Yidu-toxicity blocking lung decoction ameliorates inflammation in severe pneumonia of SARS-COV-2 patients with Yidu-toxicity blocking lung syndrome by eliminating IL-6 and TNF-a

Zhao, Jie; Yang, Xiaodong; Wang, Chenghua; Song, Shuai; Cao, Kun; Wei, Taohua; Ji, Qiaoxue; Zheng, Wanqun; Li, Jiali; Zhou, Xue; Liu, Jie

doi:10.1016/j.biopha.2020.110436

Cited by 28 publications

(44 citation statements)

References 34 publications

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“…Of the 40 eligible RCTs 15 , 16 , 17 , 18 , 19 , 20 , 21 , 22 , 23 , 24 , 25 , 26 , 27 , 28 , 29 , 30 , 31 , 32 , 33 , 34 , 35 , 36 , 37 , 38 , 39 , 40 , 41 , 42 , 43 , 44 , 45 , 46 , 47 , 48 , 49 , 50 , 51 , 52 , 53 , 54 , 18 (45%) were single-center trials and most were conducted in the Asian region (26/40, 65%) and organized by universities (31/40, 78%). 33 (83%) used a structured format for their abstract and same number of studies evaluated pharmacological interventions for the prevention or treatment of COVID-19.…”

Section: Resultsmentioning

confidence: 99%

Abstracts for reports of randomized trials of COVID-19 interventions had low quality and high spin

Wang

Chen

Wang

et al. 2021

Journal of Clinical Epidemiology

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Objectives : To assess the reporting quality of abstracts for published randomized controlled trials (RCTs) of interventions for coronavirus disease 2019 (COVID-19), including the use of spin strategies and the level of spin for RCTs with statistically non-significant primary outcomes, and to explore potential predictors for reporting quality and the severity of spin. Study Design and Setting : PubMed was searched to find RCTs that tested interventions for COVID-19, and the reporting quality and spin in the abstracts were assessed. Linear regression analyses were used to identify potential predictors. Results : Forty RCT abstracts were included in our assessment of reporting quality, and a higher word count in the abstract was significantly correlated with higher reporting scores (95% CI 0.044 to 0.658, P=0.026). Multiple spin strategies were identified. Our multivariate analyses showed that geographical origin was associated with severity of spin, with research from non-Asian regions containing fewer spin strategies (95% CI -0.760 to -0.099, P=0.013). Conclusions : The reporting quality of abstracts of RCTs of interventions for COVID-19 is far from satisfactory. A relatively high proportion of the abstracts contained spin, and the findings reported in the results and conclusion sections of these abstracts need to be interpreted with caution.

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Section: Resultsmentioning

confidence: 99%

Abstracts for reports of randomized trials of COVID-19 interventions had low quality and high spin

Wang

Chen

Wang

et al. 2021

Journal of Clinical Epidemiology

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“…A total of 40 representative clinical trials, including 11 randomized controlled trials (RCTs), 16 retrospective cohort studies (RCSs), 5 multi-center clinical observations, and 8 others were completed and summarized 27 , 28 , 30 , 31 , 32 , 36 , 37 , 38 , 39 , 40 , 41 , 42 , 43 , 44 , 45 , 46 , 47 , 48 , 49 , 50 , 51 , 52 , 53 , 54 , 55 , 56 , 57 , 58 , 59 , 60 , 61 , 62 , 63 , 64 , 65 , 66 , 67 , 68 , 69 , 70 . According to the available clinical data, integrated TCM and WM exhibited several clinical advantages in COVID-19 treatment, including the outcomes of 1) clinical manifestations, 2) lung features, and 3) laboratory findings as shown in Table 1 27 , 28 , 30 , 31 , 32 , 36 , 37 , 38 , 39 , 40 , 41 , 42 , 43 , 44 , 45 , 46 , 47 , 48 , 49 , 50 , 51 , <...>…”

Section: Tcm In the Treatment Of Covid-19mentioning

confidence: 99%

“…According to the available clinical data, integrated TCM and WM exhibited several clinical advantages in COVID-19 treatment, including the outcomes of 1) clinical manifestations, 2) lung features, and 3) laboratory findings as shown in Table 1 27 , 28 , 30 , 31 , 32 , 36 , 37 , 38 , 39 , 40 , 41 , 42 , 43 , 44 , 45 , 46 , 47 , 48 , 49 , 50 , 51 , 52 , 53 , 54 , 55 , 56 , 57 , 58 , 59 , 60 , 61 , 62 , 63 , 64 , 65 , 66 , 67 , 68 , 69 , 70 . Furthermore, based on Table 1 , the clinical evidence of TCM for typical characteristics of COVID-19 were analyzed and summarized in Table 2 27 , 28 , 30 , 31 , 32 , 36 , 37 , 38 , 39 , 40 , 41 , 42 , 43 , 44 , 45 , 46 , 47 , 48 , 49 , 50 , 51...…”

Section: Tcm In the Treatment Of Covid-19mentioning

confidence: 99%

Traditional Chinese medicine in COVID-19

Lyu

Fan

Xiao

et al. 2021

Acta Pharmaceutica Sinica B

148

118

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COVID-19 pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has spread across the globe, posing an enormous threat to public health and safety. Traditional Chinese medicine (TCM), in combination with Western medicine (WM), has made important and lasting contributions in the battle against COVID-19. In this review, updated clinical effects and potential mechanisms of TCM, presented in newly recognized three distinct phases of the disease, are summarized and discussed. By integrating the available clinical and preclinical evidence, the efficacies and underlying mechanisms of TCM on COVID-19, including the highly recommended three Chinese patent medicines and three Chinese medicine formulas, are described in a panorama. We hope that this comprehensive review not only provides a reference for health care professionals and the public to recognize the significant contributions of TCM for COVID-19, but also serves as an evidence-based in-depth summary and analysis to facilitate understanding the true scientific value of TCM.

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“…Along with Pneumonia No. 1 formula [ 54 ], Shufeng Jiedu capsule [ 50 ], Qingfei Paidu decoction [ 57 ], and Yidu-toxicity blocking lung decoction [ 58 ] can reduce the levels of C-reactive protein and other inflammation indicators such as erythrocyte sedimentation rate and significantly improve lung imaging indications. This shows that TCM can promote the attenuation of lung inflammation.…”

Section: Obvious Advantages Of Tcm For the Treatment Of Covid-19: Dirmentioning

confidence: 99%

The direct evidence and mechanism of traditional Chinese medicine treatment of COVID-19

Zhang

Duan

et al. 2021

Biomedicine & Pharmacotherapy

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Yidu-toxicity blocking lung decoction ameliorates inflammation in severe pneumonia of SARS-COV-2 patients with Yidu-toxicity blocking lung syndrome by eliminating IL-6 and TNF-a

Cited by 28 publications

References 34 publications

Abstracts for reports of randomized trials of COVID-19 interventions had low quality and high spin

Abstracts for reports of randomized trials of COVID-19 interventions had low quality and high spin

Traditional Chinese medicine in COVID-19

The direct evidence and mechanism of traditional Chinese medicine treatment of COVID-19

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