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Bharti, Neelam; Shailendra,; Coles, Simon J.; Hursthouse, Michael B.; Mayer, Thomas; Garza, Manuel; Cruz-Vega, Delia Elva; Mata-Cárdenas, Benito David; Naqvi, Fehmida; Maurya, Mannar R.; Peerzada, Mudasir Nabi

doi:10.1002/1522-2675(200209)85:9<2704::aid-hlca2704>3.0.co;2-x

Cited by 29 publications

(18 citation statements)

References 12 publications

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“…These compounds possess a wide range of biological activities which vary when the structure of the complex is slightly changed by the introduction or removal of different functional groups [1][2][3][4][5][6][7][8][9].…”

Section: Introductionmentioning

confidence: 99%

Synthesis, characterization and biological activities of 3-methylbenzyl 2-(6-methyl pyridin-2-ylmethylene)hydrazine carbodithioate and its transition metal complexes

Ravoof

Crouse

Tahir

et al. 2010

Transition Met Chem

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A tridentate nitrogen-sulfur Schiff base, 3-methylbenzyl 2-(6-methylpyridin-2-ylmethylene)hydrazine carbodithioate (6mpyS3M), was synthesized by condensation of 6-methylpyridine-2-aldehyde with S-3-methylbenzyldithiocarbazate. It crystallized in space group P 2 1 /n. It displayed intermolecular N-HÁÁÁN hydrogen bonding between the a-nitrogen and the pyridyl nitrogen. The thione sulfur is in a trans position with respect to the 6-methylpyridine fragment across the C-N bond but adopts a cis position with the 3-methylbenzyl fragment through the C-S bond. Octahedral complexes containing two 6mpyS3M ligands were prepared with Cu(II), Ni(II), Zn(II) and Cd(II). 6mpyS3M and its metal complexes were assayed against selected microbes and two breast cancer cell lines. 6mpyS3M was strongly active against both cancer cell lines. Its metal complexes showed high selectivity with Cu(II), Ni(II) and Zn(II) complexes strongly active against only one of the cancer cell lines, whereas the Cd(II) complex was strongly active only against the other. Only Cu(II) and Cd(II) complexes were active against some of the bacteria.

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Section: Introductionmentioning

confidence: 99%

Synthesis, characterization and biological activities of 3-methylbenzyl 2-(6-methyl pyridin-2-ylmethylene)hydrazine carbodithioate and its transition metal complexes

Ravoof

Crouse

Tahir

et al. 2010

Transition Met Chem

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“…Estes estudos servem de modelos para trabalhos posteriores indicando que a coordenação deste fármaco e seus derivados deve ser alvo de investigação. 105 …”

Section: Figura 5 Estrutura Proposta Para O Complexo De Pd(ii) Com Cunclassified

Coordenação de metais a antibióticos como uma estratégia de combate à resistência bacteriana

Rocha¹,

Pinto²,

Ruggiero³

et al. 2011

Quím. Nova

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Recebido em 12/1/10; aceito em 2/8/10; publicado na web em 16/11/10 COORDINATION OF METALS TO ANTIBIOTICS AS A STRATEGY TO COMBAT BACTERIAL RESISTANCE. Antibiotic resistance has been growing at an alarming rate and consequently the arsenal of effective antibiotics against Gram-negative and Gram-positive bacteria has dropped dramatically. In this sense there is a strong need to produce new substances that not only have good spectrum of activity, but having new mechanisms of action. In this regard, this paper emphasizes the coordination of metals to antibiotics as a strategy for reversing antibiotic resistance and production of new drugs, with a special focus on quinolones, fluoroquinolones, sulfonamides and tetracyclines.Keywords: antibiotics; metal-based drugs; bacterial resistance. INTRODUÇÃOA descoberta dos antibióticos representa um dos mais importantes marcos da medicina moderna. A introdução das sulfonamidas em 1930 e da penicilina na década posterior provocaram um grande avanço no tratamento de doenças infecciosas, causando uma drásti-ca diminuição nas taxas de mortalidade e uma enorme sensação de bem-estar. 1 O sucesso dos primeiros antibióticos na cura de doenças até então consideradas letais acarretou uma intensa busca por novas drogas. De fato, as décadas de 40, 50 e 60 do século passado foram marcadas pela imensa quantidade de antibióticos produzidos e rapidamente incorporados às práticas clínicas. 2 No entanto, nas décadas posteriores houve um declínio na produção destes compostos. Entre o lançamento das quinolonas em 1962 até a aprovação das oxazolidinonas em 2000, houve pouca inovação no que se refere à introdução de novas classes de antibióticos de uso clínico bem-sucedido. 2 Quando um antibiótico é descoberto e introduzido no mercado, sua utilidade clínica começa a diminuir até um ponto em que há um aumento na restrição de seu uso. Esta restrição é provocada pelo surgimento de cepas resistentes. As bactérias surgiram na terra há bilhões de anos e para sobreviver desenvolveram mecanismos de resistência aos antibióticos que são encontrados livres na natureza. 3 Portanto, não é surpreendente o fato de que muitos antibióticos lançados nas últimas décadas, que são em sua ampla maioria de origem natural ou semissintética, terem utilidade limitada na época de sua descoberta e em pouco tempo se tornarem obsoletos. 3 Outro fator que contribui muito para tornar um antibiótico menos eficiente é a sua utilização indiscriminada e incorreta, o que vem a favorecer o surgimento de micro-organismos resistentes. Atualmente, algumas classes de micro-organismos representam extrema preocupação para a saúde publica. Dentre os que mais provocam mortes no mundo estão o Staphylococcus aureus meticilina-resistente (MRSA), Staphylococcus aureus vancomicina-resistente (VRSA), Escherichia coli, Klebsiella pneumoniae e Pseudomonas aeruginosa, que são bactérias resistentes a múltiplas drogas. Os processos infecciosos causados por estas classes de micro-organismos geralmente estão associados com alta letalidade e altos custos d...

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“…The Schiff base moiety is potentially ambidenate and can coordinate through nitrogen with either oxygen or sulfur atoms. The vast literature on structural studies of Schiff-base complexes reveals some interesting features of their coordination behavior [1][2][3][4][5][6][7][8].…”

Section: Introductionmentioning

confidence: 99%

Synthesis, spectroscopic characterization, and 3D molecular modeling of lead(II) complexes of unsymmetrical tetradentate Schiff-base ligands

Singh

2011

Res Chem Intermed

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Solid complexes of Pb(II) with unsymmetrical Schiff-base ligands (H 2 L) derived from 2-aminobenzophenone, thiosemicarbazide, semicarbazide, salicylaldehyde, 2-hydroxynaphthaldehyde, and o-hydroxyacetophenone have been synthesized and characterized by elemental analysis, conductance measurements, molecular weight measurement, and UV-Vis, FTIR, 1 H NMR, and 13 C NMR spectroscopy. The spectral studies suggest the ligands behave as dibasic tetradentate ligands with ONNO/ONNS donor atom sequences toward the central metal ion. From the microanalytical data, the stoichiometry of the complexes was found to be 1:1 (metal:ligand). The physicochemical data suggest a tetracoordinated environment around the metal ion. Three-dimensional molecular modeling and analysis of bond lengths and bond angles have also been conducted for a representative compound, [PbL 1 ], to substantiate the proposed structures.

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Cited by 29 publications

References 12 publications

Synthesis, characterization and biological activities of 3-methylbenzyl 2-(6-methyl pyridin-2-ylmethylene)hydrazine carbodithioate and its transition metal complexes

Synthesis, characterization and biological activities of 3-methylbenzyl 2-(6-methyl pyridin-2-ylmethylene)hydrazine carbodithioate and its transition metal complexes

Coordenação de metais a antibióticos como uma estratégia de combate à resistência bacteriana

Synthesis, spectroscopic characterization, and 3D molecular modeling of lead(II) complexes of unsymmetrical tetradentate Schiff-base ligands

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