They found no difference in plasma concentrations in all 3 groups (with levels being taken up to 6 h after administration).…”

Section: Discussionmentioning

confidence: 99%

Modified medication use in dysphagia: the effect of thickener on drug bioavailability—a systematic review

Atkin,

Devaney,

Yoshimatsu

et al. 2024

Eur Geriatr Med

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Introduction Dysphagia is associated with long-term conditions including strokes, dementia, Parkinson’s disease and frailty. Dysphagia affects 30–40% of the population aged over 65 years-old. Adults with dysphagia often experience long-term conditions requiring multiple medications (often > 5) to manage these. The thickening of liquids is a common compensatory strategy in dysphagia management. Studies suggest that immersion in thickened liquids affects medicines’ solubility in vitro. Clinicians and pharmacists are unaware of the pharmacokinetic/therapeutic effects of thickened liquids on oral medicines. We conducted a systematic review of existing literature on thickeners’ effects on drug bioavailability. Methodology We performed a literature search of MEDLINE & EMBASE. Search terms included: dysphagia/thickened diet (EMBASE only)/ bioavailability or absorption of medicines or pharmacokinetics; excluded: NG feeds/animal studies. Studies included: all genders, countries, > 18 years, community and hospital settings. PRISMA guidance was followed. Results Five hundred seventy results were found, and 23 articles identified following the reference list review. Following an abstract and full-text review, 18 were included. Most articles evaluated thickeners on dissolution profiles in-vitro, with a few investigating in-vivo. Most studies were single-centre prospective studies identifying that thickeners generally affect dissolution rates of medications. Few studies assessed bioavailability or used clinical outcomes. Conclusion Dysphagia and polypharmacy are common in older adults, but little is known about the effects of altering liquid viscosity on the therapeutic effect of most medications. Further larger-scale studies are required to evaluate the therapeutic impact of thickener, on a bigger range of medications, factoring in other variables such as type of thickener, viscosity of thickener and duration of immersion.

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Section: Discussionmentioning

confidence: 99%

Modified medication use in dysphagia: the effect of thickener on drug bioavailability—a systematic review

Atkin,

Devaney,

Yoshimatsu

et al. 2024

Eur Geriatr Med

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“…Controlling the immersion time of tablets in thickened solution was found effective to prevent the non-disintegration 353) . Yogurt made with L. cremoris FC was found to be useful as a deglutition aid for tablets 354,355) .…”

Section: Texture Design Of Food For Dysphagiamentioning

confidence: 99%