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Reaction of Substituted Furan-2-carboxaldehydes and Furo[b]pyrrole Type Aldehydes with Hippuric Acid

“…The condensation products of aldehydes 1a-3b with hippuric acid catalysed by potassium acetate [18] were prepared in dry acetic anhydride as shown in Schemes 2-4. The condensations of 1a-e were also performed under microwave conditions, reducing the reaction times while affording yields comparable to those achieved in the reactions carried out under "classical" conditions (Table 1).…”

“…We also wished to compare the "classical" method with the effect of microwave irradiation and to find conditions to increase the yield or the rate of condensations. Microwave irradiation is an unconventional method of chemical reaction activation indicated to be suitable for use in reactions of thermolabile compounds because it shortens the exposure of the reaction mixtures to high temperatures [15][16][17][18].…”

Reactions of Substituted Furan-2-carboxaldehydes and Furo[b]pyrrole Type Aldehydes with Benzothiazolium Salts

“…The chemical shifts of protons were assigned using gs-H,H-COSY (gradient selected Correlated Spectroscopy) measurements which provided the proton-proton connectivity. 13 C-NMR chemical shift assignments were straightforward using gs-HSQC (gradient selected Heteronuclear Quantum Coherence) and gs-HMBC (gradient selected Heteronuclear Multiple Bond Correlation). …”

“…Their full synthesis and properties were described recently [11]. Only a few condensation products of furo [b]pyrrole type aldehydes have been described [12,13]. We have recently published in this journal the results of the study of the reactions of substituted furan-2-carboxaldehydes and furo [b]pyrrole type aldehydes with hippuric acid [14].…”

Effect of microwave irradiation on reactions of 5-arylfuran-2-carboxaldehydes with some active methylene compounds

“…[1][2][3][4] The microwave-induced activation and acceleration of various reactions has several advantages and is suitable for use with polar and thermolabile compounds. 5 The high irradiating efficiency in a short time gives rise to remarkable rate enhancement.…”