Yellow phosphorus poisoning and living donor liver transplant - A case report

Babu, Rakesh; Kanianchalil, Kishore; Kumar, Anish; Rajan, Rajneesh; Sahadevan, Sajeesh; Nambiar, Rajesh

doi:10.4103/ijot.ijot_18_20

Cited by 2 publications

(2 citation statements)

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“…There is no specific antidote for YP intoxication. Early gastric lavage and supportive therapy in the form of N-acetyl cysteine (NAC) infusion are important in management [1,2,5,6]. While NAC is traditionally indicated in acetaminophen-induced liver toxicity, it is also useful in non-acetaminophen induced liver failure by replenishing glutathione stores and improving the activity of glutathione transferase.…”

Section: Ravikanti Et Almentioning

confidence: 99%

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Liver transplantation for fulminant hepatic failure in yellow phosphorus poisoning

Ravikanti¹,

Yadav²,

Rangappa³

et al. 2022

Indian J Case Reports

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Yellow phosphorus (YP) containing rodenticides is a readily available poison that may be accidentally or deliberately ingested, leading to symptoms ranging from simple gastrointestinal symptoms to fulminant hepatic failure, depending on the amount ingested. As there is no specific antidote, the treatment requires early gastric lavage and institution of supportive measures such as acetyl cysteine infusion and Vitamin K. Progression to fulminant hepatic failure is characterized by rapid deterioration of liver function tests, worsening coagulopathy, and sensorium. The only definitive treatment at this stage is a liver transplant and therapeutic plasma exchange (TPE) can serve as a bridge therapy until a compatible liver donor is found. We present a case of YP-containing rodenticide poisoning, in which the patient progressed to fulminant hepatic failure despite aggressive supportive therapy and was successfully managed with TPE until liver transplantation.

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Section: Ravikanti Et Almentioning

confidence: 99%

“…Acute tubular necrosis is a common complication of YP poisoning resulting from direct toxicity and occasionally, rhabdomyolysis [3,6,13]. Continuous renal replacement therapy (CRRT) can be used as bridge therapy while waiting for the liver transplant.…”

Section: Ravikanti Et Almentioning

confidence: 99%