Yellow fever virus: Genetic and phenotypic diversity and implications for detection, prevention and therapy

Beasley, David W.C.; McAuley, Alexander J.; Bente, Dennis A.

doi:10.1016/j.antiviral.2014.12.010

Cited by 63 publications

(97 citation statements)

References 252 publications

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“…All three TBEV subtypes can and do co-circulate (e.g., in the Baltics) and data suggest that vaccines based on one subtype may also be effective against other subtypes and vice versa [42,50–53]. Similarly, YFV can be divided into seven major genotypes- five African and two South American [54] and it is generally accepted that strains of YFV constitute a single antigenic type (or serotype). However, differences in antigenicity between YFV strains, or between wild type and vaccine viruses, have been detected using mouse [55–60] and human [61] monoclonal and polyclonal antibodies.…”

Section: Discussionmentioning

confidence: 99%

Heterologous Protection against Asian Zika Virus Challenge in Rhesus Macaques

et al. 2016

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BackgroundZika virus (ZIKV; Flaviviridae, Flavivirus) was declared a public health emergency of international concern by the World Health Organization (WHO) in February 2016, because of the evidence linking infection with ZIKV to neurological complications, such as Guillain-Barre Syndrome in adults and congenital birth defects including microcephaly in the developing fetus. Because development of a ZIKV vaccine is a top research priority and because the genetic and antigenic variability of many RNA viruses limits the effectiveness of vaccines, assessing whether immunity elicited against one ZIKV strain is sufficient to confer broad protection against all ZIKV strains is critical. Recently, in vitro studies demonstrated that ZIKV likely circulates as a single serotype. Here, we demonstrate that immunity elicited by African lineage ZIKV protects rhesus macaques against subsequent infection with Asian lineage ZIKV.Methodology/Principal FindingsUsing our recently developed rhesus macaque model of ZIKV infection, we report that the prototypical ZIKV strain MR766 productively infects macaques, and that immunity elicited by MR766 protects macaques against heterologous Asian ZIKV. Furthermore, using next generation deep sequencing, we found in vivo restoration of a putative N-linked glycosylation site upon replication in macaques that is absent in numerous MR766 strains that are widely being used by the research community. This reversion highlights the importance of carefully examining the sequence composition of all viral stocks as well as understanding how passage history may alter a virus from its original form.Conclusions/SignificanceAn effective ZIKV vaccine is needed to prevent infection-associated fetal abnormalities. Macaques whose immune responses were primed by infection with East African ZIKV were completely protected from detectable viremia when subsequently rechallenged with heterologous Asian ZIKV. Therefore, these data suggest that immunogen selection is unlikely to adversely affect the breadth of vaccine protection, i.e., any Asian ZIKV immunogen that protects against homologous challenge will likely confer protection against all other Asian ZIKV strains.

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Section: Discussionmentioning

confidence: 99%

Heterologous Protection against Asian Zika Virus Challenge in Rhesus Macaques

et al. 2016

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“…Our studies also showed rapid progression in disease pathogenesis with MR 766 as compared to equivalent challenge with FSS 13025 in AG129 mice. Vaccines derived from single antigenic serotype have also been effective against other flaviviruses such as Yellow fever virus30, Tick-borne encephalitis3132, and Japanese encephalitis3334 viruses that exist as multiple genotypes.…”

Section: Discussionmentioning

confidence: 99%

Protective efficacy of Zika vaccine in AG129 mouse model

Sumathy

Kulkarni

Gondu

et al. 2017

Sci Rep

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Zika virus (ZIKV) is a mosquito-borne flavivirus that causes asymptomatic infection or presents only mild symptoms in majority of those infected. However, vaccination for ZIKV is a public health priority due to serious congenital and neuropathological abnormalities observed as a sequelae of the virus infection in the recent epidemics. We have developed an inactivated virus vaccine with the African MR 766 strain. Here we show that two doses of the vaccine provided 100% efficacy against mortality and disease following challenge with homotypic MR 766 and the heterotypic FSS 13025 ZIKV strains in the Type I and Type II interferon deficient AG129 mice. Two doses of the vaccine elicited high titer of neutralizing antibodies in Balb/c mice, and the vaccine antisera conferred protection against virus challenge in passively immunized mice. The studies were useful to rationalize vaccine doses for protective efficacy. Furthermore, the vaccine antisera neutralized the homotypic and heterotypic ZIKV strains in vitro with equivalent efficiency. Our study suggests a single ZIKV serotype, and that the development of an effective vaccine may not be limited by the choice of virus strain.

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“…The occurrence of four DENV 320 serotypes and the ability of immune enhancement to augment 321 their circulation probably also give an edge to DENV as to CHIKV is yellow fever virus (YFV), which also 325 evolved in sub-Saharan Africa in similar, if not identical enzootic 326 cycles involving NHPs and arboreal Aedes vectors(Bryant et al, 327 2007;Wang et al, 1996). Like CHIKV, YFV has limited antigenic 328 and genetic diversity in Africa, with no evidence of sequential 329 infections or immune enhancement(Beasley et al, 2015).330 Enzootic strains of all three viruses appear to be capable of exploit-331 ing A. aegypti as an efficient urban vector without any detectable 332 adaptation. This facilitated the transport of these via sailing ships 333 during past centuries, where they caused periodic outbreaks in 334 port cities by transporting both the viruses and mosquito, probably 335 with onboard circulation among sailors and passengers.…”

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confidence: 99%