Yersinia entomophaga Tc toxin is released by T10SS-dependent lysis of specialized cell subpopulations
Oleg Sitsel,
Zhexin Wang,
Petra Janning
et al.
Abstract:Disease-causing bacteria secrete numerous toxins to invade and subjugate their hosts. Unlike many smaller toxins, the secretion machinery of most large toxins remains enigmatic. By combining genomic editing, proteomic profiling and cryo-electron tomography of the insect pathogen Yersinia entomophaga, we demonstrate that a specialized subset of these cells produces a complex toxin cocktail, including the nearly ribosome-sized Tc toxin YenTc, which is subsequently exported by controlled cell lysis using a transc… Show more
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