Yeast eIF2A has a minimal role in translation initiation and uORF-mediated translational controlin vivo
Swati Gaikwad,
Fardin Ghobakhlou,
Hongen Zhang
et al.
Abstract:Initiating translation of most eukaryotic mRNAs depends on recruitment of methionyl initiator tRNA (Met- tRNAi) in a ternary complex (TC) with GTP-bound eukaryotic initiation factor 2 (eIF2) to the small (40S) ribosomal subunit, forming a 43S preinitiation complex (PIC) that attaches to the mRNA and scans the 5’- untranslated region (5’ UTR) for an AUG start codon. Previous studies have implicated mammalian eIF2A in GTP-independent binding of Met-tRNAi to the 40S subunit and its recruitment to specialized mRNA… Show more
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