Abstract:Condensins play a
key role in higher order chromosome organization.
In budding yeast Saccharomyces cerevisiae, a condensin complex consists of five subunits: two conserved structural
maintenance of chromosome subunits, Smc2 and Smc4, a kleisin Brn1,
and two HEAT repeat subunits, Ycg1, which possesses a DNA binding
activity, and Ycs4, which can transiently associate with Smc4 and
thereby disrupt its association with the Smc2 head. We characterized
here DNA binding activity of the non-SMC subunits using an agnos… Show more
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