Year in review in Intensive Care Medicine, 2008: III. Paediatrics, Ethics, outcome research and critical care organization, sedation, pharmacology and miscellanea

Antonelli, Massimo; Azoulay, Élie; Bonten, Marc J. M.; Chastre, Jean; Citerio, Giuseppe; Conti, Giorgio; Backer, Daniel De; Lemaire, François; Gerlach, Herwig; Groeneveld, Johan; Hedenstierna, Göran; MacRae, Duncan; Mancebo, Jordi; Maggiore, Salvatore Maurizio; Mebazaa, Alexandre; Metnitz, Philipp; Pugin, Jérôme; Wernerman, Jan; Zhang, Haibo

doi:10.1007/s00134-009-1433-4

Cited by 5 publications

(4 citation statements)

References 71 publications

(60 reference statements)

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“…Monitoring a single transition per peptide has been proposed as being sufficiently specific for peptide quantitation in complex mixtures such as plasma 33 . Classical biomarkers do not add more information than generic scores to predict outcome in septic patients 34 , and the future treatment of sepsis requires finding new biomarkers that are sensitive, specific and economically affordable.…”

Section: Discussionmentioning

confidence: 99%

A new mass spectrometry-based method for the quantification of histones in plasma from septic shock patients

García-Giménez

Romá-Mateo

Carbonell

et al. 2017

Sci Rep

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The aim of this study was to develop a novel method to detect circulating histones H3 and H2B in plasma based on multiple reaction monitoring targeted mass spectrometry and a multiple reaction monitoring approach (MRM-MS) for its clinical application in critical bacteriaemic septic shock patients. Plasma samples from 17 septic shock patients with confirmed bacteraemia and 10 healthy controls were analysed by an MRM-MS method, which specifically detects presence of histones H3 and H2B. By an internal standard, it was possible to quantify the concentration of circulating histones in plasma, which were significantly higher in patients, and thus confirmed their potential as biomarkers for diagnosing septic shock. After comparing surviving patients and non-survivors, a correlation was found between higher levels of circulating histones and unfavourable outcome. Indeed, histone H3 proved a more efficient and sensitive biomarker for septic shock prognosis. In conclusion, these findings suggest the accuracy of the MRM-MS technique and stable isotope labelled peptides to detect and quantify circulating plasma histones H2B and H3. This method may be used for early septic shock diagnoses and for the prognosis of fatal outcomes.

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Section: Discussionmentioning

confidence: 99%

A new mass spectrometry-based method for the quantification of histones in plasma from septic shock patients

García-Giménez

Romá-Mateo

Carbonell

et al. 2017

Sci Rep

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“…Classical biomarkers have not been shown to be better than generic scores in predicting outcome in septic patients [ 27 ]. Based on the results obtained in the first 24 hours, we have established the characteristic metabolic phenotype of a septic patient with a good performance against the worst prognosis as a combination of eight urine metabolite levels.…”

Section: Discussionmentioning

confidence: 99%

Prognosis Biomarkers of Severe Sepsis and Septic Shock by 1H NMR Urine Metabolomics in the Intensive Care Unit

et al. 2015

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Early diagnosis and patient stratification may improve sepsis outcome by a timely start of the proper specific treatment. We aimed to identify metabolomic biomarkers of sepsis in urine by 1H-NMR spectroscopy to assess the severity and to predict outcomes. Urine samples were collected from 64 patients with severe sepsis or septic shock in the ICU for a 1H NMR spectra acquisition. A supervised analysis was performed on the processed spectra, and a predictive model for prognosis (30-days mortality/survival) of sepsis was constructed using partial least-squares discriminant analysis (PLS-DA). In addition, we compared the prediction power of metabolomics data respect the Sequential Organ Failure Assessment (SOFA) score. Supervised multivariate analysis afforded a good predictive model to distinguish the patient groups and detect specific metabolic patterns. Negative prognosis patients presented higher values of ethanol, glucose and hippurate, and on the contrary, lower levels of methionine, glutamine, arginine and phenylalanine. These metabolites could be part of a composite biopattern of the human metabolic response to sepsis shock and its mortality in ICU patients. The internal cross-validation showed robustness of the metabolic predictive model obtained and a better predictive ability in comparison with SOFA values. Our results indicate that NMR metabolic profiling might be helpful for determining the metabolomic phenotype of worst-prognosis septic patients in an early stage. A predictive model for the evolution of septic patients using these metabolites was able to classify cases with more sensitivity and specificity than the well-established organ dysfunction score SOFA.

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“…[1][2][3][4] It has been estimated that in the US alone, over three million children are diagnosed with community-acquired pneumonia each year, with > 150,000 of these requiring hospitalization. [1][2][3][4] It has been estimated that in the US alone, over three million children are diagnosed with community-acquired pneumonia each year, with > 150,000 of these requiring hospitalization.…”

Section: Introductionmentioning

confidence: 99%

A Randomized, Prospective Study of Pediatric Patients With Community-acquired Pneumonia Treated With Ceftaroline Versus Ceftriaxone

Cannavino

Németh

Korczowski

et al. 2016

Pediatric Infectious Disease Journal

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Year in review in Intensive Care Medicine, 2008: III. Paediatrics, Ethics, outcome research and critical care organization, sedation, pharmacology and miscellanea

Cited by 5 publications

References 71 publications

A new mass spectrometry-based method for the quantification of histones in plasma from septic shock patients

A new mass spectrometry-based method for the quantification of histones in plasma from septic shock patients

Prognosis Biomarkers of Severe Sepsis and Septic Shock by 1H NMR Urine Metabolomics in the Intensive Care Unit

A Randomized, Prospective Study of Pediatric Patients With Community-acquired Pneumonia Treated With Ceftaroline Versus Ceftriaxone

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