Year in review in Intensive Care Medicine 2009. Part III: Mechanical ventilation, acute lung injury and respiratory distress syndrome, pediatrics, ethics, and miscellanea
“…The second period of our study, after the new French legislation of 2005, saw the rate of deaths after limiting of life-sustaining therapy increase to 85% in our department, which is coherent with the rates reported in other studies conducted after 2005 [2,[16][17][18]. It should be noted that studies conducted in different religious or geographic contexts, particularly within Europe, can give differing results.…”
Section: Discussionsupporting
confidence: 75%
“…Several studies assessing the collegial nature of decisions to forego lifesustaining therapy mention the lack of communication and interaction between the caregivers and the patient's close family members when discussing the patient's future [19][20][21]. Indeed, Stricker et al [16,22] highlighted the need for improved emotional support, coordination of care and communication in their study of family satisfaction among the relatives of 996 Swiss ICU patients. Therefore, it is of particular importance to have an intensive communication strategy involving all staff members as well as the patient's family and/or appointed surrogates.…”
“…The second period of our study, after the new French legislation of 2005, saw the rate of deaths after limiting of life-sustaining therapy increase to 85% in our department, which is coherent with the rates reported in other studies conducted after 2005 [2,[16][17][18]. It should be noted that studies conducted in different religious or geographic contexts, particularly within Europe, can give differing results.…”
Section: Discussionsupporting
confidence: 75%
“…Several studies assessing the collegial nature of decisions to forego lifesustaining therapy mention the lack of communication and interaction between the caregivers and the patient's close family members when discussing the patient's future [19][20][21]. Indeed, Stricker et al [16,22] highlighted the need for improved emotional support, coordination of care and communication in their study of family satisfaction among the relatives of 996 Swiss ICU patients. Therefore, it is of particular importance to have an intensive communication strategy involving all staff members as well as the patient's family and/or appointed surrogates.…”
“…5,6 At the same time, family members find it difficult to hear bad news and may respond in ways that undercut their desire to hear prognostic information. [7][8][9] Some surrogates ask not to be given bad news. Others accept prognostic information yet retain alternate beliefs, for example, by remaining optimistic that a patient will recover in the face of a grim outlook.…”
Surrogates in the ICU experience conflicting emotional and informational needs. They describe behaviors that give the appearance of avoiding bad news while simultaneously asking physicians to help them cope with prognostic information.
“…Nevertheless, it is used extensively in the pediatric population in general critical care [6–9], cardiac critical care [10–14], cardiac anesthesia [15], general anesthesia [16], and ambulatory anesthesia [17] due its ability to produce sedation, anxiolysis and analgesia while minimally affecting respiratory function [2–5]. Despite the widespread use of dexmedetomidine, current literature contains little information regarding experience with prolonged infusions and few case reports describe possible rebound or withdrawal symptoms after its discontinuation [18–21].…”
Purpose
To describe changes in hemodynamic variables, sedation and pain score after discontinuation of prolonged infusions of dexmedetomidine in a pediatric population of critically ill cardiac patients.
Methods
Retrospective case series of patients who received continuous infusions of dexmedetomidine for longer than 3 days in a pediatric cardiac intensive care unit from 2008 to 2010.
Results
Sixty-two patients, age 5.2 months (range 0.3 months – 17 years) and weight 5.1 kg (range 2.2–84 kg), were included. Thirty-nine patients (63%) were <1 year of age. Median duration of dexmedetomidine infusion was 5.8 days (range 4–26 days) and median infusion dose was 0.71 μg/kg/hr (range 0.2–2.1 μg/kg/hr). Median weaning time and dose at discontinuation were 43 hours (range 0–189 hours) and 0.2 μg/kg/hr (range 0.1–1.3 μg/kg/hr). Tachycardia, transient hypertension and agitation were observed in 27%, 35% and 27% of patients. Episodes of tachycardia were more frequent in children >1 year of age (61% vs. 8%, p < .001), patients who received dexmedetomidine for 4 days when compared to those who received 5 days or longer (48% vs. 17%, p = .011) and patients whose infusion was discontinued abruptly (42% vs. 14%, p = .045). Tachyarrhythmias were seen in 9 patients (15%) after discontinuation of the dexmedetomidine infusion. Adequate sedation and analgesia scores at the moment of infusion discontinuation were seen in 90% and 88%, of patients respectively.
Conclusions
Our study suggests that tachycardia, transient hypertension and agitation are frequently observed in pediatric cardiac intensive care unit patients after discontinuing prolonged dexmedetomidine infusions.
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