Yeast shuttling SR-proteins Npl3p, Gbp2p and Hrb1p are part of the translating mRNPs and Npl3p can function as a translational repressor

Krebber, Heike; Sturm, Dorothée; Windgassen, Merle; Cajigas, Iván J.; González, Caleb; Seedorf, Matthias; Bastians, Holger

doi:10.1240/sav_gbm_2005_h_001267

Cited by 1 publication

(1 citation statement)

References 21 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In humans, among the 12 known SR proteins, some are removed from the mRNP as soon as splicing is successfully completed, while others are exported to the cytoplasm together with it [ 36 ]. On the contrary, in yeast, all the three known SR proteins (Npl3, Gbp2 and Hrb1) remain attached to the mRNP all over the export process, and are only released in the cytoplasm [ 37 , 38 , 39 ], although it is not clear how they are released [ 40 ].…”

Section: Nuclear Processing Of Rnamentioning

confidence: 99%

The Great Escape: mRNA Export through the Nuclear Pore Complex

Magistris

2021

IJMS

View full text Add to dashboard Cite

Nuclear export of messenger RNA (mRNA) through the nuclear pore complex (NPC) is an indispensable step to ensure protein translation in the cytoplasm of eukaryotic cells. mRNA is not translocated on its own, but it forms ribonuclear particles (mRNPs) in association with proteins that are crucial for its metabolism, some of which; like Mex67/MTR2-NXF1/NXT1; are key players for its translocation to the cytoplasm. In this review, I will summarize our current body of knowledge on the basic characteristics of mRNA export through the NPC. To be granted passage, the mRNP cargo needs to bind transport receptors, which facilitate the nuclear export. During NPC transport, mRNPs undergo compositional and conformational changes. The interactions between mRNP and the central channel of NPC are described; together with the multiple quality control steps that mRNPs undergo at the different rings of the NPC to ensure only proper export of mature transcripts to the cytoplasm. I conclude by mentioning new opportunities that arise from bottom up approaches for a mechanistic understanding of nuclear export.

show abstract

Section: Nuclear Processing Of Rnamentioning

confidence: 99%

The Great Escape: mRNA Export through the Nuclear Pore Complex

Magistris

2021

IJMS

View full text Add to dashboard Cite

show abstract

Yeast shuttling SR-proteins Npl3p, Gbp2p and Hrb1p are part of the translating mRNPs and Npl3p can function as a translational repressor

Cited by 1 publication

References 21 publications

The Great Escape: mRNA Export through the Nuclear Pore Complex

The Great Escape: mRNA Export through the Nuclear Pore Complex

Contact Info

Product

Resources

About