Yoga reduces inflammatory signaling in fatigued breast cancer survivors: A randomized controlled trial

Bower, Julienne E.; Greendale, Gail A.; Crosswell, Alexandra D.; Garet, Deborah; Sternlieb, Beth; Ganz, Patricia A.; Irwin, Michael R.; Olmstead, Richard G.; Arevalo, Jesusa M.G.; Cole, Steve W.

doi:10.1016/j.psyneuen.2014.01.019

Cited by 222 publications

(243 citation statements)

References 50 publications

(79 reference statements)

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“…The differential expression of OAS2 has been reported in prostate and breast cancers. 41,42 Our study also confirmed the presence of OAS2 in oral tumours at both mRNA and protein levels. The significance of OAS2 in the tumour microenvironment can be appreciated by the observation that certain tumours exist in an antiviral state and hence are resistant to oncolytic-virus-based virotherapy used to obliterate tumour cells.…”

Section: Discussionsupporting

confidence: 81%

Extracellular 2′5′‐oligoadenylate synthetase 2 mediates T‐cell receptor CD3‐ζ chain down‐regulation via caspase‐3 activation in oral cancer

et al. 2015

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SummaryDecreased expression of CD3-f chain, an adaptor protein associated with T-cell signalling, is well documented in patients with oral cancer, but the mechanistic justifications are fragmentary. Previous studies in patients with oral cancer have shown that decreased expression of CD3-f chain was associated with decreased responsiveness of T cells. Tumours are known to induce localized as well as systemic immune suppression. This study provides evidence that oral tumour-derived factors promote immune suppression by down-regulating CD3-f chain expression. 2 0 5 0 -Oligoadenylate synthetase 2 (OAS2) was identified by the proteomic approach and our results established a causative link between CD3-f chain down-regulation and OAS2 stimulation. The surrogate situation was established by over-expressing OAS2 in a HEK293 cell line and cell-free supernatant was collected. These supernatants when incubated with T cells resulted in down-regulation of CD3-f chain, which shows that the secreted OAS2 is capable of regulating CD3-f chain expression. Incubation of T cells with cell-free supernatants of oral tumours or recombinant human OAS2 (rh-OAS2) induced caspase-3 activation, which resulted in CD3-f chain down-regulation. Caspase-3 inhibition/down-regulation using pharmacological inhibitor or small interfering RNA restored down-regulated CD3-f chain expression in T cells induced by cell-free tumour supernatant or rh-OAS2. Collectively these results show that OAS2 leads to impairment in CD3-f chain expression, so offering an explanation that might be applicable to the CD3-f chain deficiency observed in cancer and diverse disease conditions.

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Section: Discussionsupporting

confidence: 81%

Extracellular 2′5′‐oligoadenylate synthetase 2 mediates T‐cell receptor CD3‐ζ chain down‐regulation via caspase‐3 activation in oral cancer

et al. 2015

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“…These findings demonstrate a causal effect of prosocial behavior on leukocyte gene regulation, and they contribute to a growing body of literature mapping the molecular pathways that may link prosocial behavior to physical health. These findings also add purposeful engagement in prosocial behavior to the small list of other interventions that have previously been found to reduce CTRA gene expression (e.g., meditation, yoga, and cognitivebehavioral stress management; Antoni et al, 2012;Black et al, 2013;Bower et al, 2014;Creswell et al, 2012;Irwin et al, 2014).…”

Section: Discussionmentioning

confidence: 60%

Kindness in the blood: A randomized controlled trial of the gene regulatory impact of prosocial behavior

Nelson‐Coffey

Fritz

Lyubomirsky

et al. 2017

Psychoneuroendocrinology

Self Cite

105

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A B S T R A C TContext: Prosocial behavior is linked to longevity, but few studies have experimentally manipulated prosocial behavior to identify the causal mechanisms underlying this association. One possible mediating pathway involves changes in gene expression that may subsequently influence disease development or resistance. Design, setting, participants: In the current study, we examined changes in a leukocyte gene expression profile known as the Conserved Transcriptional Response to Adversity (CTRA) in 159 adults who were randomly assigned for 4 weeks to engage in prosocial behavior directed towards specific others, prosocial behavior directed towards the world in general, self-focused kindness, or a neutral control task. Results: Those randomized to prosocial behavior towards specific others demonstrated improvements (i.e., reductions) in leukocyte expression of CTRA indicator genes. No significant changes in CTRA gene expression were observed in the other 3 conditions. Conclusion: These findings suggest that prosocial behavior can causally impact leukocyte gene expression profiles in ways that might potentially help explain the previously observed health advantages associated with social ties.

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“…Eight trials (n ¼ 478), reported in nine papers, were included in the review (15,16,(23)(24)(25)(26)(27)(28)(29). The results of the search and the reasons for exclusions are presented in Fig.…”

Section: Resultsmentioning

confidence: 99%

“…Six trials provided data about TNFa (15,16,23,24,27,28). Again a significant beneficial effect was observed, with a WMD of À0.64 pg/mL (95% CI, À1.21 to À0.06), as shown in Supplementary Fig.…”

Section: Effect Estimates Of Exercise On the Inflammatory Mediatorsmentioning

confidence: 90%

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The Effect of Exercise Training on Mediators of Inflammation in Breast Cancer Survivors: A Systematic Review with Meta-analysis

Meneses-Echávez

Correa-Bautista

González‐Jiménez

et al. 2016

Cancer Epidemiology, Biomarkers &Amp; Prevention

120

104

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Several sources of evidence indicate that exercise during and after breast cancer could positively modulate the tumor microenvironment. This meta-analysis aimed to determine the effects of exercise training on mediators of inflammation in breast cancer survivors. We searched for randomized controlled trials published from January 1990 to March 2014. An inverse variance method of meta-analysis was performed using a random effects model in the presence of statistical heterogeneity. Eight high-quality trials (n ¼ 478) were included. Exercise improved the serum concentrations of IL6 [weighted mean difference (WMD) ¼ À0.55 pg/mL; 95% confidence interval (CI), À1.02 to À0.09], TNFa (WMD ¼ À0.64 pg/mL; 95% CI, À1.21 to À0.06), IL8 (MD ¼ À0.49 pg/mL; 95% CI, À0.89 to À0.09), and IL2 (WMD ¼ 1.03 pg/mL; 95% CI, 0.40 to 1.67). No significant differences were found in the serum concentrations of C-reactive protein (WMD ¼ À0.15; 95% CI, À0.56 to 0.25) or IL10 (WMD ¼ 0.41; 95% CI, À0.18 to 1.02). Exercise training positively modulates chronic low-grade inflammation in women with breast cancer, which may impact upon carcinogenic mechanisms and the tumor microenvironment. These findings align with the other positive effects of exercise for breast cancer survivors, reinforcing the appropriateness of exercise prescription in this population.

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Yoga reduces inflammatory signaling in fatigued breast cancer survivors: A randomized controlled trial

Cited by 222 publications

References 50 publications

Extracellular 2′5′‐oligoadenylate synthetase 2 mediates T‐cell receptor CD3‐ζ chain down‐regulation via caspase‐3 activation in oral cancer

Extracellular 2′5′‐oligoadenylate synthetase 2 mediates T‐cell receptor CD3‐ζ chain down‐regulation via caspase‐3 activation in oral cancer

Kindness in the blood: A randomized controlled trial of the gene regulatory impact of prosocial behavior

The Effect of Exercise Training on Mediators of Inflammation in Breast Cancer Survivors: A Systematic Review with Meta-analysis

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