YB-1 as an Oncoprotein: Functions, Regulation, Post-Translational Modifications, and Targeted Therapy

Yin, Qiyan; Zheng, Min; Luo, Qianmei; Jiang, Dewei; Zhang, Huifeng; Chen, Ceshi

doi:10.3390/cells11071217

Cited by 28 publications

(19 citation statements)

References 195 publications

(229 reference statements)

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“…This analysis revealed strong conservation of the MR proteins associated with the M + and M - states across all three PDLs (p ≤ 1.5.X10 -13 , by two-tailed GSEA test with 1000 permutations ) (Figure 1F-G) . Among the most differentially activated MRs, we found TFs associated with RAS signaling, such as YY1 and YBX1, while the most inactivated MRs included PTF1A and RBPJL, established acinar cell regulators that are typically inactivated upon RAS activation (Lin et al, 2020; Yin et al, 2022; Yuan et al, 2017).…”

Section: Resultsmentioning

confidence: 97%

Developmental and MAPK-responsive transcription factors drive distinct malignant subtypes and genetic dependencies in pancreatic cancer

Laise

Turunen

Garcia³

et al. 2020

Preprint

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Despite extensive efforts to characterize the transcriptional landscape of pancreatic ductal adenocarcinoma (PDA), reproducible assessment of subtypes with actionable dependencies remains challenging. Systematic, network-based analysis of regulatory protein activity stratified PDA tumours into novel functional subtypes that were highly conserved across multiple cohorts, including at the single cell level and in laser capture microdissected (LCM) samples. Identified subtypes were characterized by activation of master regulator proteins representing either gastrointestinal lineage markers or transcriptional effectors of morphogen pathways. Single cell analysis confirmed the existence of Lineage and Morphogenic states but also revealed a dominant population of more differentiated Oncogenic Precursor (OP) cells , present in all sampled patients, yet not apparent from bulk tumor analysis. Master regulators were validated by pooled, CRISPR/Cas9 screens, demonstrating both subtype-specific and universal dependencies. Conversely, ectopic expression of Lineage MRs, such as OVOL2, was sufficient to reprogram Morphogenic cells, thus providing a roadmap for the future targeting of patient-specific dependencies in PDA.

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Section: Resultsmentioning

confidence: 97%

Developmental and MAPK-responsive transcription factors drive distinct malignant subtypes and genetic dependencies in pancreatic cancer

Laise

Turunen

Garcia³

et al. 2020

Preprint

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“…Y-box binding protein 1 (YB1), known as a protein member of the cold shock domain (CSD) protein family, can promote the progression of multiple cancers and acts as a possible biomarker and therapeutic target [ 69 ]. In SCLC, LINC00173 directly interacts with the YB1 protein, further promoting the nuclear translocation and phosphorylation of YB1.…”

Section: Biological Roles Of Linc00173mentioning

confidence: 99%

Long Intergenic Non-Protein Coding RNA 173 in Human Cancers

Mao

Liao

Tang

2022

Cancers

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Long non-coding RNAs belong to non-coding RNAs (ncRNAs) with a length of more than 200 nucleotides and limited protein-coding ability. Growing research has clarified that dysregulated lncRNAs are correlated with the development of various complex diseases, including cancer. LINC00173 has drawn researchers’ attention as one of the recently discovered lncRNAs. Aberrant expression of LINC00173 affects the initiation and progression of human cancers. In the present review, we summarize the recent considerable research on LINC00173 in 11 human cancers. Through the summary of the abnormal expression of LINC00173 and its potential molecular regulation mechanism in cancers, this article indicates that LINC00173 may serve as a potential diagnostic biomarker and a target for drug therapy, thus providing novel clues for future related research.

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“…Because YB-1 is remarkably multifunctional and orchestrates many cellular functions that basically determine the fate of a cell, its activity needs to be tightly controlled. The functional fine tuning of YB-1 is achieved by several post-translational modifications including phosphorylation, methylation, acetylation and ubiquitylation ( Yin et al, 2022 ).…”

Section: Yb-1 At a Glancementioning

confidence: 99%

“…Especially the latter is associated with a poor prognosis and a highly aggressive course of disease ( Kamura et al, 1999 ). The oncogenic characteristics of YB-1 have already been comprehensively reviewed ( Lasham et al, 2013 ; Johnson et al, 2019 ; Shah et al, 2021 ; Yin et al, 2022 ) and here will be summarized only in short.…”

Section: Yb-1 At a Glancementioning

confidence: 99%

“…Briefly, after the discovery of YB-1, it was found to be overexpressed in several tumors. Consequently, the research on YB-1 has focused mainly on its role as an oncoprotein and its use as prognostic marker and therapeutic target in cancer ( Yin et al, 2022 ). Moreover, several studies investigated the association between YB-1 and inflammation ( Rybalkina and Moiseeva, 2022 ).…”

Section: Introductionmentioning

confidence: 99%

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An old friend with a new face: YB-1 and its role in healthy pregnancy and pregnancy-associated complications

Fischer

Schumacher²,

Meyer³

et al. 2022

Front. Cell Dev. Biol.

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By promoting tissue invasion, cell growth and angiogenesis, the Y-box binding protein (YB-1) became famous as multifunctional oncoprotein. However, this designation is telling only part of the story. There is one particular time in life when actual tumorigenic-like processes become undoubtedly welcome, namely pregnancy. It seems therefore reasonable that YB-1 plays also a crucial role in reproduction, and yet this biological aspect of the cold-shock protein has been overlooked for many years. To overcome this limitation, we would like to propose a new perspective on YB-1 and emphasize its pivotal functions in healthy pregnancy and pregnancy-related complications. Moreover, we will discuss findings obtained from cancer research in the light of reproductive events to elucidate the importance of YB-1 at the feto-maternal interface.

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YB-1 as an Oncoprotein: Functions, Regulation, Post-Translational Modifications, and Targeted Therapy

Cited by 28 publications

References 195 publications

Developmental and MAPK-responsive transcription factors drive distinct malignant subtypes and genetic dependencies in pancreatic cancer

Developmental and MAPK-responsive transcription factors drive distinct malignant subtypes and genetic dependencies in pancreatic cancer

Long Intergenic Non-Protein Coding RNA 173 in Human Cancers

An old friend with a new face: YB-1 and its role in healthy pregnancy and pregnancy-associated complications

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