Yersinia Enterocolitica

Cover, Timothy L.; Aber, Robert C.

doi:10.1056/nejm198907063210104

Cited by 533 publications

(348 citation statements)

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“…Yersinia enterocolitica has been described as an agent of bacterial gastroenteritis worldwide (reviewed in [1]). Its prevalence varies widely between geographic regions, and in colder climates Y. enterocolitica may rival salmonellae as cause of infectious gastroenteritis [2].…”

Section: Introductionmentioning

confidence: 99%

“…A special effort was made to obtain information on potential late sequelae of yersinia infection. Some patients with disease due to Y. enterocolitica develop symptoms of arthritis and erythema nodosum as late complications [1]. The possibility of an association between pathogenicity of the infecting strain and the development of these complications had not been addressed before.…”

Section: Introductionmentioning

confidence: 99%

“…The strains of yersinia were identified to species and biogroup level in standard media [12], using the following biochemical reactions at 30°C: decarboxylation of lysine and ornithine, production of urease, deamination of phenylalanine, hydrolysis of Tween 80 [13], pyrazinamide [14], ONPG, and aesculin, fermentation of glucose, mannitol, lactose, saccharose, rhamnose, dulcitol, raffinose, cellobiose, melibiose, inositol, sorbitol, xylose, and mucate, utilisation of malonate, citrate and acetate, production of gas, acetoin, indole, and H2S, and the methyl-red reaction. Motility was tested at 30°C and 37 'C, and congo-red binding as well as low-calcium-response were determined on congo-red magnesium oxalate agar [15] [1]. Food histories were.…”

Section: Introductionmentioning

confidence: 99%

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Association between clinical presentation, biogroups and virulence attributes ofYersinia enterocoliticastrains in human diarrhoeal disease

1996

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SummaryTraditionally the enteric pathogenYersinia enterocoliticahas been differentiated into biogroups. Despite being considered as non-pathogenic, biogroup 1A isolates have constituted a sizeable fraction of strains from patients with gastroenteritis in many reports. To establish a potential clinical significance for biogroup 1A isolates ofY. enterocolitica, clinical disease in patients with gastroenteritis excreting such isolates was compared with symptoms among patients found infected with pathogenic biogroups. Clinical data and isolates of 66 patients from whomY. enterocoliticahad been isolated by direct plating were available for study. There was an association between patient age below 3 years and infection with ‘pathogenic’Y. enterocolitica. The severity of gastroenteritis and other symptoms, however, did not depend on the biogroup, or the presence of the virulence plasmid in the yersinia strain isolated from the patients. Strains belonging to biogroup 1A ofY. enterocoliticashowed two clusters of ribotypes, one of which encompassed most isolates recovered from humans, the other being associated with environmental isolates. This might indicate the existence of human-adapted and potentially pathogenic strains among biogroup 1A ofY. enterocolitica.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Association between clinical presentation, biogroups and virulence attributes ofYersinia enterocoliticastrains in human diarrhoeal disease

1996

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“…The initial intestinal infection with Y enterocolitica can be followed by extraintestinal immunologic diseases involving the connective tissue, such as reactive arthritis, erythema nodosum, uveitis, and some forms of vasculitis (8). It has been shown that reactive arthritis is associated with the presence of antigens from the initiating microorganism in the affected joints, and it is speculated that these antigens trigger the disease (9).…”

mentioning

confidence: 99%

Characterization of the binding region for the yersinia enterocolitica adhesin yada on types i and ii collagen

Schulze‐Koops

Burkhardt

Heesemann

et al. 1995

Arthritis & Rheumatism

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Objective. The plasmid-encoded adhesin YadA confers pathogenic functions on Yersinia enterocolitica, a microorganism associated with reactive arthritis. While emerging evidence has indicated that the persistence of the bacteria in individuals with reactive arthritis is a prerequisite for the development of the disease, the tissue specificity of this immunologic disease sequela remains elusive. The present study was undertaken to investigate YadA-mediated binding of Y enterocolitica to the most abundant collagens in joints, types I and I1 collagen.Methods. Binding studies were performed with recombinant Y enterocoliticu strains and highly purified type I1 collagen and the d ( I ) chain of type I collagen, or fragments of these collagens generated by various enzymatic and nonenzymatic cleavage procedures. Interactions of bacteria with the proteins were determined in binding assays with radiolabeled proteins.Results. Binding regions for YadA were identified at the 181-amino acid fragment d(I)78CBN of type I collagen and the CBlO fragment of type I1 collagen. From binding and blocking experiments with al(1) fragments, cyanogen bromide-derived or mammalian collagenasderived type I1 collagen fragments, and synthetic peptides with collagen-like structures, it was ~~~

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“…It is associated with a wide spectrum of clinical and immunological manifestations, responsible for digestive diseases, including enterocolitis and mesenteric adenitis, as well as extra-digestive manifestations including respiratory tract and urinary tract infection, osteoarticular infection, erythema nodosum and endocarditis [1]. Bacteremia and sepsis are most often reported in patients with predisposing underlying disease, such as an iron-overloaded state (haemochromatosis, acute iron poisoning), immunosuppressive therapy, diabetes mellitus, alcoholism, cirrhosis or malnutrition.…”

Section: Correspodencementioning

confidence: 99%