Yeast hydrolysate induces longitudinal bone growth and growth hormone release in rats

Abstract

This study investigated the growth promoting effects of yeast extract (YH) fed to Sprague-Dawley male rats (3 weeks old) for 4 weeks. The negative (N)-control and positive (P)-control groups were given a daily oral administration of saline and foremilk (1 g/kg of BW), respectively, and the YH-1 and YH-2 groups were given daily administrations of YH (0.5 and 1 g/kg of BW, respectively). After 4 weeks, the YH-1, YH-2 and P-control groups showed significant differences in the body weight gain compared with the N-control group (p < 0.05). The YH-1 and YH-2 groups also had significantly different tibial bone growths (0.47 and 0.49 mm/day, respectively) and femur bone growths (0.52 and 0.53 mm/day, respectively) compared with the N-control group (0.37 mm/day of tibial growth and 0.42 mm/day of femur growth) (p < 0.05). The YH-1 and YH-2 groups had significantly different growth plate (proximal epiphysis) height increments (0.62 and 0.56 mm, respectively) compared with the N-control group (0.17 mm) (p < 0.05). Lastly, the YH-1 and YH-2 groups presented different growth hormone (GH) levels (1.77 and 2.10 ng/mL, respectively) than the N-control group (0.82 ng/mL) (p < 0.05). YH administration increased longitudinal bone growth and GH secretion in rats. Consequently, YH may offer an improved ability to treat GH deficiency-related disorders.

Growth sensitivity in the epiphyseal growth plate, liver and muscle of SD rats is significantly enhanced by treatment with a fermented soybean product (cheonggukjang) through stimulation of growth hormone secretion

“…The synthesis and secretion of GH in somatotroph cells of the anterior pituitary gland may be induced by several natural products (17,18). For instance, administration of yeast extract for four weeks was shown to increase the body weight and GH secretion of young SD male rats (19). The bioassay-guided fraction of MeOH extract from the fenugreek (Trigonella foenum-graecum L.) seed stimulates the release of GH from rat pituitary cells.…”

The effects of &lt;i&gt;Saccharomyces cerevisiae&lt;/i&gt; on the morphological and biomechanical characteristics of the tibiotarsus in broiler chickens

“…Kim et al (2009) and Lee et al (2011) reported that yeast hydrolysate increased the proximal epiphyseal length of bone, accelerated its longitudinal extension and stimulated growth hormone secretion in young rats. There is no study of the effect of the yeast on the epiphyseal growth plate of broiler chickens.…”

“…Leg abnormalities cause pain and discomfort for broilers Mcgeown et al, 1999), and severe lameness limits the broilers' access to feeders and water Knowles et al, 2008). Consequently, chickens can be exposed to hunger, thirst, and dehydration (Butterworth et al, 2002).…”

Safety Study of Yeast Hydrolysate with below 10 kDa Molecular Weight in Animal Models

“…6,7) Recently, yeast hydrolysate has revealed various physiological effect of according to molecular weight. In Kim et al study, 8) yeast hydrolysate with 10-30 kDa molecular weight increased longitudinal bone growth and growth hormone secretion in adolescent Sprague-Dawley (SD) rats. And yeast hydrolysate with below 10 kDa molecular weight has displayed the anti-obesity effects in SD rats fed a high fat diet and obese women.…”