Yields of mesenchymal stromal cells from synovial fluid reflect those from synovium in patients with rheumatoid arthritis

Kohno, Yuji; Mizuno, Mitsuru; Endo, Kentaro; Ozeki, Nobutake; Katano, Harutaka; Matsumoto, M; Kaneko, Haruka; Takazawa, Yuji; Koga, Hideyuki; Sekiya, Ichiro

doi:10.1016/j.tice.2021.101727

Cited by 4 publications

(5 citation statements)

References 51 publications

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“…The Navier–Stokes equations with the first model of dependent‐viscosity or the shear rate are dependent on fluid concentration in an incompressible synovial fluid model (denoted as a

Model{-}I

) 3,4

\mu (\hat{C},\hat{D})={\mu }_{0}{(1+{\gamma }^{2}{|\hat{D}|}^{2})}^{n(\hat{C})}.

…”

Section: Synovia Modelmentioning

confidence: 99%

“…The Navier-Stokes equations with the first model of dependent-viscosity or the shear rate are dependent on fluid concentration in an incompressible synovial fluid model (denoted as a Model − I). 3,4 μ…”

Section: Synovia Modelmentioning

confidence: 99%

“…In the early era, Synovia or synovial fluid gained more attractiveness among many modelers, engineers, and physicians as it is a vital sign in all human physiques. In addition, Synovia studies are important in some physiological processes, for instance, osteoarthritis biomarkers, 1 solubilization of formic acid applications using a combination of Synovia and plasma, 2 rheumatoid arthritis processes, 3 defect of focal cartilage processes, 4 and knee osteoarthritis in the early stage 5 . Nevertheless, a combination of synovial fluid which is considered a non‐Newtonian fluid, and peristaltic flow have a few studies; Khan et al 6 scrutinized the influences of Magnetohydrodynamics (MHD) in the induced case on peristaltic pumping of nanofluid in an asymmetric channel.…”

Section: Introductionmentioning

confidence: 99%

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Technical computations for dependent shear rate effect on magnetized peristaltic transport of synovia with two fluid viscosity models: Arthritis treatments

et al. 2023

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Synovitis studies are the key to the treatment of most arthritis diseases in a human physique. So this study visualizes the effects of two dependent fluid viscosity models on magnet nano peristaltic transport of synovial fluid in nonuniform channel walls. Two fluid models are constructed, the first model considered that the Shear rate is dependent on fluid concentration (model-I), and the exponentially dependent viscosity on the fluid concentration is proposed as a second model (model-II). The fluid models are represented by a highly nonlinear system of partial differential equations. Joule heat, thermal radiation, and Arrhenius energy are studied as external effects. Those models are offered in a gradient mechanism, then simplified using droppings bars and using the fact of long wavelength, and low Reynolds. Pressure gradient and trapped bolus profiles and shear stress distribution as well as fluid temperature, velocity, and concentration performance are scrutinized. Analytical results are obtained in appropriate/chosen boundary conditions depending on the walls of the channel. Attracted/signified results are compared with the nearest trusted results by Khan et al. Solution intervals are sub-divided and analytically treated at each of them by multi-stage differential

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“…The Navier–Stokes equations with the first model of dependent‐viscosity or the shear rate are dependent on fluid concentration in an incompressible synovial fluid model (denoted as a

Model{-}I

) 3,4

\mu (\hat{C},\hat{D})={\mu }_{0}{(1+{\gamma }^{2}{|\hat{D}|}^{2})}^{n(\hat{C})}.

…”

Section: Synovia Modelmentioning

confidence: 99%

Section: Synovia Modelmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Technical computations for dependent shear rate effect on magnetized peristaltic transport of synovia with two fluid viscosity models: Arthritis treatments

et al. 2023

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“…De Bari et al characterized multipotent MSC from adult human synovium (47). In this context, it has been shown that MSC can be isolated from the synovial fluid of patients with RA (48,49). The precise role of MSC in RA pathology remains unclear.…”

Section: Sf-fls Versus Sf-mesenchymal Stem Cellsmentioning

confidence: 99%

“…SF-MSC are obtained in vitro according to the same protocol used for the SF-FLS culture. After SF culture, SF-MSC are maintained in culture with the plastic-adherent mononuclear cell fraction and can be cultured as fibroblast-like cells (48). Meanwhile, the relationship between the SF-MSC and SF-FLS remains unclear (39).…”

Section: Sf-fls Versus Sf-mesenchymal Stem Cellsmentioning

confidence: 99%

The synovial fluid fibroblast-like synoviocyte: A long-neglected piece in the puzzle of rheumatoid arthritis pathogenesis

Mahmoud

Kaabachi²,

Sassi³

et al. 2022

Front. Immunol.

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Rheumatoid arthritis (RA) is a systemic autoimmune disease during which fibroblast-like synoviocytes (FLS) contribute to both joint inflammation and destruction. FLS represent the core component of the synovial membrane. Following inflammation of this membrane, an effusion of cell-rich synovial fluid (SF) fills the joint cavity. Unlikely, SF has been shown to contain fibroblasts with some shared phenotypic traits with the synovial membrane FLS. These cells are called SF-FLS and their origin is still unclear. They are either brought into the synovium via migration through blood vessels, or they could originate within the synovium and exist in projections of the synovial membrane. SF-FLS function and phenotype are poorly documented compared to recently well-characterized synovial membrane FLS subsets. Furthermore, no study has yet reported a SF-FLS single-cell profiling analysis. This review will discuss the origin and cellular characteristics of SF-FLS in patients with RA. In addition, recent advances on the involvement of SF-FLS in the pathogenesis of RA will be summarized. Current knowledge on possible relationships between SF-FLS and other types of fibroblasts, including synovial membrane FLS, circulating fibrocytes, and pre- inflammatory mesenchymal (PRIME) cells will also be addressed. Finally, recent therapeutic strategies employed to specifically target SF-FLS in RA will be discussed.

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Mesenchymal stem cells in autoimmune disease: A systematic review and meta-analysis of pre-clinical studies

Swain,

Boyce,

Bromet

et al. 2024

Biochimie

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Yields of mesenchymal stromal cells from synovial fluid reflect those from synovium in patients with rheumatoid arthritis

Cited by 4 publications

References 51 publications

Technical computations for dependent shear rate effect on magnetized peristaltic transport of synovia with two fluid viscosity models: Arthritis treatments

Technical computations for dependent shear rate effect on magnetized peristaltic transport of synovia with two fluid viscosity models: Arthritis treatments

The synovial fluid fibroblast-like synoviocyte: A long-neglected piece in the puzzle of rheumatoid arthritis pathogenesis

Mesenchymal stem cells in autoimmune disease: A systematic review and meta-analysis of pre-clinical studies

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