Yeni 1,3,4-Tiyadiazol-Piperazin Türevlerinin Sentezi, İn Vitro Antikolinesteraz ve Antimikrobiyal Değerlendirilmesi

Abstract

In this study, 8 new compounds having 2-((5-substituted-1,3,4-thiadazol-2-yl)amino)-2-oxoethyl-4substituepiperazine-1-carbodithioate structures were synthesized, antimicrobial and anticholinesterase activities were evaluated. The structures of synthesized compounds were proved by 1 H NMR, 13 C NMR and mass spectra. The synthesized compounds were tested for antibacterial activity against eight bacteria strains and antifungal activity against four fungus strains. When the antibacterial activities of the compounds were examined, it was found that the compounds 3c, 3d, 3g and 3h were effective against E. faecalis (ATCC 29212) and E. faecalis (ATCC 51922) with MIC value of 25 µg/mL. It was determined that the carbon chain at the para position of piperazine increased the activity but where as the addition of benzyl group to the para position (3a, 3b, 3e, 3f) did not affect the activity. Furthermore, the acetylcholinesterase activity of the synthesized compounds was examined but none of the compounds showed AChE inhibitory activity as much as standard drug Donepezil.