Yeasties and beasties: 7 years of genome sequencing

Abstract

Xbstract The Saccharomyces cerevisiae genome sequencing project was the first of many projects aimed at sequencing the entire genomes of model organisms. Since its initiation in 1989, there have been numerous debates about the validity of genome ~equencing, especially with reference to the model organisms. .',;even years on, I hope to satisfy some of the critics by demonstrating that, as a consequence of the mass of data now becoming available from such projects, and the beginning of the major collaborative effort to sequence the human genome, we are now entering an exciting and dynamic time for those involved not only in genome sequencing, but also in all areas of the biological ,ciences.

Harnessing the Power of the Genome in the Search for New Antibiotics

“…However, determination and characterization of smaller, less complex genomes, notably bacteria and yeast, has preceded that of the human genome, providing a testing ground for high-throughout screening procedures. For example, the Saccharomyces cerevisiae genome project, which delivered the first complete eukaryotic genome with 16 chromosomes and about 6200 genes (7), provides a model for ways in which DNA sequence information can be used to direct the subsequent systematic study of biochemical and functional processes (2,3). Furthermore, new approaches are being developed for extracting information concerning gene expression, protein levels, subcellular localization and AstraZeneca, Alderley Park, Macclesfield, Cheshire SK10 4TC, UK.…”