Year in review in Intensive Care Medicine 2011. II. Cardiovascular, infections, pneumonia and sepsis, critical care organization and outcome, education, ultrasonography, metabolism and coagulation

Antonelli, Massimo; Bonten, Marc J. M.; Chastre, Jean; Citerio, Giuseppe; Conti, Giorgio; Curtis, J. Randall; Backer, Daniel De; Hedenstierna, Göran; Joannidis, Michael; MacRae, Duncan; Mancebo, Jordi; Maggiore, Salvatore Maurizio; Mebazaa, Alexandre; Preiser, Jean-Charles; Rocco, Patricia R. M.; Timsit, Jean François; Wernerman, Jan; Zhang, Haibo

doi:10.1007/s00134-012-2467-6

Cited by 39 publications

(15 citation statements)

References 74 publications

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“…The clinical syndrome of sepsis results from the individual's response to an infective process, and may be associated with profound haemodynamic disturbance [1,2]. Sepsis still accounts for substantial mortality and morbidity with circulatory failure and consequential multi-organ failure the main mechanism [3].…”

Section: Introductionmentioning

confidence: 99%

“…Sepsis still accounts for substantial mortality and morbidity with circulatory failure and consequential multi-organ failure the main mechanism [3]. Septic shock is characterized by profound vasodilation requiring administration of vasopressor agents to maintain organ perfusion [2]. Additionally, septic patients may exhibit pronounced myocardial dysfunction [4,5], not only with left and/or right ventricular (LV and/or RV) systolic impairment [6] but also with reversible LV diastolic dysfunction (DD) [7].…”

Section: Introductionmentioning

confidence: 99%

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Diastolic dysfunction and mortality in septic patients: a systematic review and meta-analysis

et al. 2015

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Diastolic dysfunction and mortality in septic patients: a systematic review and meta-analysis

et al. 2015

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“…When SIRS is associated with an infection, it is defined as sepsis [1-3]. Epidemiological studies worldwide [4-6] and in Brazil [7,8] indicate that sepsis is a prevalent condition with a high mortality rate that is associated with the emergence of multidrug-resistant pathogens [9,10] while also generating high social and financial costs [11]. Thiamine (vitamin B1) is a water soluble vitamin that does not accumulate in the body; therefore, it has to be ingested daily [12].…”

Section: Introductionmentioning

confidence: 99%

The effect of thiamine deficiency on inflammation, oxidative stress and cellular migration in an experimental model of sepsis

et al. 2014

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BackgroundSepsis is a prevalent condition in critically ill patients and may be associated with thiamine deficiency (TD). The aim of this study was to evaluate the effect of TD on inflammation, oxidative stress and cellular recruitment in a sepsis model.MethodsThe experimental sepsis model, cecal ligation and puncture (CLP), was utilized on mice in comparison with a sham procedure. The following four groups were compared against each other: SHAM with AIN93G complete chow, SHAM with thiamine deficient (TD) chow, CLP with AIN93G complete chow, and CLP with TD chow. Thiamine pyrophosphate (TPP) blood concentrations were determined, and blood and peritoneal fluid were evaluated for differences in TNF-alpha, IL-1, IL-6, KC and MCP-1/CCL2 levels. In addition, the levels of 4-HNE adducts in liver proteins were evaluated by Western Blot.ResultsThe mean TPP blood concentration from the mice fed with the complete chow was 303.3 ± 42.6 nmol/L, and TD occurred within 10 days. TNF-α and MCP-1 concentrations in the peritoneal fluid were significantly greater in the CLP with TD chow group when compared with the other groups. The blood IL-1β level, however, was lower in the CLP with TD chow group. Liver 4-HNE levels were highest in the TD chow groups. Blood mononuclear cell numbers, as well as peritoneal total leukocyte, mononuclear cell and neutrophil numbers were greater in the CLP with TD chow group. Peritoneal bacterial colony forming units (CFU) were significantly lower in the CLP with TD chow group.ConclusionTD was associated with greater bacterial clearance, oxidative stress and inflammatory response changes.

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“…It is, however, the case that preexisting or concurrent conditions like the presence of ARDS can lead to false-positive ultrasonography studies. 2 As this was not the objective of our study, we have not discussed this, but as Drs Peris and Barbani point out, it warrants further exploration. Drs Peris and Barbani comment on the limited number of radiographs performed in the semirecumbent position.…”

Section: Responsementioning

confidence: 88%

Ultrasonography for the Detection of Pneumothorax

Peris

Barbani

2012

Chest

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Year in review in Intensive Care Medicine 2011. II. Cardiovascular, infections, pneumonia and sepsis, critical care organization and outcome, education, ultrasonography, metabolism and coagulation

Cited by 39 publications

References 74 publications

Diastolic dysfunction and mortality in septic patients: a systematic review and meta-analysis

Diastolic dysfunction and mortality in septic patients: a systematic review and meta-analysis

The effect of thiamine deficiency on inflammation, oxidative stress and cellular migration in an experimental model of sepsis

Ultrasonography for the Detection of Pneumothorax

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