Yarrowia lipolytica, health benefits for animals

Yarrowia lipolytica as an Alternative and Valuable Source of Nutritional and Bioactive Compounds for Humans

“…e.g., Atlantic salmon [ 33 , 34 ], Nile tilapia [ 35 ], and Pacific red snapper [ 36 ]; birds, e.g., turkeys [ 37 , 38 , 39 ], piglets [ 40 , 41 , 42 ]; and ruminants, e.g., calves [ 34 ]. Dried and heat-killed yeast biomass work effectively as immunostimulants and animal growth promoters [ 35 , 37 , 39 , 43 ].…”

Study of the persistence and dynamics of recombinant mCherry‐producing Yarrowia lipolytica strains in the mouse intestine using fluorescence imaging

“…Beneficial health effects of Y. lipolytica on animals include productive performance, immune enhancement, redox balance and disease resistance. This yeast also improved fatty acid composition in muscle or fillet, haematobiochemical parameters, maturation and microbial populations of the gastrointestinal tract (Guardiola et al, 2021 ).…”

“…However, despite the huge attention that is being given to Y. lipolytica for the industrial manufacturing of various heterologous proteins (Madzak, 2021b ; Madzak & Beckerich, 2013 ) and for probiotic effects, its potential for oral delivery of recombinant therapeutic proteins (particularly for their effect in the gastrointestinal tract, GIT) has seldom been evaluated in mammals and rarely in other vertebrates. Inspired by its use as feed and/or dietary supplement in pisci/aquaculture, several research teams have used Y. lipolytica as a vector for heterologous immunogenic proteins or antibacterial peptides to protect fish or shrimps against infections (Guardiola et al, 2021 ). In contrast, such studies are rarer in mammals but one unique study showed that freeze‐dried viral capsid proteins produced by Y. lipolytica can be used as an oral vaccine to protect mice against viral nervous necrosis (Luu et al, 2017 ).…”

“…Industrial good manufacturing practices production platforms based on engineered Y. lipolytica have been developed since the 2000s and include new white biotechnological applications, for example as a functional feed additive for animals or a source of human milk oligosaccharide for infant milk formulations (Guardiola et al, 2021; Madzak, 2021a). Y. lipolytica biomass from a proprietary wild‐type strain is commercialized as fodder yeast for farm and pet animals by Skotan SA (Chorzów, Poland), a company that also develops prebiotic/probiotic applications for this yeast (Jach & Malm, 2022; Madzak, 2021a; Zinjarde, 2014).…”

“…Y. lipolytica biomass from a proprietary wild‐type strain is commercialized as fodder yeast for farm and pet animals by Skotan SA (Chorzów, Poland), a company that also develops prebiotic/probiotic applications for this yeast (Jach & Malm, 2022; Madzak, 2021a; Zinjarde, 2014). Indeed, several in vivo studies reported probiotic properties of this yeast in mammals, birds, fish, crustaceans and molluscs (Guardiola et al, 2021). Beneficial health effects of Y. lipolytica on animals include productive performance, immune enhancement, redox balance and disease resistance.…”