Yijinjing Qigong intervention shows strong evidence on clinical effectiveness and electroencephalography signal features for early poststroke depression: A randomized, controlled trial

Abstract

ObjectiveAlthough Traditional Chinese Yijinjing Qigong Exercise (YJJQE) as mind–body intervention is popularly used among adults to ameliorate depressive symptoms in China, no randomized controlled trials (RCTs) are available to evaluate the effects of YJJQE in patients with poststroke depression (PSD). This study aims to explore the clinical efficacy and the neurological and psychiatric mechanism in brain network functional connectivity underlying electroencephalography (EEG).Materials and methodsA total of 60 patients, diagnosed with mild PSD, were randomly (1:1) assigned to YJJQE group (n = 30) and control group of routine segmental rehabilitation training group (n = 30) for a 60-min exercise session once a day for 3 weeks. All outcome measures were collected at baseline and 3-weeks ending intervention. The primary outcome was the 24-item Hamilton Depression Scale (HAMD-24) score, evaluation at more time points for 1 month of follow-up. The secondary outcomes were EEG data in four frequency domains (δ, θ, α, and β), global efficiency (GE), local efficiency (LE), GE/LE curve [areas under the curve (AUC)], Phase Lag Index (PLI), (HAMD-24) Score and EEG correlation analysis.ResultsAll patients showed no significant differences in baseline data. After 3 weeks and 1 month of follow-up, the YJJQE group demonstrated significant decreasing changes compared to the control group on the HAMD-24 scores (p < 0.001). Furthermore, the YJJQE group also showed a significant reduction in θ wave, and an increase in both GE and LE. Compared to the control group, the YJJQE Qigong group showed significantly greater functional connectivity in the δ, θ, and β frequency bands in the brain network of the degree of phase synchronization (p < 0.001). HAMD-24 Score and EEG correlation analysis negative correlation in the Qigong group θ wave (p < 0.001).ConclusionOur findings demonstrated that YJJQE is estimated to effectively alleviate the depressed mood of patients with PSD by promoting the efficiency in information transmission of network functional connectivity and its integration ability in different brain regions. Therefore, the YJJQE would be useful as a non-pharmacological treatment to prevent PSD.Clinical trial registration[http://www.chictr.org.cn/showproj.aspx?proj=55789], identifier [ChiCTR2000035588].

Exercise training-attenuated insulin resistance and liver injury in elderly pre-diabetic patients correlates with NLRP3 inflammasome

“…With simple patterns and directions, and moderate-intensity, safety, and efficacy, Yijinjing is easy to practice and is especially favored by the elderly populations. Previous studies showed that Yijinjing had the potential to improve cognitive function in patients with chronic schizophrenia ( 23 ) and post-stroke ( 24 , 25 ), as well as ameliorate symptoms of people with knee osteoarthritis ( 26 ), ankylosing spondylitis ( 27 ). However, no randomized controlled trials (RCTs) are available to evaluate the effects of Yijinjing in patients with metabolic diseases such as pre-diabetes.…”

Effectiveness of Tuina Therapy Combined With Yijinjing Exercise in the Treatment of Nonspecific Chronic Neck Pain

“…17 The results of a systematic study showed that physical and mental exercises, including yijinjing, are beneficial for the recovery of neck pain and disability. 18 Two recent studies on the neuroimaging of patients with stroke after a yijinjing intervention reported that it can modulate brain neural network connections, which may be a central mechanism of its analgesia. 18,19 Although tuina and yijinjing have been widely used in clinical treatment of NCNP in China, few high-level randomized clinical trials have been performed because of the limitations of traditional Chinese medicine research methods.…”

“… 18 Two recent studies on the neuroimaging of patients with stroke after a yijinjing intervention reported that it can modulate brain neural network connections, which may be a central mechanism of its analgesia. 18 , 19 …”

“…18 Two recent studies on the neuroimaging of patients with stroke after a yijinjing intervention reported that it can modulate brain neural network connections, which may be a central mechanism of its analgesia. 18,19 Although tuina and yijinjing have been widely used in clinical treatment of NCNP in China, few high-level randomized clinical trials have been performed because of the limitations of traditional Chinese medicine research methods. In addition, nondrug therapy integrated into pain management is recommended by a clinical practice guideline.…”

“…It is a moderately intense mind-body exercise that is easy to practice with few limitations . The results of a systematic study showed that physical and mental exercises, including yijinjing, are beneficial for the recovery of neck pain and disability . Two recent studies on the neuroimaging of patients with stroke after a yijinjing intervention reported that it can modulate brain neural network connections, which may be a central mechanism of its analgesia …”