Yellow Nail Induced by Bucillamine

Ishizaki, C T Sachie; Sueki, Hirohiko; Kohsokabe, Shigeru; Nishida, Hisashi

doi:10.1111/j.1365-4362.1995.tb00621.x

Cited by 19 publications

(4 citation statements)

References 6 publications

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“…5 YNS has also been reported with a variety of other conditions including autoimmune disease, 6 immunodeficiency states, 7 Guillain-Barré syndrome 8 and with the use of certain drugs. 9 YNS has also been reported in association with a variety of malignancies including carcinoma of the breast, 3 lung 5 and gall bladder, 10 and lymphoma. 11,12 It has therefore been suggested that YNS may represent a paraneoplastic phenomenon.…”

mentioning

confidence: 98%

Yellow nail syndrome: not a genetic disorder? Eleven new cases and a review of the literature

2007

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mentioning

confidence: 98%

Yellow nail syndrome: not a genetic disorder? Eleven new cases and a review of the literature

2007

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“…Exposure to titanium dioxide occurs from orthopedic implants along with ingestion of some medications or foods (table 1). Reports in the literature have suggested a role of medications in the development of YNS [10,11,12]. Initially thought to be secondary to the active ingredient, it may in fact be due to the presence of titanium dioxide in the formulation.…”

Section: Discussionmentioning

confidence: 99%

Role of Titanium in the Development of Yellow Nail Syndrome

Decker

Daly

Scher

2015

Skin Appendage Disord

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Yellow nail syndrome (YNS) is characterized by the triad of nail changes, lymphedema and respiratory tract involvement. Several hypotheses have been postulated to explain the findings in YNS including lymphatic drainage abnormalities along with microvasculopathy. The most recent hypothesis, proposed by Berglund and Calmark [Biol Trace Elem Res 2011;143:1-7], suggests a role of titanium dioxide in the development of YNS. This study showed elevated titanium levels (ranging from 1.1 to 170 μg/g of nail plate) in nail clippings or pieces of shed nail from 30 patients with YNS. Titanium was not found in the nails of healthy patients. Complete resolution was seen in 4 patients after removal of their titanium implants. Titanium dioxide is commonly found in cosmetics, sunscreens, medications, confectionaries and joint implants. Exposure to titanium can lead to its ions being released by galvanic action of dental gold or amalgam through the oxidative stress of fluorides. It is hypothesized that this galvanic interaction may lead to the yellow discoloration. At this point, cause and effect is speculative, but titanium may play a role in a subgroup of patients with YNS.

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“…[33][34][35][36] Functional abnormalities are favored over anatomic abnormalities, because there have been cases of patients who spontaneously improved. [33][34][35][36] Furthermore, YNS has been associated with a number of systemic diseases including rheumatoid arthritis, [42][43][44] Guillain-Barre syndrome, 45 drugs such as bucillamine (a treatment for rheumatoid arthritis), 43,44,46,47 and certain cancers including breast, 39 lung, 48 gallbladder, 49 and lymphoma. 41,50,51 In YNS, nail changes occur in virtually all patients and represent the presenting sign in up to 30% of cases.…”

Section: Yellow Nail Syndromementioning

confidence: 99%