Yield of pleural biopsy in different types of tubercular effusions

Tousheed, Syed Zulkharnain; Ranganatha, Ramanjenaya; Kumar, Hemanth; Sagar, Chandrasekar; Manjunath, P.H.; Philip, Danne S.; Punita, M.; Hibare, Kedar; Reddy, Mallika; Muralimohan, B V

doi:10.1016/j.ijtb.2020.07.023

Cited by 1 publication

(2 citation statements)

References 16 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…All these analyses have limitations. The yield of M. tuberculosis is shown to be very low in tuberculous pleural effusions [11]. AFB staining and cultures from most patients are positive in only 10% of cases [12].…”

Section: Invasive and Microbiological Diagnosis Of Tuberculous Pleurisymentioning

confidence: 95%

“…The problem is that značaj adenozin deaminaze u dijagnostikovanju tuberkuloznog pleuritisa significance of adenosine deaminase in diagnosing tuberculous pleurisy Sve navedene analize imaju ograničenja. Pokazalo se da je količina M. tuberculosis veoma niska u tuberkuloznom pleuritisu [11]. Direktna mikroskopija AARB i kulture su uglavnom pozitivni u svega 10% slučajeva [12].…”

Section: Invasive and Microbiological Diagnosis Of Tuberculous Pleurisyunclassified

See 1 more Smart Citation

Significance of adenosine deaminase in diagnosing tuberculous pleurisy

Janković,

Ilić,

Jandrić

2023

Srpski medicinski časopis Lekarske komore

View full text Add to dashboard Cite

Tuberculous pleurisy (TP) is one of the most common extra-pulmonary tuberculosis forms. Tuberculous pleurisy occurs when Mycobacterium tuberculosis antigen is released from a ruptured caseous focus into the pleural space causing hyperinflammatory response with a rapid influx of lymphocytes. Acid-fast bacilli (AFB) staining, cultures and pathohistological biopsy finding are positive in most patients only in less than 10% of samples. Culture results take about 6-8 weeks which delays the diagnosis. A problem also occurs in the differentiation of effusions with lymphocytic predominance. Adenosine deaminase (ADA) is a biochemical marker with high sensitivity and specificity and is considered a gold standard within biomarkers when it comes to diagnosing TP. Using an algorithm for the values of ADA above or below 40 U/L we can distinguish this type of effusion from other types. ADA in pleural punctate is a fast, efficient, and economical way for clarifying the etiology of a pleural effusion such as tuberculous pleurisy and treatment response during the follow up period.

show abstract

Section: Invasive and Microbiological Diagnosis Of Tuberculous Pleurisymentioning

confidence: 95%

Section: Invasive and Microbiological Diagnosis Of Tuberculous Pleurisyunclassified