Yellow nail syndrome associated with mental retardation in two siblings

Kamatani, M.; Rai, A.; Hen, Hidetoshi; Hayashi, Kappei; Aoki, Toyoaki; Umeyama, Kaoru; Takebayashi, Jun

doi:10.1111/j.1365-2133.1978.tb02005.x

Cited by 29 publications

(21 citation statements)

References 5 publications

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“…Many of the reported cases have been sporadic, in addition to reports of autosomal dominant inheritance with variable expression [Wells, 1966;Emerson, 1966, Kleinman, 1973. The condition may be heterogeneous, given the report of two affected sibs with intellectual handicap and consanguineous parents (double first cousins), suggesting autosomal recessive inheritance in this particular family [Kamatani et al, 1978].…”

Section: Discussionmentioning

confidence: 91%

Yellow nail syndrome presenting as non-immune hydrops: Second case report

et al. 2000

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The yellow nail syndrome is characterized by slowly growing yellow discolored nails and lymphoedema, with onset generally after puberty. We report on a newborn infant who, at 23 weeks, was found to have hydrops on antenatal ultrasonography and bilateral chylothorax at delivery. His mother has the yellow nail syndrome, with typical nail changes, and bronchiectasis. There seemed to be no other etiology for the non-immune hydrops, and this is the second documented case of the prenatal manifestation of this condition.

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Section: Discussionmentioning

confidence: 91%

Yellow nail syndrome presenting as non-immune hydrops: Second case report

et al. 2000

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“…Yellow nail syndrome often appears in adults in a sporadic manner but occurrences have also been reported in conjunction with multiple diseases, immune deficiencies, drug therapies and as a paraneoplastic syndrome. It has rarely been reported in children (Table 1) and to date there is only one report of siblings with YNS (2).…”

Section: Previously Reported Occurrences Of Yellow Nail Syndrome In mentioning

confidence: 99%

Yellow Nail Syndrome in Three Siblings: A Randomized Double‐Blind Trial of Topical Vitamin E

Lambert

Dziura

Kauls

et al. 2006

Pediatric Dermatology

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Yellow nail syndrome is an uncommon disorder characterized by dystrophic nails, lymphedema, and respiratory disease. It has rarely been reported in children and this is the first report of congenital yellow nails in siblings. The purpose of this study was to determine whether topical vitamin E applied to the nail plates and periungual skin would affect the growth rate or appearance of the fingernails in patients with congenital yellow nail syndrome. This study was the first trial of a treatment for this entity in children and the largest randomized double blind trial to date. We found that vitamin E solution had no significant effect (p = 0.84) on fingernail growth or the global appearance score (p = 1.0) when compared with placebo. The average growth rates and global assessment scores improved and onycholysis and onychomadesis decreased from baseline with both vitamin E and placebo treatment, although these were not primary end points of the study. Topical vitamin E did not result in a statistically significant improvement when compared with oil alone for the treatment of the nails in our three patients with yellow nail syndrome. However, it is interesting and perhaps clinically useful that both vitamin E and placebo oil improved the condition of the nails.

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“…Kamatani et al. 16 described two siblings with YNS and associated mental retardation. Govaert et al.…”

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confidence: 99%