Year in review 2013: Lung cancer, respiratory infections, tuberculosis, cystic fibrosis, pleural diseases, bronchoscopic intervention and imaging

Leung, Chi Chiu; Porcel, José M.; Takahashi, Kazuhisa; Restrepo, Marcos I.; Lee, Pyng; Wainwright, Claire

doi:10.1111/resp.12250

Cited by 5 publications

(5 citation statements)

References 101 publications

(157 reference statements)

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“…Lung cancer is the most common cause of cancer related deaths and its main primary types are small lung cancer (10~15%) and non-small lung cancer (85~90%) worldwide [ 1 , 2 ]. In general, the treatment for lung cancer is surgery, chemotherapy, radiotherapy, immunotherapy and targeted therapy mainly for EGFR, VEGF, ALK and NF-κB [ 3 , 4 ].…”

Section: Introductionmentioning

confidence: 99%

Inhibition of STAT3/VEGF/CDK2 axis signaling is critically involved in the antiangiogenic and apoptotic effects of arsenic herbal mixture PROS in non-small lung cancer cells

Lee

Bae³

et al. 2017

Oncotarget

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Section: Introductionmentioning

confidence: 99%

Inhibition of STAT3/VEGF/CDK2 axis signaling is critically involved in the antiangiogenic and apoptotic effects of arsenic herbal mixture PROS in non-small lung cancer cells

Lee

Bae³

et al. 2017

Oncotarget

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“…It is known that Cisplatin, which is a widely used platinum group chemotherapeutic agent, has serious side effects, although its use alone or in combination with different drugs gives successful results in many types of cancer. [1][2][3][4][5] The presence of this platinum resistance in the cells has led researchers to the synthesis of new metal compounds. [6,7] There are transition metal complexes used as antitumor agents.…”

Section: Introductionmentioning

confidence: 99%

The Mechanism for Anticancer and Apoptosis‐Inducing Properties of Cu(II) Complex with Quercetin and 1,10‐Phenanthroline

et al. 2022

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This article covers the anticancer activities and mechanisms of action of Cu(II) complexes of flavonoid‐derived quercetin and 1,10‐phenanthroline ligands. The antiproliferative activity of the complex and its ligands was evaluated by MTT, ATP, and SRB viability assays in human lung cancer cells (A549, H1299). Findings for apoptosis were determined by fluorescent staining, flow cytometry analysis, and the M30 antigen method. In addition, the mechanism of action of the complex was investigated by Annexin V staining, caspase 3/7 activity, ROS formation, and cell cycle analysis. The involvement of caspases, thus, apoptosis was confirmed by rescuing cell death by using a pan‐caspase inhibitor (Z‐VAD‐FMK). Again, increased ROS levels in the cell showed that death may occur by apoptosis. For this reason, the accuracy of ROS‐induced apoptosis in cells has been proven as a result of the application of N‐acetylcysteine (NAC), which is a ROS inhibitor. The efficacy of the complex was compared with Cisplatin and ligands. The results showed that the Cu(II) flavonoid complex is cytotoxic on lung cancer cells and may have the potential to act as an effective metal‐based anticancer drug with a lower IC50 over Cisplatin.

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“…Lung cancer is one of the most common malignancies, and remains the leading cause of cancer-related deaths (Leung et al, 2014;Zhao et al, 2017a). When compared to other types of cancer, lung cancer rates are rapidly increasing owing to tobacco use, exposure to second-hand smoke, air pollution, and other possible causes (Bai et al, 2017;Zhao et al, 2017b).…”

Section: Introductionmentioning

confidence: 99%

Knockdown of TIGAR Induces Apoptosis and Autophagy with Modulates NF-κB and HO-1 Expression in A549 Lung Cancer Cells

Ağca

Shareef

2019

Iğdır Üniversitesi Fen Bilimleri Enstitüsü Dergisi

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ÖZET: TP53 kaynaklı glikoliz ve apoptozis düzenleyici (TIGAR) protein, glikoz metabolizması sırasında Fru-2, 6-P2 seviyelerini glukoz metabolizması sırasında kontrol eder ve nikotinamid adenin dinükleotit fosfat (NADPH) düzeyini devam ettirerek hücre içi anahtar bir antioksidan olan glutatyonun (GSH) geri dönüştürmesine yardımcı olur. Bu çalışma, A549 hücre hattında TIGAR'ın susturulmasının altında yatan, reaktif oksijen türleri (ROS) aracılı apoptotik ve otofajik mekanizmaları araştırmak için tasarlanmıştır. siRNA-TIGAR'ın A549 akciğer kanseri hücreleri üzerindeki etkisini saptamak için hücre canlılığı, koloni oluşumu, ROS ve NADPH analizlerini gerçekleştirdik. Ek olarak, protein ve mRNA ekspresyon seviyeleri sırası ile Western blot ve Real-time PCR yöntemleri ile belirlendi. TIGAR'ın A549 hücre hattında susturulmasının ardından, çeşitli parametreler analiz edildi ve TIGAR'ın down regülasyonunun hücre canlılığını inhibe ettiği ve koloni oluşumunu azalttığı gösterildi. TIGAR'ın susturulmasının apoptozis ve otofajiyi tetiklediğini ve bunu Nükleer faktör-kappa B (NF-κB) ve Hem oksijenaz-1 (HO-1)'in indüksiyonun izlediği belirledik. Dahası, artmış ROS düzeyi ve azalmış NADPH seviyeleri gözlemlendik. Bu çalışma, akciğer kanseri hücrelerinde, NF-κB ve HO-1 ekspresyonları ile apoptozis ve otofajiyi arttırmak için TIGAR susturulmasının kullanılmasını desteklemekte ve akciğer kanserinin tedavisi için potansiyel bir hedef olarak TIGAR önermektedir.

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Year in review 2013: Lung cancer, respiratory infections, tuberculosis, cystic fibrosis, pleural diseases, bronchoscopic intervention and imaging

Cited by 5 publications

References 101 publications

Inhibition of STAT3/VEGF/CDK2 axis signaling is critically involved in the antiangiogenic and apoptotic effects of arsenic herbal mixture PROS in non-small lung cancer cells

Inhibition of STAT3/VEGF/CDK2 axis signaling is critically involved in the antiangiogenic and apoptotic effects of arsenic herbal mixture PROS in non-small lung cancer cells

The Mechanism for Anticancer and Apoptosis‐Inducing Properties of Cu(II) Complex with Quercetin and 1,10‐Phenanthroline

Knockdown of TIGAR Induces Apoptosis and Autophagy with Modulates NF-κB and HO-1 Expression in A549 Lung Cancer Cells

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