Yersinia Enterocolitica Infections and Pork: The Missing Link

Tauxe, Robert V.; Wauters, Georges; Goossens, Valère J.; Noyen, R. Van; Vandepitte, J.; Martin, Steven M.; Mol, Patrick De; Thiers, G

doi:10.1016/s0140-6736(87)91683-7

Cited by 300 publications

(145 citation statements)

References 25 publications

Supporting

Mentioning

136

Contrasting

Unclassified

Order By: Relevance

“…The gastrointestinal symptoms observed among the study patients tended to be generally milder than in other reports [29,30]. These relatively mild symptoms may be explained by the fact that only 40 % of patients were below the age of 10 years, as age has been shown to influence strongly the clinical presentation of disease due to Y. enterocolitica of biogroup 4 [31].…”

Section: Discussioncontrasting

confidence: 45%

Association between clinical presentation, biogroups and virulence attributes ofYersinia enterocoliticastrains in human diarrhoeal disease

1996

View full text Add to dashboard Cite

SummaryTraditionally the enteric pathogenYersinia enterocoliticahas been differentiated into biogroups. Despite being considered as non-pathogenic, biogroup 1A isolates have constituted a sizeable fraction of strains from patients with gastroenteritis in many reports. To establish a potential clinical significance for biogroup 1A isolates ofY. enterocolitica, clinical disease in patients with gastroenteritis excreting such isolates was compared with symptoms among patients found infected with pathogenic biogroups. Clinical data and isolates of 66 patients from whomY. enterocoliticahad been isolated by direct plating were available for study. There was an association between patient age below 3 years and infection with ‘pathogenic’Y. enterocolitica. The severity of gastroenteritis and other symptoms, however, did not depend on the biogroup, or the presence of the virulence plasmid in the yersinia strain isolated from the patients. Strains belonging to biogroup 1A ofY. enterocoliticashowed two clusters of ribotypes, one of which encompassed most isolates recovered from humans, the other being associated with environmental isolates. This might indicate the existence of human-adapted and potentially pathogenic strains among biogroup 1A ofY. enterocolitica.

show abstract

Section: Discussioncontrasting

confidence: 45%

Association between clinical presentation, biogroups and virulence attributes ofYersinia enterocoliticastrains in human diarrhoeal disease

1996

View full text Add to dashboard Cite

show abstract

“…It is biologically plausible that consumption of raw or undercooked pork is the main driver of yersiniosis incidence in Germany. About 90% of notified cases are typically infected with Y. enterocolitica biotype 4, serotype O :3, which is frequently isolated from pigs [2,5,[15][16][17] and pork samples [2,5], and the disease association has been established in case-control studies conducted in other countries [6][7][8][9][10]. However, the importance of raw or undercooked pork for yersiniosis in young children in Germany was previously unknown.…”

Section: Discussionmentioning

confidence: 99%

“…The main reservoir of human pathogenic serotypes, in particular serotype O :3, biotype 4, are pigs [5]. The association of disease with consumption of raw and undercooked pork or pork products is well established [6][7][8][9][10]. However, other risk factors, for example, consumption of untreated drinking water [7], eating in a canteen [10], and, for children, use of a pacifier and contact with pet dogs and cats [9] have also been described.…”

Section: Introductionmentioning

confidence: 99%

Risk factors for sporadicYersinia enterocoliticainfections, Germany 2009–2010

et al. 2011

View full text Add to dashboard Cite

SUMMARYYersinia enterocolitica is an important cause of acute gastrointestinal disease and post-infectious complications. In Germany, incidence of reported yersiniosis is relatively high compared with other countries of the European Union. Children aged <5 years are most frequently affected. The aim of our study was to identify risk factors for sporadic yersiniosis in Germany. A population-based case-control study was conducted in five federal states of Germany from April 2009 to June 2010. Cases exhibiting gastrointestinal symptoms were notified to the local health department with a Yersinia enterocolitica infection culture-confirmed from stool. Controls were selected from population registries and frequency-matched on age group and state of residency. Cases and controls received a questionnaire on possible risk factors by mail. Multivariable logistic regression modelling was used to identify risk factors and to calculate adjusted odds ratios (aORs). Population attributable fractions (PAFs) were estimated for exposures associated with yersiniosis. We analysed data on 571 case patients and 1798 controls. Consumption of raw minced pork, a dish frequently consumed even by young children in Germany, was the main risk factor for disease (aOR 4 . 7, 95 % confidence interval (CI) 3 . 5-6 . 3, PAF 30 %). This association varied by age group and, unexpectedly, was strongest for children aged <2 years (aOR 17 . 5, 95 % CI 6 . 0-51 . 2). Other independent risk factors included recent preparation of minced pork in the household (aOR 1 . 4, 95 % CI 1 . 1-1 . 9, PAF 21%), playing in a sandbox (aOR 1 . 7, 95 % CI 1 . 3-2 . 4, PAF 17 %), and contact with birds (aOR 1 . 7, 95 % CI 1 . 1-2 . 6, PAF 4%). Prevention efforts should specifically target parents and caregivers of young children and focus on the high infection risk associated with consumption of raw minced pork.

show abstract

“…Serotypes of 14 of the 20 isolates of I: enterocolitica from skeletal infections were documented in the reports reviewed; nine belonged to serotype 0 3 and three to serotype 09. Three of the four isolates in the present series belonged to serotype 09; the serotype 05.27 isolate from patient 3 has not been reported as a cause of skeletal infection, but is known to cause disease in man [41,42].…”

Section: Pathogenesismentioning

confidence: 59%

Clinical features and antibiotic treatment of septic arthritis and osteomyelitis due to Yersinia enterocolitica

Crowe

Ashford

Ispahani

1996

Journal of Medical Microbiology

View full text Add to dashboard Cite

Yersina enterocolitica bone and joint infections are rare. Over a period of 7 months four patients with deep-seated skeletal infections due to Y: enterocolitica were seen at the University Hospital, Nottingham. Sites of infection included the knee (one patient) the hip (one) and the spine (two). None of the patients had major underlying disease or risk factors for developing invasive Y: enterocolitica infection. The organisms were sensitive to the second-and third-generation cephalosporins, gentamicin and fluoroquinolones. A literature search covering the period 1970-1994 revealed 20 other cases of skeletal infections due to Y: enterocolitica; there was no uniformity in the choice of antimicrobial agent for treating these infections. Oral ciprofloxacin was used as the principal antimicrobial agent in the patients described here and therapeutic success was achieved in three of these patients. Ciprofloxacin should be considered as first line therapy for invasive infections due to Y: enterocolitica.

show abstract

Yersinia Enterocolitica Infections and Pork: The Missing Link

Cited by 300 publications

References 25 publications

Association between clinical presentation, biogroups and virulence attributes ofYersinia enterocoliticastrains in human diarrhoeal disease

Association between clinical presentation, biogroups and virulence attributes ofYersinia enterocoliticastrains in human diarrhoeal disease

Risk factors for sporadicYersinia enterocoliticainfections, Germany 2009–2010

Clinical features and antibiotic treatment of septic arthritis and osteomyelitis due to Yersinia enterocolitica

Contact Info

Product

Resources

About