Yersinia pseudotuberculosis O III Causes Diarrhea in Brazilian Cattle

Warth, José Francisco Ghignatti; Biesdorf, Sonia Maria; Souza, Carlos Eduardo Alves de

doi:10.1007/978-1-4614-3561-7_13

Cited by 7 publications

(8 citation statements)

References 10 publications

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“…These strains were isolated globally from human and nonhuman sources and are described as having low pathogenic potential (Fukushima et al, 2001;Fredriksson-Ahomaa, 2007;Laukkanen-Ninios et al, 2011). Despite the low pathogenicity characteristic of Y. pseudotuberculosis O:3 strains isolated around the world, some Y. pseudotuberculosis O:3 strains isolated in Brazil were responsible for severe and sometimes fatal diarrhea in cattle (Warth et al, 2012).…”

Section: Resultsmentioning

confidence: 99%

“…According to Warth et al (2012), this difference in pathogenicity can be explained by the scarcity of available pastures in the winter and by the specific type of soil present in the southern region of Brazil. This type of soil is rich in iron and allows only limited vegetative growth during colder seasons.…”

Section: Resultsmentioning

confidence: 99%

“…Healthy animals usually have low levels of Y. pseudotuberculosis in their intestinal contents (Estima and Riet-Corrêa, 1993) in contrast to the high levels observed in sick animals (Warth et al, 2012). This bacterium has been responsible for more than 100 reported episodes of hemorrhagic gastroenteritis in Bos taurus indicus and Bubalus bubalis and only one suspected case in Sus scrofa domesticus.…”

Section: Introductionmentioning

confidence: 99%

“…This bacterium has been responsible for more than 100 reported episodes of hemorrhagic gastroenteritis in Bos taurus indicus and Bubalus bubalis and only one suspected case in Sus scrofa domesticus. However, the isolation of this pathogen from humans has never been reported in this country (Falcão et al, 2008;Warth et al, 2012).…”

Section: Introductionmentioning

confidence: 99%

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Molecular typing of Yersinia pseudotuberculosis strains isolated from livestock in Brazil

Souza

Imori

Passaglia³

et al. 2013

Genet. Mol. Res.

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ABSTRACT. Yersinia pseudotuberculosis can infect a broad range of animals. In Brazil, this bacterium has been isolated from healthy and sick animals from sporadic cases and outbreaks of hemorrhagic gastroenteritis among livestock. However, the molecular diversity of these isolates is little understood. In this study, we used multilocus sequence typing, enterobacterial repetitive intergenic consensus PCR and pulsed-field gel electrophoresis to genotype 40 Y. pseudotuberculosis strains belonging to bio-serogroups 1/O:1a and 2/O:3 isolated between 1982 and 1990 in the southern region of Brazil. All three methodologies clustered the strains into two main clusters according to their bioserogroups. Good correlations were observed between the clusters and the pathogenic potential of the strains. No correlation among the strains was observed according to geographical origin, host, place, or year of isolation. The grouping of the Y. pseudotuberculosis isolated in Brazil determined by these assays leads us to suggest that Brazilian livestock

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Molecular typing of Yersinia pseudotuberculosis strains isolated from livestock in Brazil

Souza

Imori

Passaglia³

et al. 2013

Genet. Mol. Res.

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“…It is noteworthy that human enteric yersiniosis is among the five foodborne illnesses with the greatest economic burden (8). In addition to the diseases' impact on human health, all three yersinioses are associated with a major socio-economic burden because they cause recurrent, fatal epidemics among livestock and in zoological and wildlife parks (9–17). Yersinioses are thus considered to be significant human and veterinary health problems.…”

Section: Introductionmentioning

confidence: 99%

Polymorphism in the Yersinia LcrV Antigen Enables Immune Escape From the Protection Conferred by an LcrV-Secreting Lactococcus Lactis in a Pseudotuberculosis Mouse Model

et al. 2019

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Yersinioses caused by Yersinia pestis, Yersinia pseudotuberculosis , and Yersinia enterocolitica are significant concerns in human and veterinary health. The link between virulence and the potent LcrV antigen has prompted the latter's selection as a major component of anti- Yersinia vaccines. Here, we report that (i) the group of Yersinia species encompassing Y. pestis and Y. pseudotuberculosis produces at least five different clades of LcrV and (ii) vaccination of mice with an LcrV-secreting Lactococcus lactis only protected against Yersinia strains producing the same LcrV clade as that of used for vaccination. By vaccinating with engineered LcrVs and challenging mice with strains producing either type of LcrV or a LcrV mutated for regions of interest, we highlight key polymorphic residues responsible for the absence of cross-protection. Our results show that an anti-LcrV-based vaccine should contain multiple LcrV clades if protection against the widest possible array of Yersinia strains is sought.

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